Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil

Cristo, Thierry Grima de; Biezus, Giovana; Noronha, Laura Formighieri de; Pereira, L. H.; Withoeft, Jéssica Aline; Furlan, Leticia Vitoria; Costa, Leonardo Silva da; Traverso, Sandra Davi; Casagrande, Renata Assis

doi:10.1016/j.jcpa.2018.10.171

Cited by 27 publications

(25 citation statements)

References 23 publications

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“…Similarly to the present study, a necropsy‐based study conducted in the state of Santa Catarina found that over 50% of cats with lymphoma presented neoplastic positive FeLV immunolabelling, indicating high prevalence of this retroviral infection in this population . The high detection of FeLV infection, along with the representative number of cases of mediastinal lymphoma points out that viral agents still play an important role in feline lymphoma in Brazil.…”

Section: Discussionsupporting

confidence: 83%

Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil

Leite-Filho

Panziera

Bandinelli

et al. 2019

Vet Comparative Oncology

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A retrospective study compiling cases of feline lymphoma diagnosed during 12 years (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) in Southern Brazil was performed. A total of 125 cases of lymphoma diagnosed in cats were reviewed, and information including age, breed, sex and tumour topography were collected. FeLV and FIV immunohistochemical tests were performed, as well as immunophenotyping of lymphomas. The alimentary form represented the most common presentation (42/125), followed by mediastinal lymphoma (35/125). Out of 125 cases, 79 presented positive retroviral immunostaining in tumour tissue (52 FeLV alone, 14 FIV alone and 13 presented FIV and FeLV co-infections), 66/125 of the cases were of T-cell origin and 59/125 of the cases were of Bcell origin. The median age of cats with T-cell lymphoma was 120 months (10-240 months), and 60 months (6-204 months) for cats with B-cell lymphoma. The most frequent alimentary tumour presentation was the enteropathy-associated T-cell lymphoma (type 1), and the major type of mediastinal tumour observed was diffuse large B-cell lymphoma. Considering only mediastinal and alimentary lymphomas (n = 77), the prevalence of mediastinal lymphoma in FeLV-positive cats was 2.21 times higher than the prevalence of this type of tumour in FeLV-negative cats (P = .036).Mediastinal lymphoma was more frequently observed in younger cats, and the prevalence of mediastinal tumours in these animals was 3.06 times higher than the prevalence of this tumour form in old cats (P = .0125). The present study indicates that retroviral infections still play an important role in the development of feline lymphomas in southern Brazil.

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Section: Discussionsupporting

confidence: 83%

Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil

Leite-Filho

Panziera

Bandinelli

et al. 2019

Vet Comparative Oncology

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“…Most of the cats of the present study had T‐cell phenotype lymphomas (67%), although the literature presents conflicting results with regard to the neoplastic lymphocyte phenotypes in FeLV‐associated lymphomas 16,28‐30 . Although recent studies have shown a decrease in lymphomas associated with FeLV, due to efficient vaccination protocols targeting this virus, 29 other studies conducted in Brazil through serological, molecular, and immunohistochemical analyses have established a higher prevalence of FeLV associated with lymphomas 31‐34 …”

Section: Discussionmentioning

confidence: 54%

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

Bandinelli

Bianchi

Wronski

et al. 2020

Veterinary Ophthalmology

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Objective To characterize the frequency and distribution of secondary ocular neoplasms in dogs and cats identified during necropsy. Methods A retrospective analysis of necropsy records of dogs and cats was conducted, and cases with metastatic/multicentric neoplasms with an extraocular origin, involving the eyes, were selected. Results From January 2015 to January 2019, we identified a total of 233 dogs and 100 cats with metastatic disease. Of these, 11.6% (27/233) of the dogs and 13% (13/100) of the cats had ocular metastases. Lymphoma was the most common multicentric neoplasm involving the eyes of both species. In dogs, these neoplasms occurred bilaterally, predominantly in the anterior uvea, and were diffuse large B‐cell, T‐lymphoblastic, peripheral T‐cell not otherwise specified, and lymphocytic B‐cell lymphomas. In cats, feline leukemia virus (FeLV)‐associated T‐cell lymphoma was the most common. Mammary carcinoma was the second most common ocular metastatic neoplasm in bitches, with a predominantly unilateral involvement of the uveal tract. In cats, following lymphoma, pulmonary and squamous cell carcinomas were the most common multicentric/metastatic neoplasms of the eyes. Individual cases of cholangiocarcinoma, hemangiosarcoma, and chemodectoma in dogs, as well as mammary gland cribriform carcinoma, salivary gland carcinoma, and histiocytic sarcoma in cats were detected. Conclusions The eyes of dogs were mostly affected by lymphoma or mammary gland carcinoma, while those of cats mostly had lymphoma, pulmonary carcinoma, or squamous cell carcinoma as the main metastatic/multicentric neoplasm. To the best of our knowledge, this is the first study to identify intraocular metastatic cholangiocarcinoma and chemodectoma in dogs, aside from identifying salivary gland carcinoma in cats.

