Feeding-related activity of glucose-and morphine-sensitive neurons in the monkey amygdala

Nakano, Yasuhiko; Osuga, Yutaka; Lénárd, László; Nishino, Hitoo; Aou, Shuji; Yamamoto, Tomoya; Aoyagi, Kazuhiko

doi:10.1016/0006-8993(86)90613-x

Cited by 70 publications

(24 citation statements)

References 17 publications

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“…Indeed, numerous GR neurones are found in the ventromedial hypothalamic nucleus (Ashford et al, 1990;Lee et al, 1999;Ono et al, 1982;Oomura et al, 1969) in which few GLUT2-immunoreactive structures have been detected, whereas both GR and GS neurones are present in the lateral hypothalamus and dorsomedial medulla oblongata (Kow and Pfaff, 1989;Mizuno and Oomura, 1984;Oomura et al, 1974;Pénicaud et al, 1990;Silver and Erecinska, 1998;Yettefti et al, 1995Yettefti et al, , 1997 which are richer in GLUT2-immunoreactive structures. On the other hand, both GLUT2-immunoreactive profiles and GS neurones are located in numerous brain areas related to the limbic system, including the arcuate and lateral hypothalamic nuclei, the centromedial amygdala, the hippocampus, different basal ganglia nuclei and the dorsomedial medulla oblongata (McCaleb and Myers, 1979;Mizuno and Oomura, 1984;Muroya et al, 1999;Nakano et al, 1986;Oomura et al, 1974;Ritter et al, 1981;Saller and Chiodo, 1980;Uemura et al, 1989). In contrast, some brain areas not classically endowed with glucosensitive neurones (including the nucleus accumbens, dorsal endopiriform nucleus, temporal and perirhinal cortices and caudo-ventral medulla oblongata) exhibit numerous GLUT2-immunoreactive profiles.…”

Section: Discussionmentioning

confidence: 99%

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study

Arluison

Quignon

Nguyên

et al. 2004

Journal of Chemical Neuroanatomy

136

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Section: Discussionmentioning

confidence: 99%

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study

Arluison

Quignon

Nguyên

et al. 2004

Journal of Chemical Neuroanatomy

136

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“…Karadi et al (1992) and Nakano et al (1986) report that LH cells tend to respond to the deprivation of a given metabolite in the same way they respond to the taste of that metabolite. Ono and associates (1986a) show that LH cells respond in similar fashion to food rewards and the conditioned stimuli that predict them.…”

Section: Model Inputs and Outputs The Neural Model Inmentioning

confidence: 99%

Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation

2008

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“…Glucosensing neurons constitute 10-40% of the resident neuronal populations of the VMH and lateral hypothalamic area (LHA) (1,2,15,17). In addition, glucosensing neurons have been discovered in other brain areas including the amygdala (18), locus ceruleus (19), and nucleus tractus solitarius (20). Two distinct types of neuronal responses to changes in glucose concentrations have been observed, leading to characterization of the neurons as either glucose-responsive or glucose-sensitive.…”

mentioning

confidence: 99%

Localization of glucokinase gene expression in the rat brain.

et al. 2000

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The brain contains a subpopulation of glucosensing neurons that alter their firing rate in response to elevated glucose concentrations. In pancreatic ␤-cells, glucokinase (GK), the rate-limiting enzyme in glycolysis, mediates glucose-induced insulin release by regulating intracellular ATP production. A similar role for GK is proposed to underlie neuronal glucosensing. Via in situ hybridization, GK mRNA was localized to hypothalamic areas that are thought to contain relatively large populations of glucosensing neurons (the arcuate, ventromedial, dorsomedial, and paraventricular nuclei and the lateral area). GK also was found in brain areas without known glucosensing neurons (the lateral habenula, the bed nucleus stria terminalis, the inferior olive, the retrochiasmatic and medial preoptic areas, and the thalamic posterior paraventricular, interpeduncular, oculomotor, and anterior olfactory nuclei). Conversely, GK message was not found in the nucleus tractus solitarius, which contains glucosensing neurons, or in ependymal cells lining the third ventricle, where others have described its presence. In the arcuate nucleus, >75% of neuropeptide Y-positive neurons also expressed GK, and most GK + neurons also expressed KIR6.2 (the pore-forming subunit of the ATP-sensitive K + channel). The anatomic distribution of GK mRNA was confirmed in micropunch samples of hypothalamus via reverse transcription-polymerase chain reaction (RT-PCR). Nucleotide sequencing of the recovered PCR product indicated identity with nucleotides 1092-1411 (within exon 9 and 10) of hepatic and ␤-cell GK. The specific anatomic localization of GK mRNA in hypothalamic areas known to contain glucosensing neurons and the coexpression of KIR6.2 and NPY in GK + neurons support a role for GK as a primary determinant of glucosensing in neuropeptide neurons that integrate multiple signals relating to peripheral energy metabolism. Diabetes 49:693-700, 2000 M ammalian feeding behavior and general energy homeostasis appear to be regulated by circulating levels of nutrients (glucose) and peptides (e.g., leptin, insulin). Sensors to detect levels of these factors have been found to reside within specific nuclei of the hypothalamus (1-8), where central regulation of energy homeostasis is believed to be coordinated. For example, large changes in blood glucose are correlated with centrally mediated responses such as thermogenesis through activation of the sympathetic nervous system. These changes are monitored by the brain (9-11), and such responses are altered in obesity-prone animals (11-13). Moreover, lesions of the ventromedial hypothalamus (VMH) prevent the hypoglycemic activation of the sympathetic response (14). Thus, available data indicate that glucose detection by hypothalamic neurons may play an important role in regulating energy homeostasis.Glucosensing neurons are among the best characterized of such metabolic sensors. Unlike most neurons, they use glucose as a signaling molecule to alter their firing rate in response to changes in ambient glucose le...

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Feeding-related activity of glucose-and morphine-sensitive neurons in the monkey amygdala

Cited by 70 publications

References 17 publications

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study

Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain—an immunohistochemical study

Dopaminergic and non-dopaminergic value systems in conditioning and outcome-specific revaluation

Localization of glucokinase gene expression in the rat brain.

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