Feeding methods for the preterm infant

Berseth, Carol Lynn

doi:10.1053/siny.2001.0062

Cited by 16 publications

(19 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…feedings, using feeding guidelines, have been implemented and these too have been shown to improve weight gain. [13][14][15][16][17][18] We recognize that our new weight grid does not display 'ideal' weight changes, but it displays actual changes, using a large cohort of heterogeneous low birth weight (LBW) NICU patients in four different hospitals. The lack of initial weight loss we observed among the smallest neonates was not seen in the previous growth grids.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] On the basis of these, we hypothesized that NICU patients cared for currently have more rapid weight gain than are displayed on the commonly used postnatal grids. [2][3][4][5] To test this we collected, from electronic records, all daily weights of all patients with birth weights 400-2600 g, born during a 30-month period, January 1, 2003-June 30, 2005, cared for in any the NICU's of the Intermountain Health Care (IHC) System.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

et al. 2005

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

et al. 2005

View full text Add to dashboard Cite

“…1,2 As recently outlined by Jadcherla and Kliegman, 2 no uniform definition of feeding intolerance in the NICU exists, but its various manifestations are well known and include distended loops of bowel, emesis, large prefeeding gastric residuals, diarrhea, or gross blood in the stools. Feeding intolerance can prolong the need for parenteral nutrition and add to the length of hospitalization.…”

Section: Introductionmentioning

confidence: 99%

“…Feeding intolerance can prolong the need for parenteral nutrition and add to the length of hospitalization. 1,2 Since the length of time parenteral nutrition is used in the NICU correlates with the likelihood of developing a nosocomial infection, improving feeding tolerance could diminish reliance on parenteral nutrition and thereby reduce nosocomial infections. 3 Many factors likely contribute to feeding intolerance among VLBW neonates.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] However, it is likely that in a future randomized trial, needed to test the efficacy of the solution in preventing feeding intolerance, it would be administered for periods exceeding 3 days. We conducted the present study for two reasons, (1) to test the feasibility of administering this solution to VLBW neonates for up to 14 days, and (2) to obtain data on enteral caloric intake of recipients on which to base a subsequent randomized trial. Thus, we administered the test solution to 10 neonates and compared their enteral caloric intake during their first 3 weeks of life with that of 10 patients who met the study criteria but were born in the period immediately prior to initiation of the study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enteral Administration of a Simulated Amniotic Fluid to Very Low Birth Weight Neonates

et al. 2005

View full text Add to dashboard Cite

DO OBJECTIVE:To reduce feeding intolerance among very low birth weight neonates. STUDY DESIGN:A total of 10 neonates with birth weights of 750 to 1250 g were given oralgastric boluses (2.5 ml/kg every 3 hours) of a solution patterned after amniotic fluid. When milk feedings were begun the milk was mixed with the test solution. The solution was given at a constant daily dose of 20 ml/ kg/day while the volumes of milk feedings were gradually increased. When milk feedings reached 80 ml/kg/day the test solution was discontinued. A comparison group consisted of neonates who met study criteria but were cared for during the period immediately preceding the study. The outcome was the number of calories taken enterally over the first 21 days of life. RESULTS:The test solution was begun an average of 27 hours after birth (range, 4 to 45). In the test group the first milk feedings were introduced 74 hours after birth (range, 18 to 144), which was similar to the time milk was introduced in the comparison subjects (79 hours; range, 18 to 168). After milk feedings were started, the test patients had a total of four NPO days (0.4 NPO days per patient) during their first 21 days, while the comparison group had 34 NPO days (3.4 NPO days per patient). During the first 14 days of life the test solution recipients had a median of 26.5 enteral cal/kg/day (range, 4.3 to 68.9), while the comparison neonates had 8.5 (range, 0.2 to 25; p<0.05). During the first 21 days of life the test solution recipients had a median of 56.9 enteral cal/kg/day (range, 11.5 to 89.4), while the comparison neonates had 19.2 (range, 0.9 to 52.8; p<0.05). CONCLUSION:In all, 10 VLBW infants tolerated the test solution for periods up to 14 days with no significant adverse effects. A randomized trial to determine whether this solution reduces feeding intolerance among VLBW neonates should be conducted.

show abstract

Leucine is a major regulator of muscle protein synthesis in neonates

2014

View full text Add to dashboard Cite

Approximately 10% of infants born in the United States are of low birth weight. Growth failure during the neonatal period is a common occurrence in low birth weight infants due to their inability to tolerate full feeds, concerns about advancing amino acid supply, and high nutrient requirements for growth. An improved understanding of the nutritional regulation of growth during this critical period of development is vital for the development of strategies to improve lean growth. Past studies with animal models have demonstrated that muscle protein synthesis is increased substantially following a meal and that this increase is due to the postprandial rise in amino acids as well as insulin, which independently stimulate protein synthesis in a mammalian target of rapamycin (mTOR)-dependent manner. Further studies have elucidated that leucine, in particular, as well as its metabolites, α-ketoisocaproic acid and β-hydroxy-β-methylbutyrate, have unique anabolic properties. Supplementation with leucine, provided either parenterally or enterally, has been shown to enhance muscle protein synthesis in neonatal pigs, making it an ideal candidate for stimulating growth of low birth weight infants.

show abstract

Feeding methods for the preterm infant

Cited by 16 publications

References 57 publications

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system

Enteral Administration of a Simulated Amniotic Fluid to Very Low Birth Weight Neonates

Leucine is a major regulator of muscle protein synthesis in neonates

Contact Info

Product

Resources

About