Feeding the blend of organic acids and medium chain fatty acids reduces the diarrhea in piglets orally challenged with enterotoxigenic Escherichia coli K88

Lei, Xin Jian; Park, Jae Won; Baek, Dong Heon; Kim, Jong Keun; Kim, In Ho

doi:10.1016/j.anifeedsci.2016.11.016

Cited by 38 publications

(33 citation statements)

References 25 publications

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“…Fecal samples showed higher Lactobacillus levels and lower E. coli levels for both treatment levels (P < 0.05). In subsequent work, Lei et al found that 0.2-0.4% of the same feed additive also improved growth performance of E. coli-challenged piglets [79]. There was a protective effect for infected piglets, as indicated by greater body weight gain, daily feed intake, and FCR (P < 0.05) compared to an untreated control group without additive.…”

Section: Mcfa and Organic Acid Mixturesmentioning

confidence: 93%

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation

Jackman

Boyd

Elrod

2020

J Animal Sci Biotechnol

106

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Ongoing challenges in the swine industry, such as reduced access to antibiotics and virus outbreaks (e.g., porcine epidemic diarrhea virus, African swine fever virus), have prompted calls for innovative feed additives to support pig production. Medium-chain fatty acids (MCFAs) and monoglycerides have emerged as a potential option due to key molecular features and versatile functions, including inhibitory activity against viral and bacterial pathogens. In this review, we summarize recent studies examining the potential of MCFAs and monoglycerides as feed additives to improve pig gut health and to mitigate feed pathogens. The molecular properties and biological functions of MCFAs and monoglycerides are first introduced along with an overview of intervention needs at different stages of pig production. The latest progress in testing MCFAs and monoglycerides as feed additives in pig diets is then presented, and their effects on a wide range of production issues, such as growth performance, pathogenic infections, and gut health, are covered. The utilization of MCFAs and monoglycerides together with other feed additives such as organic acids and probiotics is also described, along with advances in molecular encapsulation and delivery strategies. Finally, we discuss how MCFAs and monoglycerides demonstrate potential for feed pathogen mitigation to curb disease transmission. Looking forward, we envision that MCFAs and monoglycerides may become an important class of feed additives in pig production for gut health improvement and feed pathogen mitigation.

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Section: Mcfa and Organic Acid Mixturesmentioning

confidence: 93%

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation

Jackman

Boyd

Elrod

2020

J Animal Sci Biotechnol

106

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“…Active ingredients such as citric acid, malic acid, fumaric acid, and MCFAs are dispersed in a matrix of shell material, a lipid which can allow the active components to reach the intestine in an intact form, and be released slowly by the reaction of lipase from the intestine thereby showing beneficial effects to animals [10,28]. It has been previously reported that using the same product of protected blend of OA and MCFA supplementation in diets improved growth performance of piglets, and growing and finishing pigs [7,10,29] as well as laying hens [20]. In this study, we also observed that the BWG and FCR were linearly improved when broilers were fed the diets supplemented with the blend of OAs and MCFAs.…”

Section: Growth Performancementioning

confidence: 99%

“…Adding OAs to feed can lower gastric pH which accelerates the conversion of pepsinogen to pepsin, thereby improving the absorption rate of proteins, amino acids, and minerals [6]. This may contribute not only to improving performance but also reducing nitrogen and phosphorus excretion with decreasing environmental pollution [7]. OAs have several additional effects that go beyond those of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Protected Organic Acids Improved Growth Performance, Nutrient Digestibility, and Decreased Gas Emission in Broilers

Nguyen

Kim

2020

Animals

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We investigated the effects of a blend of organic acids (OAs) and medium-chain fatty acids (MCFAs) supplementation in 800 1-d-old male Ross 308 broiler chickens (42 ± 0.90 g) in a 7-week study. Broiler chicks were randomly allocated into one of the five dietary treatments (16 birds per pen with 10 pens per treatment). Dietary treatments consisted of corn-soybean meal based basal diet and the basal diet supplemented with blend of OAs and MCFAs at 0.25, 0.5, 0.75 g, and 1 g per kg of feed. In the current study, during the whole experimental period, the inclusion of the blend of OAs and MCFAs in the basal diet linearly improved (p < 0.05) body weight gain (BWG), feed conversion ratio (FCR), and dry matter digestibility. The increasing inclusion of the blend of OA and MCFA levels in the diets linearly decreased (p = 0.002) feed intake during d 1 to 7. Broilers fed diets containing different levels of the blend of OAs and MCFAs showed a linear increase (p = 0.006) in Lactobacillus concentrations and decrease (p = 0.014) in ammonia (NH3) at the end of the experiment. However, the blend of OAs and MCFAs did not affect carcass quality, E. coli, and Salmonella counts, as well as hydrogen sulfide and total mercaptans gas emission (p > 0.05). In conclusion, the blend of OA and MCFA supplementation positively influenced growth performance, DM digestibility, excreta Lactobacillus counts, as well as NH3 gas emission in broiler chickens.

