Felty's syndrome. Clinical and serological analysis of 34 cases.

Sienknecht, Charles W.; Urowitz, Murray B.; Pruzanski, W.; Stein, H

doi:10.1136/ard.36.6.500

Cited by 82 publications

(41 citation statements)

References 23 publications

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“…6,65 A much higher incidence (75%) is seen in those with RAassociated Felty syndrome. 66 Rheumatoid nodules are relatively frequent in the white population and affect males more than their female counterparts. 57,67,68 RF-seropositive patients are quite susceptible.…”

Section: Classic Rheumatoid Nodulesmentioning

confidence: 99%

Rheumatoid arthritis: A review of the cutaneous manifestations

Sayah

English

2005

Journal of the American Academy of Dermatology

220

147

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Section: Classic Rheumatoid Nodulesmentioning

confidence: 99%

Rheumatoid arthritis: A review of the cutaneous manifestations

Sayah

English

2005

Journal of the American Academy of Dermatology

220

147

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“…Focal and mesangial glomerulonephritis has been described in RA patients with Felty's syndrome (25). Our patient had hepatomegaly, but no splenomegaly or significant neutropenia suggestive of Felty's syndrome.…”

Section: Discussionmentioning

confidence: 67%

Glomerulonephritis in rheumatoid arthritis

Davis

Cohen

Weisbart

et al. 1979

Arthritis & Rheumatism

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Glomerulonephritis is rarely a complication of rheumatoid arthritis (RA) despite the observation of significant amounts of circulating immune complexes in both glomerulonephritis and RA (1). Among 5,232 patients with a diagnosis of RA, hospitalized at the UCLA Center for the Health Sciences from 1955 to 1977, glomerulonephritis was diagnosed in only 4 patients, all of whom also met diagnostic criteria for systemic lupus erythematosus or mixed connective tissue disease. We present a well documented case of proliferative glomerulonephritis in association with RA in the absence of another immunologically mediated disease.

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“…These patients frequently have severe joint destruction, rheumatoid nodules, lymphadenopathy, vasculopathy, a prominence of extraarticular features, and hepatic pathology. Systemic symptoms including fever and substantial weight loss occur in 65% of patients [75]. Hepatomegaly occurs in 67-68% of patients and 56% have abnormalities in liver function tests [75,76], higher than that seen in uncomplicated RA.…”

Section: Felty's Syndromementioning

confidence: 98%

Gastrointestinal and Hepatic Manifestations of Rheumatoid Arthritis

Ebert

Hagspiel

2011

Dig Dis Sci

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Rheumatoid arthritis (RA), characterized by inflammation of the synovium and surrounding structures, has a prevalence of 0.5-1%. Rheumatoid vasculitis (RV) is an inflammatory condition of the small- and medium-sized vessels that affects up to 5% of patients with RA with intestinal involvement in 10-38% of these cases. Clinically apparent RV of the gastrointestinal (GI) tract, while rare, is often catastrophic, resulting in ischemic ulcers and bowel infarction. Vasculitis of the colon may present as pancolitis clinically similar to ulcerative colitis. Rectal biopsies that include submucosal vessels are positive for vasculitis in up to 40% of cases. Abnormal esophageal motility in RA may result in heartburn and dysphagia. Chronic atrophic gastritis may be associated with hypergastrinemia and hypo- or achlorhydria, promoting small bowel bacterial overgrowth. RA is the most common cause of secondary amyloidosis with GI symptoms in 22% of affected patients. Although amyloid is usually found in the liver, it is rarely evident clinically. Felty's syndrome occurs in less than 1% of patients with RA and is characterized by neutropenia and splenomegaly. The liver may be involved with portal fibrosis or nodular regenerative hyperplasia. Liver histology is abnormal in 92% of RA patients at autopsy, although the changes are usually mild without associated hepatomegaly. Drug-induced liver disease may occur with aspirin, sulfasalazine, and methotrexate. Significant liver damage is rare if the drug is discontinued or the patient is properly monitored. RA can affect both the GI tract and the liver; changes are usually mild except with RV.

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Felty's syndrome. Clinical and serological analysis of 34 cases.

Cited by 82 publications

References 23 publications

Rheumatoid arthritis: A review of the cutaneous manifestations

Rheumatoid arthritis: A review of the cutaneous manifestations

Glomerulonephritis in rheumatoid arthritis

Gastrointestinal and Hepatic Manifestations of Rheumatoid Arthritis

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