Feeling of presence in Parkinson's disease

Fénelon, Gilles; Soulas, Thierry; Langavant, Laurent Cléret de; Trinkler, Iris; Bachoud‐Lévi, Anne‐Catherine

doi:10.1136/jnnp.2010.234799

Cited by 101 publications

(123 citation statements)

References 37 publications

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“…We choose to integrate 'guardian angel' item in PSAS because it is a projection of the sensation into the extrapersonal space, along with the frequent co-occurrence of elementary visual hallucinations and the strong association with visual hallucinations or illusions, supporting its hallucinatory nature (Fenelon et al, 2011). Moreover, 'guardian angel' sensations were recognized as common in PD (Sanchez-Ramos et al, 1996) and even described in SCZ (Koehler and Sauer, 1984), and probably underestimated because they were not explored.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Validation of a Psycho-Sensory hAllucinations Scale (PSAS) in schizophrenia and Parkinson's disease

Chazeron

Pereira

Chéreau-Boudet

et al. 2015

Schizophrenia Research

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Section: Discussionmentioning

confidence: 98%

“…A specific item on 'guardian angel', already well described in PD by Fenelon, was added (Fenelon et al, 2011). It defined this feeling of presence to the vivid sensation that somebody is present nearby, when no one is actually there, in the absence of sensory clues revealing a presence.…”

Section: Construction Of the Psasmentioning

confidence: 99%

Validation of a Psycho-Sensory hAllucinations Scale (PSAS) in schizophrenia and Parkinson's disease

Chazeron

Pereira

Chéreau-Boudet

et al. 2015

Schizophrenia Research

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“…Relatedly, RBD in PD or LBD is associated with a lower Braak stage and independently predicts the development of hallucinations (Arnulf, 2013; Dugger et al, 2012). In the early stages of PD 20 to 45% of patients report fleeting sideway shadows (‘passage’ hallucinations) or a sensation of presence (Fénelon, Soulas, Cleret de Langavant, Trinkler, & Bachoud-Levi, 2011; Fénelon, Soulas, Zenasni, & de Langavant, 2010; Mack et al, 2012). Pareidolias and visual hallucinations are common in patients with LBD (Uchiyama et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder

Geddes

Tie

Gabrieli

et al. 2016

Cortex

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Brainstem lesions causing peduncular hallucinosis (PH) produce vivid visual hallucinations occasionally accompanied by sleep disorders. Overlapping brainstem regions modulate visual pathways and REM sleep functions via gating of thalamocortical networks. A 66-year-old man with paroxysmal atrial fibrillation developed abrupt-onset complex visual hallucinations with preserved insight and violent dream enactment behavior. Brain MRI showed restricted diffusion in the left rostrodorsal pons suggestive of an acute ischemic infarct. REM sleep behavior disorder (RBD) was diagnosed on polysomnography. We investigated the integrity of ponto-geniculate-occipital circuits with seed-based resting-state functional connectivity MRI (rs-fcMRI) in this patient compared to 46 controls. Rs-fcMRI revealed significantly reduced functional connectivity between the lesion and lateral geniculate nuclei (LGN), and between LGN and visual association cortex compared to controls. Conversely, functional connectivity between brainstem and visual association cortex, and between visual association cortex and PFC was significantly increased in the patient. Focal damage to the left rostrodorsal pons is sufficient to cause RBD and PH in humans, suggesting an overlapping mechanism in both syndromes. This lesion produced a pattern of altered functional connectivity consistent with disrupted visual cortex connectivity via de-afferentation of thalamocortical pathways.

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“…[567] In addition, there are only limited data on the pattern of psychosis in PD, especially from India. [8] Therefore, the present study was undertaken to study the clinical profile of the patients with Parkinson's disease and psychosis using the neuropsychiatric inventory (NPI) for rating of psychotic symptoms.…”

Section: Introductionmentioning

confidence: 99%

A clinical profile of patients with Parkinson′s disease and psychosis

Amar

Yadav

Reddy

et al. 2014

Ann Indian Acad Neurol

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Aims:The aim of the study was to study the clinical profile of the patients with Parkinson's disease (PD) and psychosis.Settings and Design:This was a prospective, cross sectional, hospital-based study done at the Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India from September 2009 to January 2011. All patients with PD, diagnosed by United Kingdom PD Society Brain Bank criteria, having with features of psychosis as diagnosed by the neuropsychiatric inventory (NPI) were included. Patients without a caregiver who could validate the patient's symptoms were excluded.Results:A total of 40 patients (5 women, 35 men) with PD with psychosis (mean age: 54.2 ± 11.5 years, mean duration of illness: 6.5 ± 4.5 years, and mean duration of psychosis: 4.3 ± 4.3 years) were included in the study. The Global NPI score was 19.1 ± 11.5. Majority of the patients had pure hallucinations (85%), while the rest had either pure delusions (7.5%) or a combination of delusions and hallucinations (7.5%). In those with hallucinations, visual hallucinations were the commonest (60%) (pure only in 22.5%), followed by auditory (45%), minor hallucinations (45%), and tactile (20%). Only one person reported having olfactory hallucinations (2.5%). Loss of insight was most often observed during the visual hallucinations (52%), followed by tactile (44.4%), auditory (38.9 %), and minor hallucinations (33.3%).Conclusions:In patients with PD and psychosis, pure hallucinations are common and visual hallucinations are the commonest among the hallucinations. A large proportion of patients have minor hallucinations, which need to be recognized early for effective and early management. The limitations of the study were small sample size, use of a single scale to assess psychosis and subjective assessment of insight.

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Feeling of presence in Parkinson's disease

Cited by 101 publications

References 37 publications

Validation of a Psycho-Sensory hAllucinations Scale (PSAS) in schizophrenia and Parkinson's disease

Validation of a Psycho-Sensory hAllucinations Scale (PSAS) in schizophrenia and Parkinson's disease

Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder

A clinical profile of patients with Parkinson′s disease and psychosis

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