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“…After weaning, piglets lose the supply of maternal antibodies, and the development of their immune system remains incomplete. Thus, weanling pigs are particularly vulnerable to the invasion of exogenous pathogenic bacteria and viruses, leading to diarrhea, growth retardation, and even death [23]. The growth of animals is subjected to the combined effects of a progression of anabolism and catabolism.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Supplementation with Mulberry (Morus alba L.) Leaf Polysaccharides on Immune Parameters of Weanling Pigs

Zhao

Yang

et al. 2019

Animals

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Simple Summary: The increasing overuse/misuse of restricted antibiotics in livestock and poultry production has raised a serious health concern. Thus, aiming to improve animals' health levels, researchers are redirecting their focus onto naturally occurring bioactive ingredients from plants; these compounds have become a potential substitute for antibiotics. Mulberry leaf polysaccharide (MLP) is an important bioactive component, which has notable potential for improving animal immunity. In this context, the present study was designed to investigate the MLPs' effect on animals' metabolisms and the immune parameters of weanling pigs.Abstract: In this study, the effect of dietary supplementation of mulberry leaf polysaccharides (MLPs) on the immune parameters-i.e., the immune organ weight, serum immunoglobulins, cytokines, nitric oxide (NO) production, and insulin-Like growth factor-1 (IGF1) mRNA expression-of weanling pigs as a model animal was investigated. A total of 120 healthy weanling pigs (aged 28 ± 2 d) with the same body weights were randomly divided into four groups: (1) Control treatment (CT), basal diet (BD), (2) MLP low-dose treatment (MLT), 0.6 g/kg MLP + BD, (3) MLP high-dose treatment (MHT), 1.2 g/kg MLP + BD, and (4) antibiotic treatment (AT), 0.15 g/kg chlortetracycline + BD. The results revealed that the thymus and spleen indices were significantly increased (P < 0.05) in both MLT and MHT groups in comparison with the CT group, while the serum levels of immunoglobulin G (IgG), interleukin (IL)-1β, IL-2, IL-8, and interferon (IFN-γ) in the MLT group and IL-2, IL-6, and IFN-γ in the MHT group were also considerably greater (P < 0.05) than the corresponding levels in the CT group. The serum contents of IgG, IL-1β, IL-2, and IL-8 in the MLT group and IL-2 and IL-6 in the MHT group were significantly increased in comparison with the corresponding contents in the AT group (P < 0.05). The transformation rate of lymphocytes in the MLT and MHT groups was higher compared to the CT and AT groups. However, a notable difference was found between the MLT group and the two control groups. The peripheral lymphocyte NO production in the MLT, MHT, and AT groups was significant relative to the CT group. The expression levels of IGF1 mRNA in the liver and muscle longissimus tissues of both the MLT and MHT groups showed significant improvement (P < 0.05) over those in the CT group. Moreover, the IGF1 mRNA expression in the muscle longissimus from the MLT group was significantly higher than in the AT group. In conclusion, the results suggest that incorporating MLPs into the diets of weanling pigs improves the animals' metabolisms and immune functions, and the effects of the MLT group were superior to those of both the MHT and AT groups.

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Feeding the blend of organic acids and medium chain fatty acids reduces the diarrhea in piglets orally challenged with enterotoxigenic Escherichia coli K88

Cited by 38 publications

References 25 publications

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation

Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation

Protected Organic Acids Improved Growth Performance, Nutrient Digestibility, and Decreased Gas Emission in Broilers

Effects of Dietary Supplementation with Mulberry (Morus alba L.) Leaf Polysaccharides on Immune Parameters of Weanling Pigs

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