In order to reveal the dynamic response mechanism of silo-storage-foundation system under seismic wave loading, the silo is simplified as a thin-walled cylindrical shell structure with fixed bottom and free upper part. Considering geometric nonlinearity, dynamic elastic modulus, damping and other factors, the nonlinear vibration differential equations of the silo under dynamic loading are established. The Galerkin method is used to discretize the vibration differential equations, and the definite conditions with solution ideas are given. Subsequently, the dynamic action system of tube supported reinforced concrete silos is studied by using the shaking table test method. The similarity theory of silo model test is constructed, and the experimental model of the silo storage foundation interaction system with the geometric ratio of 1:20 is established, where three seismic waves in the suitable engineering background are selected to carry out the shaking table test. The acceleration peak value at different heights of the model is measured, and the dynamic amplification factor of the silo model along the height direction is studied under different seismic intensity and different material condition. The seismic performance of the prototype structure is studied, which provides the theoretical basis and practical guidance for the design of silo system and the operation and management of silos.