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“…To differentiate between these outcomes, antigen testing (to detect viral capsid protein p27), polymerase chain reaction (PCR) testing (to detect proviral DNA), reverse-transcription (RT)-PCR testing (to detect viral RNA [vRNA]), and testing for antibodies against FeLV are required [16]. Progressively-infected cats have the poorest prognosis, with reported mortality rates of up to 90% within three years of infection, predominantly due to aplastic anaemia, lymphoma, leukaemia, or other myeloproliferative diseases [2,15,16,19,20]. Although the role of regressive FeLV infection in disease causation is not clear, an association between regressive infections and lymphoma has been observed in Australia and Canada [21,22,23].…”

Section: Introductionmentioning

confidence: 99%

The Diagnosis of Feline Leukaemia Virus (FeLV) Infection in Owned and Group-Housed Rescue Cats in Australia

Westman

Norris

Malík

et al. 2019

Viruses

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A field study was undertaken to (i) measure the prevalence of feline leukaemia virus (FeLV) exposure and FeLV infection in a cross-section of healthy Australian pet cats; and (ii) investigate the outcomes following natural FeLV exposure in two Australian rescue facilities. Group 1 (n = 440) consisted of healthy client-owned cats with outdoor access, predominantly from eastern Australia. Groups 2 (n = 38) and 3 (n = 51) consisted of a mixture of healthy and sick cats, group-housed in two separate rescue facilities in Sydney, Australia, tested following identification of index cases of FeLV infection in cats sourced from these facilities. Diagnostic testing for FeLV exposure/infection included p27 antigen testing using three different point-of-care FeLV kits and a laboratory-based ELISA, real-time polymerase chain reaction (qPCR) testing to detect FeLV proviral DNA in leukocytes, real-time reverse-transcription PCR (qRT-PCR) testing to detect FeLV RNA in plasma, and neutralising antibody (NAb) testing. Cats were classified as FeLV-uninfected (FeLV-unexposed and presumptively FeLV-abortive infections) or FeLV-infected (presumptively regressive and presumptively progressive infections). In Group 1, 370 FeLV-unexposed cats (370/440, 84%), 47 abortive infections (47/440, 11%), nine regressive infections (9/440, 2%), and two progressive infections (2/440, 0.5%) were identified, and 12 FeLV-uninfected cats (12/440, 3%) were unclassifiable as FeLV-unexposed or abortive infections due to insufficient samples available for NAb testing. In Groups 2 and 3, 31 FeLV-unexposed cats (31/89, 35%), eight abortive infections (8/89, 9%), 22 regressive infections (22/89; 25%), and 19 progressive infections (19/89; 21%) were discovered, and nine FeLV-uninfected cats (9/89; 10%) were unclassifiable due to insufficient samples available for NAb testing. One of the presumptively progressively-infected cats in Group 3 was likely a focal FeLV infection. Two other presumptively progressively-infected cats in Group 3 may have been classified as regressive infections with repeated testing, highlighting the difficulties associated with FeLV diagnosis when sampling cats at a single time point, even with results from a panel of FeLV tests. These results serve as a reminder to Australian veterinarians that the threat of FeLV to the general pet cat population remains high, thus vigilant FeLV testing, separate housing for FeLV-infected cats, and FeLV vaccination of at-risk cats is important, particularly in group-housed cats in shelters and rescue facilities, where outbreaks of FeLV infection can occur.

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Feline Lymphoma and a High Correlation with Feline Leukaemia Virus Infection in Brazil

Cited by 27 publications

References 23 publications

Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil

Epidemiological, pathological and immunohistochemical aspects of 125 cases of feline lymphoma in Southern Brazil

Ophthalmopathologic characterization of multicentric or metastatic neoplasms with an extraocular origin in dogs and cats

The Diagnosis of Feline Leukaemia Virus (FeLV) Infection in Owned and Group-Housed Rescue Cats in Australia

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