Feline Panleukopenia Virus in Dogs from Italy and Egypt

Abstract

Canine parvovirus and feline panleukopenia virus (FPV) are variants of Carnivore protoparvovirus 1. We identified and characterized FPV in dogs from Italy and Egypt using genomic sequencing and phylogenetic analyses. Costeffective sequencing strategies should be used to monitor interspecies spread, evolution dynamics, and potential host jumping of FPV.

Old and Novel Enteric Parvoviruses of Dogs

“…In 1993, an isolate was obtained from a dog with acute gastro-enteritis, but the virus had features more similar to FPV [ 100 ]. More recently, the transmission of FPV to dogs with enteric clinical signs was reported in Pakistan, Thailand, Vietnam, China and Italy [ 79 , 94 , 95 , 102 , 103 , 104 ]. These viruses were characterized as FPV after either the partial or complete sequence analysis of the capsid gene.…”

“…These viruses were characterized as FPV after either the partial or complete sequence analysis of the capsid gene. The aa mutation from K to N at VP2 residue 93, involved in host range control, was observed in an FPV-like strain detected from a dog in Thailand [ 103 ] and the I101T mutation was identified in FPV-like strains detected from dogs in Vietnam [ 94 ], China [ 95 ] and Italy [ 104 ]. The pathogenetic role, if any, of FPV in dogs remains unclear.…”

Old and Novel Enteric Parvoviruses of Dogs

“…In 1993, an isolate was made from a typical clinical parvoviral infection in a dog, but the virus possessed properties more similar to FPV [100]. More recently, transmission of FPV to dogs with enteric clinical signs has been reported in Pakistan, Thailand, Vietnam, China and in Italy [79,94,95,[102][103][104]. These viruses have been characterized as FPV after either partial or complete sequence analysis of the gene encoding for the VP2.…”

“…These viruses have been characterized as FPV after either partial or complete sequence analysis of the gene encoding for the VP2. A unique K93N aa mutation involved in host range control was observed in an FPV-like strain in Thailand [103] and the I101T mutation was found in dog-associated FPV strains from Vietnam [94], China [95] and Italy [104]. The pathogenetic role, if any, of FPV in dogs remains unclear.…”

“…Sequencing of the canine TfR from FPV-infected dogs could help to understand the ability of FPV to infect some dogs [50]. Likewise, genome sequencing could be useful to monitor the spread, evolution, and potential host jumping of Protoparvovirus Carnivoron 1 variants in domestic and wild carnivores [104].…”