“Feeling the Blues”: A Case of Calcium Channel Blocker Overdose Managed With Methylene Blue

Pellegrini, James R.; Munshi, Rezwan; Tiwana, Muhammad S.; Abraham, Tinu Ravi; Tahir, Hira; Sayedy, Najia; Iqbal, Javed

doi:10.7759/cureus.19114

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…La causa más frecuente de la vasodilatación generalizada que genera choque suele ser la sepsis. Sin embargo, los agentes antihipertensivos comparten el mismo mecanismo de choque y, (2,11) entre estos fármacos, los BBC suelen ser los más reportados .…”

Section: Discussionunclassified

“…Sin embargo, la hipercalcemia suele generar bradicardia por lo que el monitoreo cardiaco es mandatorio además de la asociación con fármacos vasoactivos. La calcemia de nuestra paciente estaba por debajo del rango y recibió bolos correctores de calcio, algo que pudo haberse administrado en forma de infusión ya que dada la toxicodinámica de (11,16) los BCC es justificado su uso para los cuadros de intoxicación .…”

Section: Discussionunclassified

“…Dado que la intoxicación por BCC activa otras vías de choque como el aumento de NO, se han reportado también el uso de azul de metileno para este tipo de intoxicaciones como coadyuvantes del tratamiento. En este caso no hemos utilizado este fármaco debido a su difícil obtención en nuestro (4,11,12) medio y por la rápida respuesta de la paciente a los fármacos vasopresores e inotrópicos .…”

Section: Discussionunclassified

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Vasoplegic shock due to amlodipine and losartan poisoning

Villasboa

Bejarano

Ayala

2022

Rev. virtual Soc. Parag. Med. Int

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El choque vasodilatado o también llamado distributivo ocurre cuando las arteriolas presentan una pérdida de contractibilidad por diferentes mecanismos en donde la hipoxia y acidosis suelen ser los principales. La causa más común de este tipo de choque es la sepsis. Sin embargo, existen otras causas como las intoxicaciones con fármacos. Presentamos el manejo en la unidad de cuidados intensivos de un caso de intoxicación con fines de autoeliminación con dosis elevadas de antihipertensivos bloqueantes de canales calcio y antagonistas del receptor de angiotensina II, que requirió soporte hemodinámico y respiratorio.

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Section: Discussionunclassified

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Vasoplegic shock due to amlodipine and losartan poisoning

Villasboa

Bejarano

Ayala

2022

Rev. virtual Soc. Parag. Med. Int

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“…This class of drugs causes vasodilation and reduces peripheral resistance by blockage of voltage-gated channels of calcium in vascular smooth muscles. 11 The aims of this study are to estimate the serum calcium level and compression of serum calcium level in patients with essential hypertension with normal control subjects.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Serum Calcium Level in the Patients of Hypertension

Ali¹,

Haque²,

Rauf³

et al. 2022

PJMHS

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Background: Hypertension is one of the leading progressive cause of mortality and morbidity in developed as well as developing countries all over the world. Intracellular and extracellular ions of the body regulate the hemostasis of blood pressure. Objective: To estimate the serum calcium level in the patients of newly diagnosed cases of hypertension with normotensive set of subjects. Methodology: This case comparative study was conducted at the medical OPD of Bilawal Medical College and LUMHS Hospital Hyderabad and Jamshoro. 100 subjects were chosen and divided into two groups: 50 normotensive as a control group and 50 hypertensive as a case study group. Selection of samples was done on the basis of the non-probability technique. A sphygmomanometer was used to measure blood pressure, and a kit method was used to measure serum calcium levels. The statistical analysis of the data was carried out by SPSS version 22 by applying the student t test. Results: The mean age of control group subjects was 44 ± 6 years and control group was 42 ± 7 years. The mean systolic Blood pressure of control group was 110 ± 5 mmHg, while in case study group it was 140 ± 10 mmHg. The mean Diastolic blood pressure of control group was 80 ± 5 mmHg, while in case study group it was 105 ± 5 mmHg. The mean serum calcium level in control group was 9.82 ± 0.68 mg/dl and in case study group it was 8.45 ± 0.47 mg/dl. There was significant (p <0.05) difference of serum calcium level was observed in case study group (hypertensive subjects group). Conclusion: This study concluded that disturbance in intracellular calcium levels can be one of contributory factor in the pathogenesis of essential hypertension. Keywords: Essential Hypertension, Serum Calcium, Intracellular Calcium, Blood Pressure.

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“Feeling the Blues”: A Case of Calcium Channel Blocker Overdose Managed With Methylene Blue

Cited by 2 publications

References 26 publications

Vasoplegic shock due to amlodipine and losartan poisoning

Vasoplegic shock due to amlodipine and losartan poisoning

Estimation of Serum Calcium Level in the Patients of Hypertension

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