FELASA recommendations for the health monitoring of mouse, rat, hamster, gerbil, guineapig and rabbit experimental units: Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management, November 1995

Rehbinder, Claes; Baneux, P.; Forbes, Derek; Herck, H. van; Nicklas, Werner; Rugaya, Z.; Winkler, G.

doi:10.1258/002367796780684881

Cited by 126 publications

(34 citation statements)

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“…According to the routinely monitored health status of both rats and mice, following Federation of European Laboratory Animal Science Associations (FELASA) guidelines (Rehbinder et al, 1996), there was no risk of disease transmission between the two species. The day the rats were introduced into the mouse room is referred to as Day 0.…”

Section: Methodsmentioning

confidence: 99%

There's a Rat in My Room! Now What? Mice Show No Chronic Physiological Response to the Presence of Rats

Meijer

Loo

Baumans

2009

Journal of Applied Animal Welfare Science

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In general, guidelines on housing and care of animals in the laboratory state that rats and mice should not be housed in the same room. Mice may perceive rats as predators. Although one theory says this can cause stress, there is little scientific evidence to support this theory. In the wild, rats and mice usually do not share the same microhabitat, but this appears to be true for most small rodent species. Furthermore, reports of predatory behavior of rats toward mice mainly originate from experimental settings using rats with high inbred levels of aggression. This experiment measured heart rate (HR), body temperature (BT), activity (AC), and urinary corticosterone in female C57BL/6 mice before, during, and after introducing Wistar rats into their room. The study found no chronic effects of rat introduction on any parameters. The study concluded that housing rats and mice in the same room is at least less disturbing than cage cleaning, which caused a temporary increase of HR, BT, and AC. Current results do not support legislation based on compromised welfare.

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Section: Methodsmentioning

confidence: 99%

There's a Rat in My Room! Now What? Mice Show No Chronic Physiological Response to the Presence of Rats

Meijer

Loo

Baumans

2009

Journal of Applied Animal Welfare Science

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“…Only male offspring were used for the present study. Animals were microbiologically monitored according to Federation of European Laboratory Animal Science Association recommendations (11). All research and animal care procedures were approved by the Government of Lower Saxony (Hannover, Germany), and performed in compliance with international animal welfare standards.…”

Section: Animals and Selection Of Rat Strainmentioning

confidence: 99%

Postnatal Life Events Affect the Severity of Asthmatic Airway Inflammation in the Adult Rat

Kruschinski

Skripuletz

Bedoui

et al. 2008

The Journal of Immunology

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Genetic and hygienic factors influence susceptibility to asthma. In autoimmune and inflammatory diseases, additional effects of the psychosocial environment have been demonstrated that might also play a role in asthma. In this study, the impact of different early postnatal stressors on an OVA-induced model of asthma was tested in adulthood. Fischer 344 rats were subjected to either repeated handling stimulation (HA), maternal separation (MS), or were left undisturbed in their first 4 wk of life. Behavioral differences were characterized at the age of 4 mo. At 5 mo of age, immunological cellular and serologic changes were investigated and experimental asthma was induced. Results show significantly increased exploratory behavior and reduced anxiety in HA rats compared with MS and controls. Without further behavioral or immunological challenges, HA animals exhibited an increased ex vivo NK cell cytotoxicity but no other obvious immunological differences. After induction of asthma, in contrast, MS animals exhibited proinflammatory effects in leukocyte subset composition including increased eosinophil numbers, whereas levels of IgE and the allergy-specific cytokine IL-13 were reduced compared with HA. There was a most remarkable increase of adrenocorticotropin in HA animals, comparing pre- to postchallenge plasma levels. These data demonstrate for the first time that early postnatal stimulative or adverse experiences exert long-lasting changes of the “neuroendocrinoimmune” interface in adulthood, resulting in either protective or aggravating mechanisms in allergic airway disease. Thus, in addition to genetic and hygienic factors, nongenetically acquired individual differences contribute to the pathobiology of asthma.

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“…Rats were bred and kept under specific pathogen-free conditions. Sanitary controls were performed every 3-4 mo according to the health-monitoring program of the Federation of European Laboratory Animal Science Associations (15).…”

Section: Housing Conditions Of Ratsmentioning

confidence: 99%

Studies of Congenic Lines in the Brown Norway Rat Model of Th2-Mediated Immunopathological Disorders Show That the Aurothiopropanol Sulfonate-Induced Immunological Disorder (Aiid3) Locus on Chromosome 9 Plays a Major Role Compared toAiid2on Chromosome 10

Mas

Cavaillès

Colacios

et al. 2004

The Journal of Immunology

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Brown Norway (BN) rats treated with aurothiopropanol-sulfonate (Atps) constitute a model of Th2-mediated immunological disorders associated with elevated IgE responses and renal IgG deposits. Using F2 offspring between Atps-susceptible BN and Atps-resistant Lewis rats, we had previously mapped three quantitative trait loci on chromosomes 9, 10, and 20 for which BN alleles increased susceptibility to Atps-induced immunological disorders (Aiid). In this study we have used congenic lines for the latter two quantitative trait loci, formerly called Atps2 and Atps3 and now named Aiid2 (chromosome 10) and Aiid3 (chromosome 9), for fine mapping and characterization of their impact on Atps-triggered reactions. In Aiid2 congenic lines, the gene(s) controlling part of the IgE response to Atps was mapped to an ∼7-cM region, which includes the IL-4 cytokine gene cluster. Two congenic lines in which the introgressed segments shared only a portion of this 7-cM region, showed an intermediate IgE response, indicating the involvement of several genes within this region. Results from BN rats congenic for the Lewis Aiid3 locus, which we mapped to a 1.2-cM interval, showed a stronger effect of this region. In this congenic line, the Atps-triggered IgE response was 10-fold lower than in the BN parental strain, and glomerular IgG deposits were either absent or dramatically reduced. Further genetic and functional dissections of these loci should provide insights into pathways that lead to Th2-adverse reactions.

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FELASA recommendations for the health monitoring of mouse, rat, hamster, gerbil, guineapig and rabbit experimental units: Report of the Federation of European Laboratory Animal Science Associations (FELASA) Working Group on Animal Health accepted by the FELASA Board of Management, November 1995

Cited by 126 publications

References 0 publications

There's a Rat in My Room! Now What? Mice Show No Chronic Physiological Response to the Presence of Rats

There's a Rat in My Room! Now What? Mice Show No Chronic Physiological Response to the Presence of Rats

Postnatal Life Events Affect the Severity of Asthmatic Airway Inflammation in the Adult Rat

Studies of Congenic Lines in the Brown Norway Rat Model of Th2-Mediated Immunopathological Disorders Show That the Aurothiopropanol Sulfonate-Induced Immunological Disorder (Aiid3) Locus on Chromosome 9 Plays a Major Role Compared toAiid2on Chromosome 10

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