Feeding rainbow trout with a lipid-enriched diet: effects on fatty acid sensing, regulation of food intake, and cellular signaling pathways

Librán-Pérez, Marta; Geurden, Inge; Dias, Karine; Corraze, Généviève; Panserat, Stéphane; Soengas, José L.

doi:10.1242/jeb.123802

Cited by 55 publications

(47 citation statements)

References 54 publications

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“…These changes are not consistent with the few studies available in mammals showing that nesfatin-1 treatment upregulates CREB in a neural cell line (76) and reduces the phosphorylation of mTOR in the dorsal motor nucleus of the vagus (77). However, they are similar to those observed when levels of glucose and/or fatty acids increase in fish (16, 78), a scenario that would match the expected effects for an anorectic signal such as nesfatin-1. In the hypothalamus, only phosphorylation status of AMPKα was affected by nesfatin-1 and in the opposite direction than in the hindbrain.…”

Section: Discussionsupporting

confidence: 71%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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Nesfatin-1 is an 82 amino acid peptide that has been involved in a wide variety of physiological functions in both mammals and fish. This study aimed to elucidate the role of nesfatin-1 on rainbow trout food intake, and its putative effects on glucose and fatty acid sensing systems. Intracerebroventricular administration of 25 ng/g nesfatin-1 resulted in a significant inhibition of appetite, likely mediated by the activation of central POMC and CART. Nesfatin-1 stimulated the glucosensing machinery (changes in sglt1, g6pase, gsase, and gnat3 mRNA expression) in the hindbrain and hypothalamus. Central fatty acid sensing mechanisms were unaltered by nesfatin-1, but this peptide altered the expression of mRNAs encoding factors regulating lipid metabolism (fat/cd36, acly, mcd, fas, lpl, pparα, and pparγ), suggesting that nesfatin-1 promotes lipid accumulation in neurons. In the liver, intracerebroventricular nesfatin-1 treatment resulted in decreased capacity for glucose use and lipogenesis, and increased the potential of fatty acid oxidation. Altogether, the present results demonstrate that nesfatin-1 is involved in the homeostatic regulation of food intake and metabolism in fish.

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Section: Discussionsupporting

confidence: 71%

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

et al. 2018

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“…#T2949. All these antibodies cross-react successfully with the proteins of interest in rainbow trout (Skiba-Cassy et al, 2009; Sánchez-Gurmaches et al, 2010; Kamalam et al, 2012; Librán-Pérez et al, 2015; Velasco et al, 2016). After washing, membranes were incubated with an IgG-HRP secondary antibody ref.…”

Section: Methodsmentioning

confidence: 99%

Feeding Stimulation Ability and Central Effects of Intraperitoneal Treatment of L-Leucine, L-Valine, and L-Proline on Amino Acid Sensing Systems in Rainbow Trout: Implication in Food Intake Control

et al. 2018

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To continue gathering knowledge on the central regulation of food intake in response to amino acids in teleost fish, using as a model rainbow trout (Oncorhynchus mykiss), we evaluated in a first experiment the feeding attractiveness of L-leucine, L-valine, and L-proline offered as an agar gel matrix. In a second experiment, we assessed the effect of intraperitoneal (IP) treatment with the same amino acids on food intake. In a third experiment, we carried out a similar IP administration of amino acids to evaluate the response of amino acid sensing mechanisms in the hypothalamus and telencephalon. Results are discussed in conjunction with an earlier study where leucine and valine were administered intracerebroventricularly (ICV). The attractiveness of amino acids does not appear to relate to their effects on food intake, at least when administrated by-passing ingestion and luminal absorption, since two attractive amino acids resulted in an anorexigenic (Leu) or no effects (Pro) on food intake while a non-attractive amino acid (Val) induced anorexigenic (IP treatment) or orexigenic (ICV treatment) responses. The effects of Leu on food intake might relate to the expression of hypothalamic neuropeptides and result from the direct activation of amino acid sensing systems. In contrast, while valine had few effects on hypothalamic amino acid sensing systems after ICV treatment, a significant amount of parameters become affected by IP treatment suggesting that the effect of Val after IP treatment is indirect. Proline had no relevant effects on amino acid sensing systems, neuropeptide expression, and food intake, which suggest that this amino acid might not have a relevant role in the homeostatic regulation of food intake through hypothalamic mechanisms. In telencephalon, the same amino acid sensing systems operating in hypothalamus appear to be present and respond to Leu and Val, but it is still unclear how they might relate to the control of food intake.

