Feeding Regimens and Necrotising Enterocolitis

Meyer, Sascha; Butte, Mona

doi:10.1159/000346118

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…Therefore, the BAER abnormalities seen in the NEC babies must be attributed to NEC and perinatal conditions that are often associated with NEC, including hypoxia-ischemia, low birth weight, inflammation, nutritional deficiencies, etc. [9,10,11]. These unfavorable conditions may damage the immature brainstem and auditory pathway, resulting in BAER abnormalities [14].…”

Section: Discussionmentioning

confidence: 99%

“…The unfavorable perinatal factors that are often associated with NEC (e.g. cerebral prematurity, early nutrition deprivation, systematic infection episode) can adversely affect the immature brain, resulting neurological impairment and developmental abnormality [7,9,10,11]. Recently, Jiang et al [12] reported a first study of brainstem auditory evoked response (BAER) in preterm NEC babies.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Brainstem Auditory Evoked Response at Different Click Rates between Preterm Babies after Neonatal Necrotizing Enterocolitis and Healthy Preterm Babies

Ping¹,

Jiang²

2014

Neonatology

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Background: Neonatal necrotizing enterocolitis (NEC) is associated with an increased incidence of poor neurodevelopment. The knowledge of underlying neurophysiology is very limited, and the influence of NEC on the preterm brainstem is very poorly understood. Objective: To assess the effect of NEC on the immature auditory brainstem by excluding any possible confounding effect of preterm birth. Methods: We recorded and analyzed brainstem auditory evoked response (BAER) at different click rates in preterm babies (30-34 weeks gestation) after NEC. The results were compared with those in age-matched healthy preterm babies who had no NEC. Results: At click rate 21/s, the latencies of BAER waves I and III in the preterm NEC babies were similar to those babies without NEC. However, wave V latency was longer in the NEC babies than in those without NEC. The I-V interpeak interval was also longer in the NEC babies than in those without NEC. These abnormalities were persistent at higher click rates 51 and 91/s. Wave I amplitude in the preterm NEC babies did not differ significantly from that in those without NEC, but wave III and V amplitudes were smaller than in those without NEC at all 21-91/s clicks. Conclusions: Compared with healthy preterm babies, preterm babies after NEC showed a major increase in wave V latency and I-V interval at all 21-91/s clicks. Brainstem auditory function is impaired in preterm NEC babies after excluding the possible confounding effect of preterm birth. Neonatal NEC and associated perinatal conditions adversely affect the premature brainstem.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Brainstem Auditory Evoked Response at Different Click Rates between Preterm Babies after Neonatal Necrotizing Enterocolitis and Healthy Preterm Babies

Ping¹,

Jiang²

2014

Neonatology

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“…The letter that was recently published by Meyer and Butte [1] after the publication of Maas et al [2] may cause some confusion for neonatologists who care for very low birth weight (VLBW) infants. Their apparent very low incidence of NEC is interesting, but the association of this with a delayed and slow feeding policy is questionable and is not evidence-based.…”

mentioning

confidence: 99%

“…Several different factors are involved in its pathophysiology including genetics, altered microbiotia and an immature intestinal barrier [7]. Actual feeding practices are still mainly influenced by local knowledge, experiences and culture, and an excessive fear of NEC frequently leads to late introduction and slow advancement of enteral feeding [1,8]. This practice is associated with an increased need for parenteral nutrition, prolonged duration of intravenous lines, a higher incidence of late-onset sepsis and adverse long-term outcomes [9].…”

mentioning

confidence: 99%

Feeding Regimens and Necrotizing Enterocolitis

Senterre

2013

Neonatology

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“…Meyer and Butte and their team have to be congratulated on the exceptionally low rate of necrotizing enterocolitis (NEC) in very low birth weight infants observed in their department over the last 10 years while practicing slow feeding advancement [1]. …”

mentioning

confidence: 99%