Feinnadelzytologie von Schilddrüsenknoten: Molekulare Diagnostik in der klinischen Routine

Eszlinger, Markus; Neustadt, M; Ruschenburg, I; Neumann, A; Franzius, Christiane; Adam, Sabine; Bacher, K; Hach, A.; Hammoser, R; C, Langvogt; Molwitz, Thomas; Paschke, Ralf

doi:10.1055/s-0034-1369883

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Of these mutations, 92% were of BRAF and 8% were of NRAS. These data are in agreement with findings that BRAF is the most common gene mutation (detected in approximately 50% of sporadic papillary thyroid cancers) [ 24 , 25 ] and NRAS mutations (found with a frequency of 6% by Fukushima et al) [ 22 ] are the most prevalently identified additional mutations [ 21 , 22 , 24 – 26 ]. RET/PTC rearrangement, BRAF, NRAS, and KRAS mutations are considered to be mutually exclusive in papillary thyroid carcinoma [ 23 , 24 ].…”

Section: Discussionsupporting

confidence: 92%

Clinicopathological characteristics of thyroid cancer in the federal state of Salzburg

Rendl

Rodrigues

Schweighofer-Zwink

et al. 2017

Wien Klin Wochenschr

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SummaryObjectiveThe aim of our investigation was to evaluate the clinicopathological characteristics and mutation patterns in newly diagnosed cases of thyroid cancer in the federal state of Salzburg, Austria, in the year 2013.MethodsThe medical records of all patients newly diagnosed with thyroid cancer in 2013 in the federal state of Salzburg were retrospectively reviewed. The clinicopathological characteristics and mutations of thyroid cancers were analyzed.Results63 patients (mean age: 51.0 years, range: 21–81 years; female 75%, male 25%) were identified. 53 patients had papillary (12 follicular variant), 4 patients follicular (1 oxyphilic variant), 3 patients medullary, and 3 patients anaplastic thyroid cancer. T1 tumors were found in 34 patients (pT1a, 20 patients; pT1b, 14 patients), T2 tumors in 10 patients, T3 tumors in 16 patients, and T4 tumors in 3 patients. Lymph node involvement was seen in 15 patients and metastatic disease in 1 patient. Mutations of BRAF (B-type Raf kinase) were detected in 23 and mutation of NRAS (Neuroblastoma RAS Viral Oncogene Homolog) in 2 papillary thyroid cancers. No concomitant mutations of BRAF and NRAS were found.ConclusionFemales accounted for 75% of the patients with newly diagnosed thyroid cancer and the incidence peaked at a younger age than in males. Papillary thyroid cancer was the most frequent tumor type, accounting for 84% of the cases. A high frequency of T1 tumors and cancers with no lymph node involvement was found. Males had a higher proportion of large tumors and more aggressive forms of thyroid cancer than females. Mutations (mostly of BRAF) were found in 47% of the cases. Neither mutations of KRAS (Kirsten rat sarcoma viral oncogene homologue) nor concomitant mutations of BRAF and NRAS were found.

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Section: Discussionsupporting

confidence: 92%

Clinicopathological characteristics of thyroid cancer in the federal state of Salzburg

Rendl

Rodrigues

Schweighofer-Zwink

et al. 2017

Wien Klin Wochenschr

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Molecular Testing of Thyroid Fine-Needle Aspirations Improves Presurgical Diagnosis and Supports the Histologic Identification of Minimally Invasive Follicular Thyroid Carcinomas

Eszlinger

Piana

Moll

et al. 2015

Thyroid

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Molecular testing of air-dried FNA samples improves presurgical diagnosis. Discrepant sensitivities and specificities reported previously are most likely related to the use of different grading schemes resulting in different compositions of the cytologic categories, interobserver variability to diagnose follicular variant of papillary thyroid carcinomas and a different prevalence of RAS mutations in follicular carcinomas. The knowledge of the molecular testing might support the histologic identification of minimally invasive follicular carcinomas.

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Evaluation of a Two-Year Routine Application of Molecular Testing of Thyroid Fine-Needle Aspirations Using a Seven-Gene Panel in a Primary Referral Setting in Germany

Eszlinger

BöhmeKatharina

UllmannMaha

et al. 2017

Thyroid

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In conclusion, the data suggest that the application of the current seven-gene panel in a routine primary referral setting does not improve the presurgical diagnosis of thyroid FNAs. While the diagnostic relevance of RAS mutations in thyroid tumors needs further investigation, more comprehensive mutation panels with more cancer-specific mutations may improve the presurgical diagnosis of thyroid FNAs.

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Feinnadelzytologie von Schilddrüsenknoten: Molekulare Diagnostik in der klinischen Routine

Abstract: These results demonstrate that rearrangements and point mutations can be detected in routinely obtained air-dried FNAC samples.

Cited by 3 publications

References 17 publications

Clinicopathological characteristics of thyroid cancer in the federal state of Salzburg

Clinicopathological characteristics of thyroid cancer in the federal state of Salzburg

Molecular Testing of Thyroid Fine-Needle Aspirations Improves Presurgical Diagnosis and Supports the Histologic Identification of Minimally Invasive Follicular Thyroid Carcinomas

Evaluation of a Two-Year Routine Application of Molecular Testing of Thyroid Fine-Needle Aspirations Using a Seven-Gene Panel in a Primary Referral Setting in Germany

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