Feeding, fecundity and lifespan in female
            <i>Drosophila melanogaster</i>

Barnes, Andrew I; Wigby, Stuart; Boone, James M.; Partridge, Linda; Chapman, Tracey

doi:10.1098/rspb.2008.0139

Cited by 135 publications

(142 citation statements)

References 52 publications

(149 reference statements)

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“…This appears to be an indirect effect of SP signalling since the elevated feeding depends on the ability to produce eggs (Barnes et al 2008). Our study suggests that SP changes feeding-related behaviours not only by elevating appetite, but also by stimulating foraging behaviour by modulating day-time sleep -wake activity.…”

Section: Discussionmentioning

confidence: 77%

Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female

et al. 2009

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Quiescence, or a sleep-like state, is a common and important feature of the daily lives of animals from both invertebrate and vertebrate taxa, suggesting that sleep appeared early in animal evolution. Recently, Drosophila melanogaster has been shown to be a relevant and powerful model for the genetic analysis of sleep behaviour. The sleep architecture of D. melanogaster is sexually dimorphic, with females sleeping much less than males during day-time, presumably because reproductive success requires greater foraging activity by the female as well as the search for egg-laying sites. However, this loss of sleep and increase in locomotor activity will heighten the risk for the female from environmental and predator hazards. In this study, we show that virgin females can minimize this risk by behaving like males, with an extended afternoon 'siesta'. Copulation results in the female losing 70 per cent of day-time sleep and becoming more active. This behaviour lasts for at least 8 days after copulation and is abolished if the mating males lack sex peptide (SP), normally present in the seminal fluid. Our results suggest that SP is the molecular switch that promotes wakefulness in the post-mated female, a change of behaviour compatible with increased foraging and egg-laying activity. The stress resulting from SP-dependent sleep deprivation might be an important contribution to the toxic side-effects of male accessory gland products that are known to reduce lifespan in post-mated females.

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Section: Discussionmentioning

confidence: 77%

Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female

et al. 2009

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“…SP induces multiple physiological and behavioral responses in females including increased egg laying and reduced receptivity to males. 72,73 Some of these responses are age-dependent; while receptivity decreases in females of all ages, only young previously-virgin females increase fecundity. 27 The ability of females to detect or respond to SP signals has been hypothesized to diminish with age.…”

Section: Fecunditymentioning

confidence: 99%

The song of the old mother: Reproductive senescence in female drosophila

Miller

Obrik-Uloho

Phan

et al. 2014

Fly

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Among animals with multiple reproductive episodes, changes in adult condition over time can have profound effects on lifetime reproductive fitness and offspring performance. The changes in condition associated with senescence can be particularly acute for females who support reproductive processes from oogenesis through fertilization. The pomace fly Drosophila melanogaster is a well-established model system for exploring the physiology of reproduction and senescence. In this review, we describe how increasing maternal age in Drosophila affects reproductive fitness and offspring performance as well as the genetic foundation of these effects. Describing the processes underlying female reproductive senescence helps us understand diverse phenomena including population demographics, conditiondependent selection, sexual conflict, and transgenerational effects of maternal condition on offspring fitness. Understanding the genetic basis of reproductive senescence clarifies the nature of life-history trade-offs as well as potential ways to augment and/or limit female fertility in a variety of organisms.

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“…Feeding rate and egg production are interrelated biological processes in Drosophila. Feeding rate is controlled by a molecular pathway which regulates egg production through an ejaculate "sex peptide" [40]. Previous studies have shown that increases in female feeding correlated with higher reproductive rates reflected by higher egg production [41].…”

Section: Discussionmentioning

confidence: 99%

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

et al. 2017

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Diverse physiological pathways have been shown to regulate longevity, stress resistance, fecundity and feeding rates, and metabolism in Drosophila. Here we tesed physiological traits in flies with Rheb and MycRheb overexpressed in gut progenitor cells, known as enteroblasts (EBs). We found that activation of TOR signaling by overexpression of Rheb in EBs decreases survival and stress resistance. Additionall, we showed that Myc co-expression in EBs reduces fly fecundity and feeding rate. Rheb overexpression enhanced the level of whole body glucose. Higher relative expression of the metabolic genes dilps, akh, tobi and pepck was, however, observed. The role of TOR/Myc in the regulation of genes involved in lipid metabolism and protein synthesis was established. We showed a significant role of TOR/ Myc in EBs in the regulation of the JAK/STAT, EGFR and insulin signaling pathways in Drosophila gut. These results highlight the importance of the balance between all different types of cells and confirm previous studies demonstrating that promotion of homeostasis in the intestine of Drosophila may function as a mechanism for the extension of organismal lifespan. Overall, the results demonstrate a role of TOR signaling and its downstream target Myc in EB cells in the regulation of Drosophila physiological processes.

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Feeding, fecundity and lifespan in female Drosophila melanogaster

Cited by 135 publications

References 52 publications

Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female

Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female

The song of the old mother: Reproductive senescence in female drosophila

Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of Drosophila gut

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