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“…Feeding diets enriched in lipids also induced a decrease in NPY mRNA abundance in grass carp (Li et al, 2010) but not in rainbow trout (Figueiredo-Silva et al, 2012c; Librán-Pérez et al, 2015b) or orange-spotted grouper (Tang et al, 2013). Finally, AgRP mRNA abundance did not change in Atlantic salmon (Hevrøy et al, 2012) but decreased in rainbow trout (Librán-Pérez et al, 2015b) fed with lipid-enriched diets.…”

Section: Impact Of Nutrient Sensing On Food Intake Regulationmentioning

confidence: 99%

“…Therefore, not surprisingly, many studies evaluated the effects of different dietary lipids in fish metabolism (Morash et al, 2009; Torstensen et al, 2009; Sánchez-Gurmaches et al, 2010; Figueiredo-Silva et al, 2012a,b,c; Martinez-Rubio et al, 2013). However, only recent studies provide evidence for the presence of fatty acid sensing systems in central areas of rainbow trout (Librán-Pérez et al, 2012, 2013a, 2014a,b, 2015a,b) and Senegalese sole (Conde-Sieira et al, 2015a) as well as in peripheral areas of rainbow trout (Librán-Pérez et al, 2012, 2013a,b,c, 2015c). …”

Section: Nutrient Sensing Mechanisms In Fishmentioning

confidence: 99%

“…Feeding fish with these diets resulted in increased mRNA abundance of POMC in rainbow trout (Librán-Pérez et al, 2015b), and increased mRNA abundance of CART in rainbow trout (Figueiredo-Silva et al, 2012c; Librán-Pérez et al, 2015b) and Atlantic salmon (Hevrøy et al, 2012). Feeding diets enriched in lipids also induced a decrease in NPY mRNA abundance in grass carp (Li et al, 2010) but not in rainbow trout (Figueiredo-Silva et al, 2012c; Librán-Pérez et al, 2015b) or orange-spotted grouper (Tang et al, 2013). Finally, AgRP mRNA abundance did not change in Atlantic salmon (Hevrøy et al, 2012) but decreased in rainbow trout (Librán-Pérez et al, 2015b) fed with lipid-enriched diets.…”

Section: Impact Of Nutrient Sensing On Food Intake Regulationmentioning

confidence: 99%

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Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

2017

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Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fish species), and intestine] locations whereas fatty acid sensors seem to be present in hypothalamus, liver and BB. Glucose and fatty acid sensing capacities relate to food intake regulation and metabolism in fish. Hypothalamus is as a signaling integratory center in a way that detection of increased levels of nutrients result in food intake inhibition through changes in the expression of anorexigenic and orexigenic neuropeptides. Moreover, central nutrient sensing modulates functions in the periphery since they elicit changes in hepatic metabolism as well as in hormone secretion to counter-regulate changes in nutrient levels detected in the CNS. At peripheral level, the direct nutrient detection in liver has a crucial role in homeostatic control of glucose and fatty acid whereas in BB and intestine nutrient sensing is probably involved in regulation of hormone secretion from endocrine cells.

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Feeding rainbow trout with a lipid-enriched diet: effects on fatty acid sensing, regulation of food intake, and cellular signaling pathways

Cited by 55 publications

References 54 publications

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Nesfatin-1 Regulates Feeding, Glucosensing and Lipid Metabolism in Rainbow Trout

Feeding Stimulation Ability and Central Effects of Intraperitoneal Treatment of L-Leucine, L-Valine, and L-Proline on Amino Acid Sensing Systems in Rainbow Trout: Implication in Food Intake Control

Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis

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