Feeding Time Entrains the Olfactory Bulb Circadian Clock in Anosmic PER2::LUC Mice

Pavlovski, Ilya; Evans, Jennifer; Mistlberger, Ralph E.

doi:10.1016/j.neuroscience.2018.10.009

Cited by 12 publications

(6 citation statements)

References 43 publications

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“…The methylated genes demonstrated olfactory activity pathways upregulation in multiple tissues ( Figure 7D). The olfactory bulb pathways are closely linked to circadian rhythm affecting feeding times (Pavlovski et al, 2018) and immune functions (Mukhopadhyay et al, 2016). Additionally, mitochondrial Ca(2+) is a critical element in olfactory signaling (Fluegge et al, 2012), and in astronauts, smelling behavior changes occur potentially due to microgravity causing an upward shift of body fluid (Mukhopadhyay et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Silveira

Fazelinia

Rosenthal

et al. 2020

Cell

244

191

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Section: Discussionmentioning

confidence: 99%

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Silveira

Fazelinia

Rosenthal

et al. 2020

Cell

244

191

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“…An important consideration related to early versus late feeding is the influence of feeding on the internal circadian clock [68,69,70,71]. The body circadian timing system is composed by a central clock in the hypothalamic suprachiasmatic nucleus and by different peripheral tissue clocks.…”

Section: Meal Timingmentioning

confidence: 99%

The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting

et al. 2019

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The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospective research has demonstrated a significant increase in disease risk with a high meal frequency (≥6 meals/day) as compared to a low meal frequency (1–2 meals/day). Apart from meal frequency and timing we also have to consider breakfast consumption and the distribution of daily energy intake, caloric restriction, and night-time eating. A central role in this complex scenario is played by the fasting period length between two meals. The physiological underpinning of these interconnected variables may be through internal circadian clocks, and food consumption that is asynchronous with natural circadian rhythms may exert adverse health effects and increase disease risk. Additionally, alterations in meal frequency and meal timing have the potential to influence energy and macronutrient intake.A regular meal pattern including breakfast consumption, consuming a higher proportion of energy early in the day, reduced meal frequency (i.e., 2–3 meals/day), and regular fasting periods may provide physiological benefits such as reduced inflammation, improved circadian rhythmicity, increased autophagy and stress resistance, and modulation of the gut microbiota

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“…However, it is not only the timing but also the quality and quantity of ingredients that control the peripheral oscillators (Vollmers et al 2009, Laermans et al 2014, Pavlovski et al 2018. While the central clock regulates food intake, energy expenditure, and insulin sensitivity, the peripheral tissue clocks are also believed to exert additional control over glucose uptake and secretion, insulin sensitivity, lipid biosynthesis, and catabolism.…”

Section: Food and Metabolismmentioning

confidence: 99%

Fixing the broken clock in adrenal disorders: focus on glucocorticoids and chronotherapy

Minnetti

Hasenmajer

Pofi

et al. 2020

Journal of Endocrinology

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The circadian rhythm derives from the integration of many signals that shape the expression of clock-related genes in a 24-h cycle. Biological tasks, including cell proliferation, differentiation, energy storage, and immune regulation, are preferentially confined to specific periods. A gating system, supervised by the central and peripheral clocks, coordinates the endogenous and exogenous signals and prepares for transition to activities confined to periods of light or darkness. The fluctuations of cortisol and its receptor are crucial in modulating these signals. Glucocorticoids and the autonomous nervous system act as a bridge between the suprachiasmatic master clock and almost all peripheral clocks. Additional peripheral synchronizing mechanisms including metabolic fluxes and cytokines stabilize the network. The pacemaker is amplified by peaks and troughs in cortisol and their response to food, activity, and inflammation. However, when the glucocorticoid exposure pattern becomes chronically flattened at high- (as in Cushing’s syndrome) or low (as in adrenal insufficiency) levels, the system fails. While endocrinologists are well aware of cortisol rhythm, too little attention has been given to interventions aimed at restoring physiological cortisol fluctuations in adrenal disorders. However, acting on glucocorticoid levels may not be the only way to restore clock-related activities. First, a counterregulatory mechanism on the glucocorticoid receptor itself controls signal transduction, and second, melatonin and/or metabolically active drugs and nutrients could also be used to modulate the clock. All these aspects are described herein, providing some insights into the emerging role of chronopharmacology, focusing on glucocorticoid excess and deficiency disorders.

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Feeding Time Entrains the Olfactory Bulb Circadian Clock in Anosmic PER2::LUC Mice

Cited by 12 publications

References 43 publications

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting

Fixing the broken clock in adrenal disorders: focus on glucocorticoids and chronotherapy

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