In completely randomized block design, seventy two weaner New Zealand White (NZW) rabbits, 4-5 weeks old and with an average body weight of 458 ± 7g were used in a feeding trial for 56 days .The present study aimed to ascertain the effect of feeding diets containing different levels of Moringa oleifera leaves meal (MOLM) asa substitution forsoya bean meal on growth performance, nutrients digestibility,haematological and biochemical blood parameters and carcass traits of rabbits.Therabbits were randomly divided into three experimental groups of 24 rabbits per each and they distributed on three different pelleted diets containing 0, 12.5 and 19 % MOLM to substitute 0, 50 and 75 % of soya bean meal in the basal diet,respectively.The results of the study revealed that chemical composition (%) ofcomposite sample of MOLM resulted from 6 successive cuts of moringa plants recorded: 90.03 DM, 27.44 CP, 8.13 EE, 8.77 CF, 34.63 NFE and 11.06 %Ash, indicating high crude protein, fats and minerals contents in MOLM.The final body weight (FW), daily weight gain (DWG) and relative growth rate (RGR) were insignificantly increasedwith rabbits fed MOLM diets. Feed intake was significantly (P<0.01)declined with rabbits fed 19 % MOLM diet than those fed control or 12.5 % MOLM diet. However, Feed conversion ratio (FCR), growth performance index (GPI) and economic efficiency were significantly (P<0.01) improved with rabbits fed MOLM diets compared with those fed the control diet.Crude protein (CP) and OM digestibility coefficients and nutritive value (%) of MOLM diets expressed as DCP and TDN were significantly higher (P < 0.01) with rabbits fed MOLM diets than with 636 ABO EL-HADED et al.those fed the control diet, while EE, CF and NFE digestibility coefficients were not affected by the dietary treatments.The haematological and biochemical blood parameters were not significantly affected by the dietary treatments, with exception of RBCs, total proteinand globulin which were significantly (P < 0.01) higher, whereas MCH and cholesterol levels were significantly (P < 0.05) lower with rabbits fed MOLM diets. However, all the haematological and biochemical parameters values of rabbit groups were within the normal physiological range.Carcass traits were not significantly influenced by the dietary treatments. Internal organs of rabbits in all groups, including liver, kidney, heart, lungs and spleen appeared normal in size and did not show any signs of toxicity.Conclusively, the results of the present study suggest that MOLM possess good protein quality for growth of rabbits and can be incorporated in the growing rabbits diets up to 19% in replacement up to 75 % of soya bean meal without any detrimental effects on growth performance, nutrients utilization, blood constituents and carcass traits.