Feeding pigs amino acids as protein-bound or in free form influences postprandial concentrations of amino acids, metabolites, and insulin

Eugenio, Francis Amann; Milgen, Jaap van; Duperray, Joël; Sergheraert, Renaud; Floc'H, Nathalie Le

doi:10.1016/j.animal.2022.100684

Cited by 10 publications

(4 citation statements)

References 30 publications

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“…Possibly, reduced ADFI at high AA substitution was caused by increased insulin release. Feeding peptide-bound AA resulted in lower plasma insulin concentrations than feeding free AA in pigs, (8) and intracerebroventricular insulin administration had anorexic effects in broiler chickens (32) . However, insulin was not determined in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…These factors may mute peaks of AA entering the systemic circulation (16) . Further, the availability of AA may act as an anabolic signal leading to protein synthesis (8) . Such an effect would support a high NUE despite temporarily high amounts of AA in the systemic circulation.…”

Section: Effects On Growth and Nitrogen Metabolismmentioning

confidence: 99%

“…When AA are provided as free AA, no peptides need to be hydrolysed by digestive processes and the AA are directly available for absorption in the small intestine (3) . Studies on broiler chickens (4) , pigs (5)(6)(7)(8) , rats (9)(10)(11)(12)(13) and humans (10) found that free AA are absorbed more rapidly into the systemic circulation than peptide-bound AA. With different absorption rates, AA may be available in an unbalanced pattern for protein synthesis even though dietary AA supply is formulated as balanced.…”

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confidence: 99%

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The influence of substituting dietary peptide-bound with free amino acids on nitrogen metabolism and acid–base balance of broiler chickens depends on asparagine and glutamine supply

et al. 2023

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Reducing dietary crude protein (CP) concentration while maintaining adequate amino acid (AA) supply by free AA inclusion can contribute to attenuate the negative environmental effects of animal farming. This study investigated upper limits of dietary free AA inclusions without undesirable effects including the dependence on asparagine (Asn) and glutamine (Gln) supply. Ten broilers were allocated to 63 metabolism units each and offered 9 experimental diets from day (d) 7–21 (n=7). One diet (167 g CP/kg) contained 80 g soy protein isolate (SPI)/kg. In the other diets, 25, 50, 75, and 100% of the digestible AA from SPI were substituted with free AA. Digestible Asn+aspartic acid (Asp) and Gln+glutamic acid (Glu) were substituted with Asp/Glu or 50/50 mixes of Asp/Asn and Glu/Gln, respectively. Total excreta were collected from d 11–14 and d 18–21. Growth and nitrogen accretion were unaffected by 25 and 50% substitution without and with free Asn/Gln, respectively, but decreased at higher substitution (P≤0.024). Circulating concentrations of Asp, Glu, and Gln were unaffected by treatment, while Asn decreased at substitution higher than 50% when Asn/Gln were not provided (P≤0.005). Blood gas analysis on d 21 indicated a compensated metabolic acidosis at substitution higher than 50 and 75% without and with free Asn/Gln, respectively (P≤0.017). Results suggest that adding Asn/Gln increased an upper limit for proportion of dietary free AA from 10 to 19% of dietary CP and enabled higher free AA inclusion without affecting the acid-base balance.

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Section: Discussionmentioning

confidence: 99%

Section: Effects On Growth and Nitrogen Metabolismmentioning

confidence: 99%

mentioning

confidence: 99%

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The influence of substituting dietary peptide-bound with free amino acids on nitrogen metabolism and acid–base balance of broiler chickens depends on asparagine and glutamine supply

et al. 2023

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“…La aparición de aminoácidos en el plasma fue más lenta con la dieta tradicional debido a la digestión. La excreción de urea fue mayor con la dieta tradicional, mientras que la eficiencia de uso del nitrógeno fue mayor con la dieta hecha con aminoácidos libres, evidenciando que la disminución de la proteína en la dieta y el uso de aminoácidos libres es una estrategia para mejorar el rendimiento de la producción y la disminución de la contaminación ambiental (Eugenio et al, 2023).…”

Section: Tasa De Síntesis De Proteínaunclassified

Nutrición animal: Texto de formación universitaria

Huanca¹

2023

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El texto que se pone a consideración del lector, en su edición digital, revisada y corregida, ha sido preparado con fines académicos, para la formación de médicos veterinarios y/o zootecnistas, en el contexto del Altiplano de Puno-Perú; sin embargo, puede servir como referencia para todo lector interesado en la nutrición animal. Incluye seis unidades temáticas: fisiología digestiva de los animales, como uno de los procesos nutricionales clave, seguida de energía (carbohidratos), lípidos, proteínas, minerales y vitaminas, y una unidad temática adicional sobre la evaluación de la composición química y calorimetría de los alimentos.

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Fasting time after feeding affects the evaluation of metabolic response in abalone Haliotis discus hannai to nutrients using dietary methionine as an example

Liu,

Chen,

Fan

et al. 2025

Aquaculture

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Feeding pigs amino acids as protein-bound or in free form influences postprandial concentrations of amino acids, metabolites, and insulin

Cited by 10 publications

References 30 publications

The influence of substituting dietary peptide-bound with free amino acids on nitrogen metabolism and acid–base balance of broiler chickens depends on asparagine and glutamine supply

The influence of substituting dietary peptide-bound with free amino acids on nitrogen metabolism and acid–base balance of broiler chickens depends on asparagine and glutamine supply

Nutrición animal: Texto de formación universitaria

Fasting time after feeding affects the evaluation of metabolic response in abalone Haliotis discus hannai to nutrients using dietary methionine as an example

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