Feline calicivirus infection in cats with virulent systemic disease, Italy

Caringella, Francesca; Elia, Gabriella; Decaro, Nicola; Martella, Vito; Lanave, Gianvito; Varello, Katia; Catella, Cristiana; Diakoudi, Georgia; Carelli, Grazia; Colaianni, Maria Loredana; Bò, Stefano; Buonavoglia, Canio

doi:10.1016/j.rvsc.2019.02.008

Cited by 41 publications

(51 citation statements)

References 24 publications

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“…As a consequence, only the detection of a CCoV-IIa strain in extraintestinal tissues accounts for a possible pCCoV infection in dogs. This situation is similar to that observed in calicivirus infections in cats, where markers of pathogenicity have been not yet detected in highly virulent strains, so that diagnosis of systemic calicivirosis is obtained when the virus is detected in extrarespiratory tissues (Caringella et al, 2019).…”

Section: Discussionsupporting

confidence: 69%

Circulation of pantropic canine coronavirus in autochthonous and imported dogs, Italy

Alfano

Fusco

Mari

et al. 2020

Transbound Emerg Dis

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Canine coronavirus (CCoV) strains with the ability to spread to internal organs, also known as pantropic CCoVs (pCCoVs), have been detected in domestic dogs and wild carnivores. Our study focused on the detection and molecular characterization of pCCoV strains circulating in Italy during the period 2014–2017 in autochthonous dogs, in dogs imported from eastern Europe or illegally imported from an unknown country. Samples from the gut and internal organs of 352 dogs were screened for CCoV; putative pCCoV strains, belonging to subtype CCoV‐IIa, were identified in the internal organs of 35 of the examined dogs. Fifteen pCCoV strains were subjected to sequence and phylogenetic analyses, showing that three strains (98960‐1/2016, 98960‐3/2016, 98960‐4/2016) did not cluster either with Italian or European CCoVs, being more closely related to alphacoronaviruses circulating in Asia with which they displayed a 94%–96% nucleotide identity in partial spike protein gene sequences. The pCCoV‐positive samples were also tested for other canine viruses, showing co‐infections mainly with canine parvovirus.

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Section: Discussionsupporting

confidence: 69%

Circulation of pantropic canine coronavirus in autochthonous and imported dogs, Italy

Alfano

Fusco

Mari

et al. 2020

Transbound Emerg Dis

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“…A alta variabilidade pode contribuir ainda para a formação de cepas hipervirulentas e interferir no desenvolvimento de imunidade que confira proteção contra uma ampla variedade de cepas (RADFORD et al, 2007). Nenhuma relação entre características genéticas e a enfermidade sistêmica pôde ser definida, e a cada novo relato, diferentes cepas parecem estar envolvidas (CARINGELLA et al, 2019;PRIKHODKO et al, 2014). Curiosamente, foi relatado a presença de cepas de VS-FCV infectando o núcleo de células acometidas, embora, assim como outros vírus de genoma RNA, a infecção seja normalmente restrita ao citoplasma celular, local onde realizam seu ciclo replicativo (PESAVENTO et al, 2008 COYNE et al, 2012;RADFORD et al, 2007).…”

Section: Etiologiaunclassified

“…O FCV tem distribuição mundial, e a forma sistêmica da enfermidade já foi descrita tanto em felinos domésticos quanto selvagens (HARRISON et al, 2007). O primeiro relato de VS-FCV surgiu em 2000, no estado da Califórnia, USA (PEDERSEN et al, 2000), seguido de relatos subsequentes no mesmo país (ABD-ELDAIM et al, 2005;HURLEY et al, 2004;SCHORR-EVANS et al, 2003), e com posteriores descrições na Europa (BATTILANI et al, 2013;CARINGELLA et al, 2019;COYNE et al, 2006a;DESCHAMPS et al, 2015;MEYER et al, 2011;REYNOLDS et al, 2009;WILLI et al, 2016) e na Ásia (GUO et al, 2018). No Brasil, não existem relatos descritos de VS-FCV, embora infecções pelo FCV tenham sido demonstradas em animais domésticos e selvagens, tanto em estudos sorológicos quanto por técnicas moleculares (CASTRO et al, 2015;FILONI et al, 2006;FILONI et al, 2012;FURTADO et al, 2017;HENZEL et al, 2012;HENZEL et al, 2013;JOHANN et al, 2009;LARA et al, 2017;PEREIRA et al, 2018;BATISTA et al, 2005).…”

