Feline lymphoma: diagnosis, staging and clinical presentations

Mason, Sarah; Pittaway, Charlie

doi:10.1002/inpr.163

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…Lymphoma can arise from lymphoid and non-lymphoid tissues throughout the body and can affect various anatomical locations [ 1 , 2 , 3 , 4 , 5 ]. The classification of lymphoma in cats is complex, with different subtypes identified based on their biological behavior, cell origin, and anatomical location [ 2 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Classification based on anatomical location usually differentiates gastrointestinal or alimentary lymphoma from other extranodal forms (nasopharyngeal, renal, central nervous system, etc. ), and also multicentric (peripheral lymph nodes), mediastinal, and mixed forms [ 2 , 6 , 7 ]. The prevalence of one anatomical form of feline lymphoma versus others is largely influenced by the FeLV status [ 2 , 3 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…With the widespread use of FeLV vaccination, FeLV-induced forms of lymphoma are now less common [ 4 , 7 , 10 ]. This leads to regional variability of anatomical presentations with gastrointestinal lymphoma being the most prevalent in countries with a low FeLV prevalence [ 4 , 12 , 13 , 14 ], and multicentric and mediastinal forms being more common in countries with a higher rate of FeLV infections [ 3 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong

Almendros,

Chan,

dos Santos Horta

et al. 2024

Animals

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This study aimed to characterize and describe the different lymphoma types and anatomical forms in cats in Hong Kong. The clinical and histopathological data of cats diagnosed with lymphoma by cytology and/or histopathology were collected from a large diagnostic laboratory in Hong Kong. In total, 444 cats were diagnosed with lymphoma over four years (2019–2022). Like other countries where there is a low prevalence of FeLV infection, the predominant form of lymphoma was gastrointestinal (abdominal). Nasopharyngeal and peripheral nodal lymphoma were the second and third most common forms of lymphoma. The large cell/high-grade lymphoma type was much more common than the low-grade/small cell lymphoma in the study population. Domestic short hair was the most commonly affected breed in our study (n = 259/444). Among the cats with identified T/B-cell status, B-cell lymphoma (n = 61/81) prevailed as the most common phenotype. This study describes and characterizes the different types of feline lymphoma in cats in Hong Kong, adding valuable information to the body of knowledge.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong

Almendros,

Chan,

dos Santos Horta

et al. 2024

Animals

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Ginkgo biloba Extract Can Improve Well-Being and Life Expectancy of Cats (Felis catus) with Lymphoma

Martins

Oliveira²,

Rodrigues

et al. 2023

Rev. Bras. Farmacogn.

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Histopathological patterns and immunophenotyping of feline lymphomas and incidence in Metropolitan Bangkok, Thailand

Siripoonsub,

Sirivisoot,

Techangamsuwan

et al. 2024

Vet World

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Background and Aim: Feline lymphomas are categorized based on the location of tumor cells, with anatomical classifications including alimentary, mediastinal, multicentric, and extranodal forms. Accurate diagnosis and classification of feline lymphoma are paramount for enhancing treatment and prognosis. T-cell lymphomas are CD3 positive, while B-cell lymphomas exhibit positive for CD20, CD79α, and paired box 5 (PAX5). The aims of this study were (1) to classify feline lymphoma in each anatomical subtype using the World Health Organization (WHO) classification to provide information on epidemiological findings; (2) to investigate the expression and detection of B-cell lymphoma, various antibodies will be used, with the addition of PAX5, for clearer results; and (3) to gather more extensive information about feline lymphoma in Thailand, particularly in the Bangkok area. Materials and Methods: From 2011 to 2023, 86 sample tissues were submitted for routine pathological examination at the Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University. Immunohistochemistry (IHC) was performed to detect an immunophenotype of PAX5, CD79α, CD20 (B-cell lineage), and CD3 (T-cell lineage). Eighty-six formalin-fixed, paraffin-embedded lymphoma tissues were prepared on silane-coated slides. After IHC, all cases were classified according to the WHO classification. Results: The most common form of lymphoma in this study was extranodal lymphoma at 37.2% (32/86), followed by multicentric lymphoma at 31.3% (27/74), mediastinal lymphoma at 17.4% (15/86), and alimentary lymphoma at 14% (12/86). Most extranodal lymphoma cases were in the nasal region. From the anatomical form, multicentric and extranodal lymphomas were predominantly diffuse large B-cell high-grade, while mediastinal lymphomas were small low-grade B-cell lymphomas. Alimentary lymphomas occur in various types, with most being the B-cell type. Conclusion: This study indicates that extranodal lymphoma and extranodal lymphoma are the most frequent presentations found in cats in Bangkok. Mediastinal and alimentary lymphomas still occur. The utilization of various B-cell markers in combination could aid pathologists in distinguishing between various stages of B-cell maturation, assessing tumor cell heterogeneity, and determining the phenotype in scenarios where there is a loss of common B-cell markers diffuse large B-cell lymphomas is the most prevalent subtype of feline lymphoma. Significantly, relying solely on immunochemistry with one parameter may not be sufficient for a definitive diagnosis of B-cell lymphoma, as another parameter may also be necessary. Keywords: B-cell, feline, immunophenotype, incidence, lymphoma, t-cell.

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Feline lymphoma: diagnosis, staging and clinical presentations

Cited by 5 publications

References 64 publications

Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong

Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong

Ginkgo biloba Extract Can Improve Well-Being and Life Expectancy of Cats (Felis catus) with Lymphoma

Histopathological patterns and immunophenotyping of feline lymphomas and incidence in Metropolitan Bangkok, Thailand

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