Feline discrete high‐grade gastrointestinal lymphoma treated with surgical resection and adjuvantCHOP‐based chemotherapy: retrospective study of 20 cases

Abstract

The aim of this retrospective study was to evaluate the outcome of cats treated with surgical intervention for a discrete intermediate-/high-grade gastrointestinal lymphoma prior to CHOP-based chemotherapy. Variables including sex, breed, haematocrit, white blood cell count, serum albumin concentration, clinical stage of disease, gastrointestinal obstruction and peritonitis were assessed for their effect on survival. Twenty cats met the inclusion criteria with three cats still alive at the time of data analysis. The overall median survival time (MST) was 417 days (range: 12-2962 days). The disease-free interval (DFI) was 357 days (range: 0-1585 days) with six cats still deemed in remission prior to death. Only clinical stage had a significant effect on both MST and DFI. Cats with discrete intermediate/high-grade gastrointestinal lymphoma that undergo surgical resection followed by adjuvant CHOP chemotherapy may achieve acceptable overall survival times.

Outcomes in 40 cats with discrete intermediate‐ or large‐cell gastrointestinal lymphoma masses treated with surgical mass resection (2005‐2015)

“…The overall survival times in this study are comparable to those reported for cats with GI LSA treated with systemic chemotherapy alone . In addition to improving survival time, maintaining quality of life is an important goal in LSA case management because treatment is often palliative in nature.…”

“…Unlike in dogs, in which multicentric LSA predominates and is overwhelmingly responsive to chemotherapy, the response to multiagent chemotherapy in cats with feline GI large‐cell LSA is less predictable, with overall response rates ranging from 30% to 75% . Response durability also tends to be less favorable, with reported median survival times (MST) of 3 to 6 months . However, MST tends to be closely linked to response to chemotherapy.…”

“…Because of these strict criteria, many cats in which GI LSA has been newly diagnosed cannot be easily compared with this study population because extra‐GI disease at diagnosis is common, and specialty‐level medicine is not attainable for some owners. In addition, all cats in the Gouldin et al study were required to survive the surgical procedure, precluding conclusions regarding the incidence of mortality attributed to the surgical procedures. Obtaining information regarding postoperative outcomes in cats that do not meet this narrow inclusion criteria is of interest in guiding treatment decisions in the rest of the GI LSA cat population.…”

Evaluation of the extent of neoplastic infiltration in small intestinal tumours in dogs

“…A recent veterinary publication supports the combination of surgery and chemotherapy to treat feline intestinal lymphoma (Gouldin et al . ). This treatment combination has also been shown to improve overall survival of people treated for intestinal lymphoma (Kim et al .…”

“…Lymphoma is usually treated with chemotherapy unless there is perforation, the need for a biopsy or intestinal obstruction (Culp et al 2012;Selting 2013). There is, however, growing evidence in both veterinary and human literature supporting the combination of surgery with chemotherapy to treat discrete intestinal lymphoma (Kim et al 2011;Gou et al 2012;Gouldin et al 2017;Hong et al 2017).…”