Section: Epidemiologiaunclassified

“…Nos últimos anos, uma forma mais grave da doença vem sendo descrita em diferentes países da América do Norte (ABD-ELDAIM et al, 2005;HURLEY et al, 2004;PEDERSEN et al, 2000;SCHORR-EVANS et al, 2003), Europa (BATTILANI et al, 2013;CARINGELLA et al, 2019;COYNE et al, 2006a;DESCHAMPS et al, 2015;MEYER et al, 2011;REYNOLDS et al, 2009;WILLI et al, 2016) e Ásia (GUO et al, 2018). Nestes relatos, houve o isolamento de cepas de FCV altamente virulentas, as quais foram denominadas de calicivírus virulento associados à doença sistêmica (Virulent Systemic Feline Calicivírus, VS-FCV).…”

Section: Introductionunclassified

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Calicivirose Sistêmica: Uma Enfermidade Emergente Associada Ao Calicivírus Felino

Becker¹,

Monteiro²,

Costa³

et al. 2020

SCI. ANIM. HEALTH

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O calicivírus felino está distribuído mundialmente na população de gatos domésticos, estando geralmente associado a um complexo de doenças que afetam o sistema respiratório e cavidade oral, e incluem conjuntivite, rinosinusite, lacrimejamento, ulceração na mucosa oral e gengivite. Embora ainda não descrito no Brasil, nas últimas décadas alguns países têm relatado surtos envolvendo cepas de calicivírus denominadas de Calicivírus Virulento Sistêmico (Virulent Systemic Feline Calicivirus, VS-FCV) causando uma enfermidade nova, denominada de Calicivirose Sistêmica. Tal desordem clínica tem um mecanismo complexo e ainda pouco compreendido, que parece afetar mais gravemente gatos adultos e vacinados, resultando em altas taxas de mortalidade. Neste sentido, tanto a enfermidade como o seu agente etiológico vêm se tornando uma preocupação cada vez maior na medicina veterinária. Esta revisão acerca da Calicivirose Sistêmica aborda as características das cepas virais envolvidas, bem como sinais clínicos, métodos de diagnóstico, e possíveis alternativas de tratamento e prevenção.

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“…FCV vaccines have been commercially available for 30 years but FCV remains highly prevalent among cats, and none of the vaccines currently on sale can protect cats from all strains of FCV (Sato et al, 2017). In the past decade, severe systemic diseases caused by VS-FCV have been reported in many countries (Caringella et al, 2019;Guo et al, 2018;Radford and Gaskell, 2011;Schulz et al, 2011). One reason for the incomplete protection afforded by vaccines may be that the broad spectrum of genetic and antigenic variability of FCV results in different strains with little cross-reactivity (Bergmann et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro

Cui

Xie

et al. 2020

Antiviral Research

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Feline calicivirus (FCV) is a highly contagious pathogen that causes acute upper respiratory infections and oral disease in cats, thus seriously endangering feline health. Recently, there have been outbreaks of particularly virulent variant strains of FCV, which can cause both acute symptoms and fatal systemic disease. The discovery of effective antiviral agents to treat FCV infection is, therefore, gradually assuming increased importance. In this study, we showed that both nitazoxanide and mizoribine had antiviral activity in F81 cells infected with different strains of FCV and also demonstrated a synergistic effect between the two drugs. Experiments in cats challenged with FCV showed that nitazoxanide significantly reduced the clinical symptoms of FCV infection, reduced viral load in the trachea and lungs, and reduced viral shedding. Our results showed that nitazoxanide and mizoribine could potentially be used as therapeutic agents to treat FCV infection.

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Feline calicivirus infection in cats with virulent systemic disease, Italy

Cited by 41 publications

References 24 publications

Circulation of pantropic canine coronavirus in autochthonous and imported dogs, Italy

Circulation of pantropic canine coronavirus in autochthonous and imported dogs, Italy

Calicivirose Sistêmica: Uma Enfermidade Emergente Associada Ao Calicivírus Felino

Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro

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