Feedrate deviations caused by hopper refill of loss-in-weight feeders

Engisch, William E.; Muzzio, Fernando J.

doi:10.1016/j.powtec.2015.06.001

Cited by 84 publications

(46 citation statements)

References 8 publications

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“…For pharmaceutical applications, where the feeding accuracy of the individual raw materials is critical and the density of the processed powders can vary, the gravimetric feeding mode is preferred. A LIW feeder operating in gravimetric mode will switch to volumetric mode during hopper refill, because the weight loss cannot be accurately measured when material is entering and leaving the feeder at the same time (Engisch and Muzzio, 2015b).…”

Section: Introductionmentioning

confidence: 99%

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

Bostijn

Dhondt

Ryckaert

et al. 2019

International Journal of Pharmaceutics

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The UGent Institutional Repository is the electronic archiving and dissemination platform for all UGent research publications. Ghent University has implemented a mandate stipulating that all academic publications of UGent researchers should be deposited and archived in this repository. Except for items where current copyright restrictions apply, these papers are available in Open Access. This item is the archived peer-reviewed author-version of: A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

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Section: Introductionmentioning

confidence: 99%

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

Bostijn

Dhondt

Ryckaert

et al. 2019

International Journal of Pharmaceutics

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“…Engisch et al proposed a method to characterize and evaluate the steady state performance of a loss-in-weight feeder for different powders [11]. Methods to measure feeding performance during hopper refill and to optimize scheduling of refilling have also been presented [12]. Kehlenbeck et al showed improved feeder dosing consistency by using a single proportioning device at the discharge [13].…”

Section: Introductionmentioning

confidence: 99%

Predicting feeder performance based on material flow properties

Wang

Muzzio

et al. 2017

Powder Technology

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Purpose: Accurate and consistent delivery of materials by well-designed feeders ensures overall process stability. Importantly, feeding performance is strongly dependent on material flow properties. The purpose of this study is to develop a methodology that identifies predictive correlation between material flow properties and feeder performance. Method: The proposed methodology includes techniques to characterize material flow properties, methods to quantify feeding performance of a loss-in-weight feeder, and predictive multivariate analysis. Two approaches to correlate feeding performance and material flow properties were examined in the study: principal component analysis, followed by similarity scoring (PCA-SS), and partial least squares regression (PLSR). Results: Experimental results showed that selection of the optimal feeder screw to achieve optimum feeding performance is heavily dependent on material flow properties. Both approaches to predict feeding performance based on material properties were validated. In addition, a strong correlation between the initial feed factor of each material and its flow properties were observed. Conclusion: The work presented here has demonstrated an efficient approach to correlate material properties with gravimetric feeder performance. This approach is especially powerful in the early phase of process and product development, when the amount of a material is limited.

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“…Besides the material flow properties, the feed rate deviations caused by hopper refill are also fairly important in a practical application point of view [145]. During a continuous process, hopper refill has to be solved while the feeder is operating.…”

Section: Importance Of Feeder Selectionmentioning

confidence: 99%

Continuous Formulation Approaches of Amorphous Solid Dispersions: Significance of Powder Flow Properties and Feeding Performance

et al. 2019

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Preparation and formulation of amorphous solid dispersions (ASDs) are becoming more and more popular in the pharmaceutical field because the dissolution of poorly water-soluble drugs can be effectively improved this way, which can lead to increased bioavailability in many cases. During downstream processing of ASDs, technologists need to keep in mind both traditional challenges and the newest trends. In the last decade, the pharmaceutical industry began to display considerable interest in continuous processing, which can be explained with their potential advantages such as smaller footprint, easier scale-up, and more consistent product, better quality and quality assurance. Continuous downstream processing of drug-loaded ASDs opens new ways for automatic operation. Therefore, the formulation of poorly water-soluble drugs may be more effective and safe. However, developments can be challenging due to the poor flowability and feeding properties of ASDs. Consequently, this review pays special attention to these characteristics since the feeding of the components greatly influences the content uniformity in the final dosage form. The main purpose of this paper is to summarize the most important steps of the possible ASD-based continuous downstream processes in order to give a clear overview of current course lines and future perspectives.

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Feedrate deviations caused by hopper refill of loss-in-weight feeders

Cited by 84 publications

References 8 publications

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

Predicting feeder performance based on material flow properties

Continuous Formulation Approaches of Amorphous Solid Dispersions: Significance of Powder Flow Properties and Feeding Performance

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