Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels

Medeiros, Denis M.; Hampton, Meghan; Kurtzer, Kelly; Parelman, Mardi; Al‐Tamimi, Enas; Drouillard, James S.

doi:10.1016/j.nutres.2007.04.003

Cited by 16 publications

(8 citation statements)

References 12 publications

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“…Earlier studies have shown that feeding a diet containing ALA can increase the level of this FA as well as the level of long chain metabolites, to varying degrees [46][47][48][49][50][51]. Rats fed SLs and blends with n-3 PUFA increased the amount of n-3 PUFA in the liver and heart tissue which is in agreement with the findings of Medeiros et al [52]. The brain is a unique organ characterized by the presence of a high concentration of DHA, which influences its structure and functional properties [53].…”

Section: Discussionsupporting

confidence: 90%

Effects of Rice Bran Oil Enriched with n‐3 PUFA on Liver and Serum Lipids in Rats

Chopra

Sambaiah

2008

Lipids

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Lipase-catalyzed interesterification was used to prepare different structured lipids (SL) from rice bran oil (RBO) by replacing some of the fatty acids with alpha-linolenic acid (ALA) from linseed oil (LSO) and n-3 long chain polyunsaturated fatty acids (PUFA) from cod liver oil (CLO). In one SL, the ALA content was 20% whereas in another the long chain n-3 PUFA content was 10%. Most of the n-3 PUFA were incorporated into the sn-1 and sn-3 positions of triacylglycerol. The influence of SL with RBO rich in ALA and EPA + DHA was studied on various lipid parameters in experimental animals. Rats fed RBO showed a decrease in total serum cholesterol by 10% when compared to groundnut oil (GNO). Similarly structured lipids with CLO and LSO significantly decreased total serum cholesterol by 19 and 22% respectively compared to rice bran oil. The serum TAGs level of rats fed SLs and blended oils were also significantly decreased by 14 and 17% respectively compared to RBO. Feeding of an n-3 PUFA rich diet resulted in the accumulation of long chain n-3 PUFA in various tissues and a reduction in the long chain n-6 PUFA. These studies indicate that the incorporation of ALA and EPA + DHA into RBO can offer health benefits.

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Section: Discussionsupporting

confidence: 90%

Effects of Rice Bran Oil Enriched with n‐3 PUFA on Liver and Serum Lipids in Rats

Chopra

Sambaiah

2008

Lipids

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“…Our findings also suggest a statistically significant increase in the ALA content of the rat muscle tissue, liver, and heart as a result of feeding on the omega-3 enriched chevon diet. Other longer chain omega-3 FAs especially DHA also increased in the omega-3 enriched chevron group compared to CON group which supported the observation by Medeiros et al [ 22 ] who fed rats with high omega-3 beef. The rats fed on the omega-3 enriched chevon diet not only ate more ALA than the CON rats but also consumed more EPA, docosapentanoic acid, and DHA.…”

Section: Discussionsupporting

confidence: 88%

Omega-3 Fatty Acid Enriched Chevon (Goat Meat) Lowers Plasma Cholesterol Levels and Alters Gene Expressions in Rats

Ebrahimi

Rajion

Goh

et al. 2014

BioMed Research International

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In this study, control chevon (goat meat) and omega-3 fatty acid enriched chevon were obtained from goats fed a 50% oil palm frond diet and commercial goat concentrate for 100 days, respectively. Goats fed the 50% oil palm frond diet contained high amounts of α-linolenic acid (ALA) in their meat compared to goats fed the control diet. The chevon was then used to prepare two types of pellets (control or enriched chevon) that were then fed to twenty-male-four-month-old Sprague-Dawley rats (n = 10 in each group) for 12 weeks to evaluate their effects on plasma cholesterol levels, tissue fatty acids, and gene expression. There was a significant increase in ALA and docosahexaenoic acid (DHA) in the muscle tissues and liver of the rats fed the enriched chevon compared with the control group. Plasma cholesterol also decreased (P < 0.05) in rats fed the enriched chevon compared to the control group. The rat pellets containing enriched chevon significantly upregulated the key transcription factor PPAR-γ and downregulated SREBP-1c expression relative to the control group. The results showed that the omega-3 fatty acid enriched chevon increased the omega-3 fatty acids in the rat tissues and altered PPAR-γ and SREBP-1c genes expression.

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“…Many laboratories are currently using GC to analyse fatty acid composition in various matrices such as cell membranes and cultures [4], microorganisms [5], plasma [6], tissues [7], etc. These studies have greatly expanded our knowledge in areas such as cellular function, bacterial taxonomy, aquaculture, human and animal nutrition, fatty acid metabolism, etc.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices

Araujo¹,

Nguyen²,

Frøyland³

et al. 2008

Journal of Chromatography A

103

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A simplified method for quantitative analysis of fatty acids in various matrices by gas chromatography is proposed as an alternative to the conventional method and the variables of the protocol examined to optimize the processing conditions. The modified method involves direct methylation of fatty acids in homogenized samples with boron trihalide (BF 3 or BCl 3 in methanol) followed by extraction with hexane. The addition of hexane to the reaction mixture after the methylation process can enhance the efficiency of fatty acid methylation and is critical for those samples that contain high levels of triglycerides. A mechanism underlying this effect is proposed.

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Feeding enriched omega-3 fatty acid beef to rats increases omega-3 fatty acid content of heart and liver membranes and decreases serum vascular cell adhesion molecule-1 and cholesterol levels

Cited by 16 publications

References 12 publications

Effects of Rice Bran Oil Enriched with n‐3 PUFA on Liver and Serum Lipids in Rats

Effects of Rice Bran Oil Enriched with n‐3 PUFA on Liver and Serum Lipids in Rats

Omega-3 Fatty Acid Enriched Chevon (Goat Meat) Lowers Plasma Cholesterol Levels and Alters Gene Expressions in Rats

Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices

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