Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

Zhang, Shutao; Qu, Xinhua; Jiao, Juyang; Tang, Haozheng; Wang, Minqi; Wang, You; Yang, Hongtao; Yuan, Weien; Yue, Bing

doi:10.1016/j.bioactmat.2021.11.019

Cited by 14 publications

(16 citation statements)

References 51 publications

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“…Traditional antibiotics still suffer from issues of efficacy and feasibility [ 14 , 15 ]. They are not able to target bone infection sites and are unsuccessful at the biofilm, resulting in unsatisfactory therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Nie

Huo

et al. 2022

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Nie

Huo

et al. 2022

Bioactive Materials

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“…An evaluation of the hemolytic activity of NPs was performed by conducting hemolysis of rat erythrocytes using a previously described procedure. [ 43 ] A fresh whole blood sample was collected from anesthetized rats using heparin‐containing anticoagulation tubes and blood lancets. The red blood cells were subsequently separated from whole blood through centrifugation (3000 rpm, 5 min) and washed with sterile PBS three times at 4 °C.…”

Section: Methodsmentioning

confidence: 99%

“…[40] Biofilms can not only form on the skin and teeth, but also attach to medical implants such as catheters and prostheses, leading to continuous infection. [41] According to the National Institutes of Health (NIH) of the United States of America, 80% of bacterial infections in the body are related to bacterial biofilms, [42,43] so it is crucial to impair or even inhibit the formation of biofilms during treatment. Therefore, Ti6Al4V disks were used as the biofilm growth substrate, and the inhibitory effect of the NPs on MRSA biofilms was observed by confocal laser scanning microscopy (CLSM) (Figure 5b).…”

Section: Antibacterial Activity Against Mrsamentioning

confidence: 99%

Core–Shell Nanoparticle Combined with Bacterial Targeting and Antibiotic Loading for Bacteria Tracing and Clearing

Hong

Huo

Guo

et al. 2022

Advanced NanoBiomed Research

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Bacterial infections are a major complication in human healthcare. Bacteria tracing and targeted delivery of antibiotics to bacterial infection sites are being developed to reduce the high mortality caused by pathogenic bacterial infections. Owing to the challenges in accurate diagnosis of infection, particularly the identification of biomaterial‐related bacteria, the use of bacteria‐targeting nanomaterials has become increasingly important. Herein, magnetic core–shell mesoporous silica nanoparticles (MSNs) are fabricated for targeted drug delivery; the shell is modified with ubiquicidin (UBI)29‐41 for bacteria targeting, and vancomycin is loaded into the channels of the MSNs. The results demonstrate that magnetic core–shell MSNs display the desired functions of drug loading, bacteria targeting, detectability in magnetic resonance imaging, antibacterial action, and good in vitro biocompatibility. Magnetic core–shell MSNs have potential applications in the treatment of diseases caused by infections.

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“…The use of traditional antibiotic therapies for PJI still has problems that cannot be solved; they do not effectively target the site of bone infection, leading to unsatisfactory treatment outcomes Frontiers in Bioengineering and Biotechnology frontiersin.org (Zhang et al, 2022). Therefore, bone-targeted and bacterial-targeted therapies have been extensively studied in bone infections.…”

Section: Targeting Nanoparticle-antibiotics Delivery Vehiclementioning

confidence: 99%

Recent advances in prevention, detection and treatment in prosthetic joint infections of bioactive materials

Xie

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Prosthetic joint infection (PJI) is often considered as one of the most common but catastrophic complications after artificial joint replacement, which can lead to surgical failure, revision, amputation and even death. It has become a worldwide problem and brings great challenges to public health systems. A small amount of microbe attaches to the graft and forms a biofilm on its surface, which lead to the PJI. The current standard methods of treating PJI have limitations, but according to recent reports, bioactive materials have potential research value as a bioactive substance that can have a wide range of applications in the field of PJI. These include the addition of bioactive materials to bone cement, the use of antibacterial and anti-fouling materials for prosthetic coatings, the use of active materials such as bioactive glasses, protamine, hydrogels for prophylaxis and detection with PH sensors and fluorescent-labelled nanoparticles, and the use of antibiotic hydrogels and targeting delivery vehicles for therapeutic purposes. This review focus on prevention, detection and treatment in joint infections with bioactive materials and provide thoughts and ideas for their future applications.

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Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms

Cited by 14 publications

References 51 publications

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Bone infection site targeting nanoparticle-antibiotics delivery vehicle to enhance treatment efficacy of orthopedic implant related infection

Core–Shell Nanoparticle Combined with Bacterial Targeting and Antibiotic Loading for Bacteria Tracing and Clearing

Recent advances in prevention, detection and treatment in prosthetic joint infections of bioactive materials

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