Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors

Abstract

The expectation that cell-mediated immunity is important in the control of feline leukemia virus (FeLV

Adjuvant Effect of the Propionibacterium acnes and Its Purified Soluble Polysaccharide on the Immunization with Plasmidial DNA Containing a Trypanosoma cruzi Gene

“…The majority of recent data describes adjuvant effects that modulate or potentialize the Th1 immune response pattern (11,21,24,25,37). In most of these studies cytokines or plasmids encoding cytokine genes to amplify this kind of immune response are used.…”

“…Some studies demonstrated that co-administration of plasmids encoding cytokine genes as adjuvants significantly enhanced immune response. In another study the co-administration of feline leukemia virus DNA vaccine with IL-12 and IL-18 expression vectors improved vaccine efficacy (11).…”

“…The association of specific adjuvants and DNA vaccination has been extensively investigated (11,21,25,37). Some studies demonstrated that co-administration of plasmids encoding cytokine genes as adjuvants significantly enhanced immune response.…”

Vaccine-Induced Immunity againstHelicobacter pyloriInfection Is Impaired in IL-18-Deficient Mice

“…For example, IL-18 was reported to play a major role in resistance against Yersinia, mycobacterial, cryptococcal, Salmonella, Leishmania, herpes simplex virus type 1, feline leukemia virus, and vaccinia virus infections (51)(52)(53)(54)(55)(56)(57)(58). Similar to H. pylori, these infectious agents elicit Th1-dominated immune responses (51,52,55,57,59). Given that IL-18 primarily is involved in protection as a coregulator of Th1 development together with IL-12, it is not surprising that we found a strong dependence on IL-18 for the development of host resistance also against H. pylori infection.…”

Vírus da leucemia felina: análise da classificação da infecção, das técnicas de diagnóstico e da eficácia da vacinação com o emprego de técnicas sensíveis de detecção viral

“…O objetivo principal era estabelecer um modelo animal para as pesquisas com outros retrovírus, em destaque, o Vírus da imunodeficiência humana (HIV) (HANLON et al, 2001). Diversas vacinas em diferentes formatos foram desenvolvidas, mas comparar os resultados de eficácia sempre foi motivo de discussão, principalmente, pelo emprego de diferentes vias de inoculação, cepas virais e amostragens (SPARKES, 1997;LUTZ et al, 2009 (LUTZ et al, 2009), nenhuma vacina promove 100% de proteção e não previne a infecção, no entanto, a vacinação previne o desenvolvimento de antigenemia persistente.…”