Feeding tannins to dairy cows in different seasons improves the oxidative status of blood plasma and the antioxidant capacity of cheese

Santillo, Antonella; Ciliberti, Maria Giovanna; Ciampi, F.; Luciano, Giuseppe; Natalello, Antonio; Menci, Ruggero; Caccamo, M.; Sevi, A.; Albenzio, Marzia

doi:10.3168/jds.2022-22256

Cited by 13 publications

(11 citation statements)

References 56 publications

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“…In line with our results, the tannic acid is able to modulate the immune responses of whole blood cells in sheep stimulated by Haemonchus contortus crude larval antigen by shifting the Th1 cytokines versus Th2 cytokine expression levels in cells ( 48 ). Consistently, in grazing dairy cows receiving supplementation with tannins ( 49 ), a suppressive action of tannins on IL-1β Th1 cytokines coupled with the increased level of IL-10 is found. Taking into account data on the cytokines’ profile of growing lambs, a role for HS in modulating cytokine secretion in favor of the regulatory/anti-inflammatory IL-10 could be assumed.…”

Section: Discussionmentioning

confidence: 63%

Role of hazelnut skin supplementation on plasma antioxidant status and cytokine profile in growing lambs

Ciliberti,

Santillo,

Caroprese

et al. 2024

Front. Vet. Sci.

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In this study, the effect of hazelnut skin dietary supplementation on antioxidant status and cytokine profile was evaluated in growing lambs. A total of 22 male lambs at the age of 2 months, balanced for their initial live weight (15.33 ± SD 1.79 kg), were selected and allocated into two experimental groups: the control group (CON) receiving a maize-barley-based concentrated diet, and the hazelnut group (HS) receiving supplementation with hazelnut skin (150 g/kg on the dry matter) as a maize substitute for the concentrate diet. The experiment lasted for 56 days. Peripheral blood was collected at 7, 35, and 56 days of the experiment. The free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, the total antioxidant capacity assay (TAC), the reactive oxygen species (ROS), and reactive nitrogen species (RNS) were determined in plasma. The secretion of IL-1β, IL-6, and IL-10 cytokines was also determined by ELISA. The DPPH was affected by the interaction between feeding strategy and time of sampling (p = 0.039) with a higher level of DPPH at 7 days in the HS group than the CON group. The time of sampling affected the levels of plasma TAC (p = 0.016), while the ROS/RNS levels showed a higher value in the HS group (p < 0.001), on average. The antioxidant/oxidant index, which combines the TAC and the ROS/RNS levels, was not affected by the inclusion of hazelnut skin in the diet (p = 0.394). The cytokine profile showed a lower IL-6 secretion at both 35 and 56 days than at 7 days, on average. Furthermore, the feeding treatment affected the IL-1β level, showing a lower level in the HS group than in the CON group on average. Lambs from the HS group had higher IL-10 plasma levels than the CON group at 7 days of the experiment. The present data highlight an antioxidant effect and a modulatory role in the cytokine profile of HS supplementation in growing lambs.

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Section: Discussionmentioning

confidence: 63%

Role of hazelnut skin supplementation on plasma antioxidant status and cytokine profile in growing lambs

Ciliberti,

Santillo,

Caroprese

et al. 2024

Front. Vet. Sci.

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“…The chemical structure of tannin, including the O-dihydroxy structure in the B ring and the galloyl groups, might be involved in the activity of inhibiting lipid peroxidation, suggesting that they are important determinants for radical scavenging and antioxidative potential [ 42 ]. Previous studies have shown that supplementing TAN in the diet can enhance antioxidant capacity in the plasma or liver of dairy cows [ 43 ] and goats [ 44 ]. While past research has seldom reported on the ability of dietary TAN to mitigate lipid peroxidation in the liver of beef cattle, our study presents a novel finding in this regard.…”

Section: Discussionmentioning

confidence: 99%

“…The potential of TAN to inhibit liver lipid peroxidation in beef cattle may be attributed to its gallic acid composition. This component can scavenge free radicals and bolster endogenous antioxidant defense mechanisms against them [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of Tannic Acid Promotes Performance of Beef Cattle via Alleviating Liver Lipid Peroxidation and Improving Glucose Metabolism and Rumen Fermentation

He,

Yi,

et al. 2023

Antioxidants

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This study aimed to investigate the effects of dietary tannic acid (TAN) on the gas production, growth performance, antioxidant capacity, rumen microflora, and fermentation function of beef cattle through in vitro and in vivo experiments. TAN was evaluated at 0.15% (dry matter basis, DM) in the in vitro experiment and 0.20% (DM basis) in the animal feeding experiment. The in vitro results revealed that compared with control (CON, basal diet without TAN), the addition of TAN significantly increased the cumulative gas production and asymptotic gas production per 0.20 g dry matter substrate (p < 0.01), with a tendency to reduce methane concentration after 96 h of fermentation (p = 0.10). Furthermore, TAN supplementation significantly suppressed the relative abundance of Methanosphaera and Methanobacteriaceae in the fermentation fluid (LDA > 2.50, p < 0.05). The in vivo experiment showed that compared with CON, the dietary TAN significantly improved average daily gain (+0.15 kg/d), dressing percent (+1.30%), net meat percentage (+1.60%), and serum glucose concentration (+23.35%) of beef cattle (p < 0.05), while it also significantly reduced hepatic malondialdehyde contents by 25.69% (p = 0.02). Moreover, the TAN group showed significantly higher alpha diversity (p < 0.05) and increased relative abundance of Ruminococcus and Saccharomonas (LDA > 2.50, p < 0.05), while the relative abundance of Prevotellaceae in rumen microbial community was significantly decreased (p < 0.05) as compared to that of the CON group. In conclusion, the dietary supplementation of TAN could improve the growth and slaughter performance and health status of beef cattle, and these favorable effects might be attributed to its ability to alleviate liver lipid peroxidation, enhance glucose metabolism, and promote a balanced rumen microbiota for optimal fermentation.

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“…It is worth noting that the primary effect of resveratrol is its antioxidant action, a characteristic shared with other dietary antioxidants such as tannins and vitamin E [ 47 ], which are also present as supplements in cheese and may contribute to its properties [ 48 ]. Moreover, apart from antioxidants, cheese also contains vitamin D and calcium due to supplementation.…”

Section: Discussionmentioning

confidence: 99%

Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

Tseilikman,

Shatilov,

Zhukov

et al. 2023

IJMS

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Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.

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Feeding tannins to dairy cows in different seasons improves the oxidative status of blood plasma and the antioxidant capacity of cheese

Cited by 13 publications

References 56 publications

Role of hazelnut skin supplementation on plasma antioxidant status and cytokine profile in growing lambs

Role of hazelnut skin supplementation on plasma antioxidant status and cytokine profile in growing lambs

Dietary Supplementation of Tannic Acid Promotes Performance of Beef Cattle via Alleviating Liver Lipid Peroxidation and Improving Glucose Metabolism and Rumen Fermentation

Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

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