Feline Polycystic Kidney Disease: An Update

Schirrer, Lorie; Marín-Garcia, Pablo; Llobat, Lola

doi:10.3390/vetsci8110269

Cited by 14 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cysts are often thin, have a well-defined wall and no internal echoes or septations, and lack the extent of hepatic parenchymal involvement [ 18 , 19 , 20 ]. These hepatic cysts may be accompanied by polycystic kidney disease; therefore, the kidney should also be evaluated [ 21 , 22 , 23 ]. Polycystic kidney disease is an autosomal dominant genetic-related disease in Persian cats [ 21 , 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…These hepatic cysts may be accompanied by polycystic kidney disease; therefore, the kidney should also be evaluated [ 21 , 22 , 23 ]. Polycystic kidney disease is an autosomal dominant genetic-related disease in Persian cats [ 21 , 22 , 23 , 24 ]. In the cat described in this case report, polycystic kidney disease could be ruled out because the ultrasonography results for the kidneys were normal and the cat’s breed was domestic short-haired [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

Assawarachan

Yodsheewan

Maneesaay

et al. 2022

Animals

View full text Add to dashboard Cite

A 5-year-old female neutered domestic short-haired cat presented with abdominal enlargement. An abdominal ultrasound revealed that large multiple hepatic cysts with irregular walls, hypoechoic fluid, and internal septations occupied most of the liver parenchyma. Serum liver enzymes, bilirubin, and bile acids concentrations were within normal limits. A fecal examination using simple floatation and formalin-ether sedimentation techniques was negative for liver fluke (Platynosomum fastosum), intestinal protozoa, and other helminth eggs. Praziquantel was prescribed for two distinct courses one month apart without obvious improvement of the hepatic cysts. An abdominal laparotomy and histopathological examination finally enabled diagnosis of cyst-like lymphocytic cholangiohepatitis of the liver tissue. Twelve weeks of oral prednisolone resulted in marked ultrasonographic improvement of the hepatic cysts. The liver parenchyma was heterogeneous and filled with multiple small anechoic cavities. Twenty-three months after ceasing the prednisolone, there was no recurrence of hepatic cysts.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

Assawarachan

Yodsheewan

Maneesaay

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…It is one of this breed's most common feline genetic diseases, other than diabetes and feline lower urinary tract disease. 3 This disease not only impacts the Persian breed but other breeds, including the Exotic Shorthair, British Shorthair, American Shorthair, Himalayan, Scottish fold, Ragdoll, Chartreaux, and Maine Coon breeds, may also be affected by this disease. [4][5][6] The polycystin-1 (PKD1) gene mutation was indicated for 85% of human autosomal dominant polycystic kidney disease (ADPKD).…”

Section: Introductionmentioning

confidence: 99%

PKD1 gene mutation and ultrasonographic characterization in cats with renal cysts

Jaturanratsamee,

Jiwaganont,

Sukumolanan

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: Polycystic kidney disease (PKD) has a complex phenotype partly explained by genetic variants related to this disease. Ultrasonography is a promising approach for defining clinical signs. This study aimed to assess kidney characteristics in cats with Polycystin-1 (PKD1) gene mutations and wild-type cats. Kidney characteristics were identified by ultrasonography. Methods: A total of 108 cats of variable breeds aged an average of 37.01±3.50 months were included. Blood examination and biochemical tests were evaluated. For cystic formation, renal ultrasound was performed. The PKD1 gene mutation was identified via polymerase chain reaction (PCR) and DNA sequencing. Matrix correlation and effectiveness of ultrasound for PKD1 mutation detection were determined. Results: The results showed that 19.44% of cats had PKD1 mutations, a high prevalence in Persian and Persian-related breed cats. Our results demonstrated the characteristics of kidneys in wild-type cats and cats with gene mutations. Based on ultrasonography results, there was an association between cats with gene mutations and cyst formation. The findings indicated that ultrasound did not detect cysts in cats aged 4-36 months, supporting the evidence that PKD1 gene mutations may not be present. This study found high sensitivity and renal specificity ultrasound for PKD1 heterozygous mutation. Moreover, cystic formation via renal ultrasound showed an increased risk for PKD1 mutation 2,623 times compared to normal kidneys. Conclusions: Ultrasonographic examination, coupled with genetic investigations, may help to clarify the phenotypic variability of PKD1. The phenotypic profile of PKD1 will guide therapeutic outcomes and reduce the prevalence of PKD morbidity and mortality in cats.

show abstract

“…PKD is recognized as the most common hereditary disorder in cats, occurring in approximately 6% of the overall feline population with a notably higher prevalence observed in Persian breeds ( 12 ). It has been elucidated that the PKD1 gene or other genes within this locus contribute to the pathogenesis of feline PKD ( 13 , 14 ). PKD is characterized by the progressive diversification of the size and number of cysts over time, eventually leading to chronic renal failure ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: A novel occurrence of persistent left cranial vena cava coexisting with polycystic kidney disease in a cat

Cha,

Ro,

Song

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

A 7-year-old castrated male Munchkin cat was presented with anorexia. This cat had been diagnosed with chronic kidney disease due to polycystic kidney disease. Tachycardia with a systolic murmur (grade III/VI) was auscultated and for further diagnosis, echocardiography was performed. Based on echocardiography, persistent left cranial vena cava (PLCVC) was suspected due to enlargement of the coronary sinus and confirmed by saline contrast echocardiography. The dilated coronary sinus compressed the left atrium, and left ventricular hypertrophy with the systolic anterior motion of the mitral valve, aortic regurgitation, and mitral regurgitation were identified. After medical management using atenolol, left atrial function and other hemodynamics of the heart were improved, including the disappearance of regurgitation and normalization of left ventricular wall thickness. This case report describes the echocardiographic characteristics, diagnostic procedures, and disease progression in a cat with PLCVC after medical management using atenolol. Additionally, this is the first report of a cat with PLCVC, coexisting with polycystic kidney disease.

show abstract

Feline Polycystic Kidney Disease: An Update

Cited by 14 publications

References 45 publications

Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

Feline Cyst-like Lymphocytic Cholangiohepatitis in a Cat: First Case Report

PKD1 gene mutation and ultrasonographic characterization in cats with renal cysts

Case report: A novel occurrence of persistent left cranial vena cava coexisting with polycystic kidney disease in a cat

Contact Info

Product

Resources

About