Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats

Taylor, Samantha; Goodfellow, M; Browne, William J.; Walding, B R; Murphy, Suzanne; Tzannes, Sophia; Gerou-Ferriani, Magda; Schwartz, A; Dobson, J. M.

doi:10.1111/j.1748-5827.2009.00813.x

Cited by 123 publications

(173 citation statements)

References 23 publications

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“…By contrast, none of the 3 animals in the present study with intraocular lymphoma for which bone marrow aspirate samples were Additionally, other than mild normocytic, normochromic anemia in 1 dog (Hct, 37.6%; reference range, 40% to 55%), no evidence of anemia or thrombocytopenia was detected for any animals in the present study. Determination of primary anatomic location, 19,20 stage, [21][22][23][24][25] and substage 23,24,26 may be important for determination of a prognosis for dogs and cats with lymphoid neoplasia, but this has not been consistently proven, as results of other studies [40][41][42][43][44] indicate that these factors are not significantly correlated with prognosis. Established guidelines for staging of lymphoid neoplasia in domestic animals 27 suggest that involvement of a single lymph node or lymphoid tissue in a single organ represents stage 1 disease, whereas involvement of blood, bone marrow, or organs other than the liver and spleen represents stage 5 disease.…”

Section: Discussionmentioning

confidence: 52%

“…Primary anatomic location, 19,20 anatomic distribution (stage), [21][22][23][24][25] and presence or absence of clinical signs (substage) 23,24,26 may be prognostic factors for dogs and cats with lymphoid neoplasia. However, application of World Health Organization tumor staging guidelines 27 is problematic for animals with PSOL and further investigation is warranted.…”

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confidence: 99%

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Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL). Design—Retrospective case series. Animals—7 dogs and 2 cats with PSOL. Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined. Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

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Section: Discussionmentioning

confidence: 52%

mentioning

confidence: 99%

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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“…32 However, adenocarcinoma is the most common primary renal tumor found. 33 Other tumors that have been identified less frequently include transitional cell carcinoma, nephroblastoma, hemangiosarcoma and adenoma.…”

Section: Neoplastic Nephropathymentioning

confidence: 99%

Feline acute kidney injury

Monaghan

Nolan²,

Labato

2012

Journal of Feline Medicine and Surgery

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Practical relevance: Acute kidney injury (AKI) is a frequently recognized disease process in cats that requires immediate and aggressive intervention. A thorough understanding of the pathophysiologic processes underlying AKI and familiarity with the most common etiologies are essential for providing the most effective and timely therapy. Possessing this knowledge will also allow a more accurate prognosis to be given, and afford the best chance of a favorable outcome. Clinical challenges:Feline patients often present with vague signs of AKI, which may delay treatment and adversely affect the prognosis. Their response to injury and treatment is often different to that of other species.Audience: This two-part review article is directed at small animal practitioners as well as specialists. Part 1 reviews mechanisms underlying AKI in the cat, as well as etiologies and treatments related to some specific causes of AKI. New terminology -and a new emphasisAcute kidney injury (AKI) is a relatively new term in the nephrology literature that largely replaces the use of 'acute renal failure' (ARF). Originally introduced in the human literature, AKI allows for greater stratification of cases with regard to severity and prognosis. By suggesting that a patient has injury, rather than failure, one can recognize the potential for earlier treatment and recovery. In human medicine, the older term 'ARF' refers only to patients requiring renal replacement therapy (RRT). Additionally, the more common term 'kidney', rather than 'renal', facilitates communication with and understanding by clients of AKI. The incidence of AKI in cats is not known, but it is not uncommon and can be caused by a variety of different insults. A uniform definition for AKI does not exist in the veterinary literature and varies among publications. Generally accepted criteria include an abrupt reduction in kidney function resulting in alterations in glomerular filtration, urine production and tubular function. These alterations result in an inability to maintain fluid, electrolyte and acid-base balance, and may lead to azotemia. PathophysiologyThe pathophysiology of AKI is complex, but can be described by four stages: initiation, extension, maintenance and recovery.

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“…6 Clinical response to treatment, feline leukaemia virus (FeLV) status, location and clinical stage remain the only consistent prognostic factors in cats. 4,5,7 Given the paucity of information on prognosis, a marker to assist in the diagnosis and prognosis of this disease would be clinically useful.…”

Section: Introductionmentioning

confidence: 99%

“…1 Multiple lymphoma anatomical locations have been described and a variety of chemotherapeutic protocols used in the management of this disease. [2][3][4] Diagnosis is generally achieved via cytology or histopathology. Reliable prognostic indicators or diagnostic markers seem elusive in this species.…”

Section: Introductionmentioning

confidence: 99%

Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

Taylor

Dodkin

Papasouliotis

et al. 2012

Journal of Feline Medicine and Surgery

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The thymidine kinases are enzymes that convert deoxythymidine to deoxythymidine monophosphate and have a function in DNA synthesis. Rapidly proliferating cells will have higher levels of thymidine kinase. Serum thymidine kinase activity (sTK) is a useful tumour marker in humans and dogs, with utility as a prognostic indicator in lymphoma. In the current study serum samples were collected from 49 clinically healthy cats, 33 with lymphoma, 55 with inflammatory disease and 34 with non-haematopoietic neoplasia (NHPN). sTK was measured using a radioenzyme assay and a reference interval (1.96 × SD) was established from the clinically healthy cats (<5.5 U/l). Mean sTK activity for healthy cats was 2.2 U/l (range 0.8-8.4, ± SD 1.7). Mean sTK activity for cats with lymphoma was 17.5 U/l (range 1.0-100.0 SD ± 27.4). Mean sTK activity for cats with NHPN was 4.2 U/l (range 1.0-45.0, SD ± 8.6). Mean sTK activity for the inflammatory group was 3.4 U/l (range 1.0-19.6, SD 3.9). Cats with lymphoma had significantly higher sTK activity than healthy cats or cats with inflammatory disease (P <0.0001) and cats with NHPN (P <0.0002). sTK activity is a potentially useful biomarker for feline lymphoma and further study is required to assess its utility as a prognostic indicator.

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Feline extranodal lymphoma: response to chemotherapy and survival in 110 cats

Abstract: Cats with extranodal lymphoma respond to chemotherapy and achieve survival times comparable to other locations. Corticosteroid pretreatment reduced survival time in cats achieving complete remission.

Cited by 123 publications

References 23 publications

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Feline acute kidney injury

Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma

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