Feeding Grass Hay Before Concentrate Mitigates the Effect of Grain-Based Concentrates on Postprandial Plasma Interleukin-1β

Suagee-Bedore, J.K.; Linden, Daniel R.; Bennett-Wimbush, K.; Splan, Rebecca K.

doi:10.1016/j.jevs.2019.102899

Cited by 4 publications

(3 citation statements)

References 40 publications

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“…To our knowledge, there is no data available specifically associating defective hindgut barrier function with laminitis in ruminants. However, in horses, grain supplementation and increased intake of rapidly fermentable carbohydrates result in systemic inflammation and a higher incidence of laminitis [ 55 , 56 ]. Assuming that horses, being posterior fermenters, could serve as a viable model for ruminants, this data supports that hindgut acidosis could play a role in the development of laminitis in cattle.…”

Section: Intestinal Health and Inflammationmentioning

confidence: 99%

Targeting the Hindgut to Improve Health and Performance in Cattle

Fernández¹,

Daniel²,

Seymour³

et al. 2020

Animals

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An adequate gastrointestinal barrier function is essential to preserve animal health and well-being. Suboptimal gut health results in the translocation of contents from the gastrointestinal lumen across the epithelium, inducing local and systemic inflammatory responses. Inflammation is characterized by high energetic and nutrient requirements, which diverts resources away from production. Further, barrier function defects and inflammation have been both associated with several metabolic diseases in dairy cattle and liver abscesses in feedlots. The gastrointestinal tract is sensitive to several factors intrinsic to the productive cycles of dairy and beef cattle. Among them, high grain diets, commonly fed to support lactation and growth, are potentially detrimental for rumen health due to their increased fermentability, representing the main risk factor for the development of acidosis. Furthermore, the increase in dietary starch associated with such rations frequently results in an increase in the bypass fraction reaching distal sections of the intestine. The effects of high grain diets in the hindgut are comparable to those in the rumen and, thus, hindgut acidosis likely plays a role in grain overload syndrome. However, the relative contribution of the hindgut to this syndrome remains unknown. Nutritional strategies designed to support hindgut health might represent an opportunity to sustain health and performance in bovines.

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Section: Intestinal Health and Inflammationmentioning

confidence: 99%

Targeting the Hindgut to Improve Health and Performance in Cattle

Fernández¹,

Daniel²,

Seymour³

et al. 2020

Animals

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“…Therefore, sugar and starch are likely to contribute to the inflammatory state of horses with CPL, which are already prone to inflammation at the level of the distal limbs. High-starch diets elevate plasma concentrations of interleukin-1β (IL-1β) as soon as one hour post-eating [ 68 ]. This increase in IL-1β is possibly due to changes in the intestinal pH that result from the rapid bacterial fermentation of starches and sugars in the digestive tract [ 68 ].…”

Section: Factors Associated With Occurrence and Severity Of Cplmentioning

confidence: 99%

“…High-starch diets elevate plasma concentrations of interleukin-1β (IL-1β) as soon as one hour post-eating [ 68 ]. This increase in IL-1β is possibly due to changes in the intestinal pH that result from the rapid bacterial fermentation of starches and sugars in the digestive tract [ 68 ]. Moreover, a higher level of tumor necrosis factor-α is observed in horses that are fed a diet high in sugar and starch, indicating an increase in some level of systemic inflammation [ 69 ].…”

Section: Factors Associated With Occurrence and Severity Of Cplmentioning

confidence: 99%

Chronic Progressive Lymphedema in Belgian Draft Horses: Understanding and Managing a Challenging Disease

Bryś

Claerebout

Chiers

2023

Veterinary Sciences

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Chronic progressive lymphedema (CPL) in draft horses is characterized by increased dermal thickness and fibrosis, with the development of skinfolds and nodules, hyperkeratosis, and ulcerations on the distal limbs of affected horses. Secondary bacterial, fungal, or parasitic infections frequently complicate and aggravate the lesions, as well as the progression of this disease. CPL has a particularly high prevalence of up to 85.86% in the Belgian draft horse breed. Due to the disease’s progressive and incurable nature, affected horses are often euthanized prematurely. The treatment options are solely symptomatic, aimed at improving the horse’s quality of life. Despite the severity of this condition, many uncertainties about its etiology and pathogenesis still remain to date. The established scientific research on CPL is rather limited, although there is an urgent need for strategies to tackle this disease. This review summarizes the available knowledge, serving as a guideline for practitioners, and provides perspectives for future research programs.

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