Feeding behavior and sensorimotor functioning in rats with unilateral medial forebrain bundle damage

Uguru-Okorie, D. C.

doi:10.3758/bf03327205

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Consequently, the detected relationship between Y1 receptor and dynorphin with food grinding also indicates that food grinding is a feeding-related behavior. Unilateral medial forebrain bundle damage, which causes an obvious reduction in the levels of dopamine and norepinephrine in the ipsilateral mesolimbic area or striatum, increases food spillage in male Wistar albino rats, indicating that stereotypical food grinding behavior may be associated with dopamine pathways in the striatum [23,49]. These results indicate that food grinding behavior is genetically regulated in addition to its inheritance.…”

Section: Gene Expressionmentioning

confidence: 84%

Food Grinding Behavior: A Review of Causality and Influential Factors

Tang,

Ge,

Wei

et al. 2024

Animals

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Food waste is a common issue arising from grinding of food by experimental animals, leading to excessive food scraps falling into cages. In the wild, animals grind food by gnawing vegetation and seeds, potentially damaging the ecological environment. However, limited ecology studies have focused on food grinding behavior since the last century, with even fewer on rodent food grinding, particularly recently. Although food grinding’s function is partially understood, its biological purposes remain under-investigated and driving factors unclear. This review aims to explain potential causes of animal food grinding, identify influencing factors, and discuss contexts and limitations. Specifically, we emphasize recent progress on gut microbiota significance for food grinding. Moreover, we show abnormal food grinding is determined by degree of excess normal behavior, emphasizing food grinding is not meaningless. Findings from this review promote comprehensive research on the myriad factors, multifaceted roles, and intricate evolution underlying food grinding behavior, benefiting laboratory animal husbandry and ecological environment protection, and identifying potential physiological benefits yet undiscovered.

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Section: Gene Expressionmentioning

confidence: 84%

Food Grinding Behavior: A Review of Causality and Influential Factors

Tang,

Ge,

Wei

et al. 2024

Animals

View full text Add to dashboard Cite

show abstract

“…Consequently, the detected relationship between Y1 receptor and dynorphin with food grinding also indicates that food grinding is a feeding-related behavior. Unilateral medial forebrain bundle damage, which causes an obvious reduction in the levels of dopamine and norepinephrine in the ipsilateral mesolimbic area or striatum, increases food spillage in male Wistar albino rats, indicating that stereotypical food grinding behavior may be associated with dopamine pathways in the striatum [23,42]. These results indicate that food grinding behavior is genetically regulated in addition to its inheritance.…”

Section: Genes Expressionmentioning

confidence: 84%

Food Grinding Behavior: A Review of Causality and Influential Factors

Tang,

Ge,

Wei

et al. 2024

Preprint

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Food waste is a common issue arising from grinding of food by experimental animals, leading to excessive food scraps falling into cages. In the wild, animals grind food by gnawing vegetation and seeds, potentially damaging the ecological environment. However, limited ecology studies have focused on food grinding behavior since the last century, with even fewer on rodent food grinding, particularly recently. Although food grinding function is partially understood, biological purposes remain under-investigated and driving factors unclear. This review aims to explain potential causes of animal food grinding, identify influencing factors, and discuss contexts and limitations. Specifically, we emphasize recent progress on gut microbiota significance for food grinding. Moreover, we show abnormal food grinding is determined by degree of excess normal behavior, emphasizing food grinding is not meaningless. Findings from this review promote comprehensive research on the myriad factors, multifaceted roles, and intricate evolution underlying food grinding behavior, benefiting laboratory animal husbandry and ecological environment protection, and identifying potential physiological benefits yet undiscovered.

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“…In fact, it has been reported that when 6‐OHDA was injected into different brain regions, different weight changes were obtained, and even the weight changes in the same injection site were also different in different studies. For SN, weight loss has been observed (Drui et al, 2014); however, unchanged body weight was also reported (Zheng et al, 2011, 2014); for MFB, most studies found weight loss (Blunt et al, 1991; Uguru‐Okorie, 1984; Wang et al, 2017), whereas Meng et al (Meng et al, 2015) study found no change of body weight; for the striatum, it has reported that degeneration of the striatum also failed to produce a significant change in the body weight of rats (Guimaraes et al, 2013). In addition, we have also observed the retroperitoneal white adipose tissue (rWAT), expressed relative to body weight, was lower in the 6‐OHDA rats as well as the increased lipolysis and decreased synthesis (Lian, Zhou, Zhang, Song, & Wang, 2020), which is consistent with the previous study (Meng et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported in the literature that the 6‐hydroxydopamine (6‐OHDA)‐induced PD model rats also display weight loss after surgery (Baez, Ahlskog, & Randall, 1977; Blunt, Jenner, & Marsden, 1991; Uguru‐Okorie, 1981, 1984). Currently, damaging dopaminergic neurons in the bilateral substantia nigra (SN) of rats through the injection of 6‐OHDA is regarded as a common method of establishing a PD model (Ariza, Sisdeli, Crestani, Fazan, & Martins‐Pinge, 2015; Vecchia et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Increased energy expenditure and activated β3‐AR‐cAMP‐PKA signaling pathway in the interscapular brown adipose tissue of 6‐OHDA‐induced Parkinson's disease model rats

Lian

Zhou

Zhang

et al. 2020

The Anatomical Record

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To explore the possible mechanism of weight loss in Parkinson's disease (PD). Bilateral injections of 6‐hydroxydopamine (6‐OHDA) into substantia nigra (SN) were performed to induce the PD model rats. The rotarod test, food intake, body weight, and interscapular brown adipose tissue (IBAT) weight were recorded 6 weeks postoperation. HE staining was performed to observe the morphology of multilocular adipose cells in IBAT. Immunohistochemistry and western blot were used to determine the protein levels of tyrosine hydroxylase (TH) in the SN, and the levels of uncoupling protein 1 (UCP1), peroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α), phosphorylated‐hormone sensitive lipase (p‐HSL), HSL, TH, β3‐adrenergic receptor (β3‐AR), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA) in IBAT. After treatment with 6‐OHDA for 6 weeks, 6‐OHDA rats exhibited decreased TH expression in SN accompanied with shortened staying time on the rotating rod. This motor impairment paralleled with no significant alteration in body mass, IBAT weight, and food intake until the end of the experimental protocol. However, the decreasing diameter of the single fat vesicle in IBAT was observed in the 6‐OHDA group. Meanwhile, compared with the control group, the protein expression of UCP1, PGC‐1α, p‐HSL, TH, β3‐AR, cAMP, and PKA in IBAT were increased significantly in the 6‐OHDA group, whereas no obvious change in the expression of HSL. The present study suggested an increased energy expenditure and activation of the β3‐AR‐cAMP‐PKA signaling pathway in the IBAT after the destruction of the dopamine system in the SN of the rat.

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Feeding behavior and sensorimotor functioning in rats with unilateral medial forebrain bundle damage

Cited by 6 publications

References 16 publications

Food Grinding Behavior: A Review of Causality and Influential Factors

Food Grinding Behavior: A Review of Causality and Influential Factors

Food Grinding Behavior: A Review of Causality and Influential Factors

Increased energy expenditure and activated β3‐AR‐cAMP‐PKA signaling pathway in the interscapular brown adipose tissue of 6‐OHDA‐induced Parkinson's disease model rats

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