Female adnexal tumor of probable wolffian origin.A Distinctive Pathologic Entity

Kariminejad, Mohammad Hasan; Scully, Robert E.

doi:10.1002/1097-0142(197303)31:3<671::aid-cncr2820310328>3.0.co;2-k

Cited by 174 publications

(101 citation statements)

References 24 publications

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“…They were characterized by a mostly solid proliferation of small and closely packed cells punctured by numerous small to cystic glands, imparting a superficial resemblance to FATWO. 4,5 Twelve of 26 endometrioid carcinomas of the fallopian tube in a study by Navani et al 6 were wolffian-like. To our knowledge, so far there have been 20 reported cases of endometrioid carcinoma of the fallopian tube resembling FATWO in the English literature.…”

Section: Discussionmentioning

confidence: 99%

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Endometrioid Carcinoma of the Fallopian Tube Resembling a Female Adnexal Tumor of Probable Wolffian Origin

Fukunaga

Bisceglia²,

Dimitri³

2004

Advances in Anatomic Pathology

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Endometrioid carcinoma of the fallopian tube resembling a female adnexal tumor of probable wolffian origin (FATWO) is a rare, recently delineated, low-grade carcinoma that may be confused with both FATWO and high-grade carcinoma. Only about 20 cases have been reported so far, but it probably represents almost half of the endometrioid carcinomas of the fallopian tube. It has a better prognosis than conventional tubal endometrioid and serous carcinomas. Macroscopically, the tumors form a small, solid, polypoid mass that is usually confined within the tube. Microscopically, the tumors are characterized by proliferations of spindle cells in whorls and closely packed confluent elongated glands with focal tubular, sieve-like, and papillary structures. Unlike FATWO, this variant of endometrioid carcinoma exhibits focal squamous differentiation, intraluminal mucin, mild to moderate nuclear atypia, and occasional mitosis. Unlike FATWO, tumor cells are negative for inhibin-alpha and calretinin.

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Section: Discussionmentioning

confidence: 99%

“…The tumor arose from the fallopian tube, whereas FATWO typically arises outside the tube within the broad ligament or ovary. 4,5 The presence of squamous differentiation was more in keeping with endometrioid carcinoma. The degree of nuclear atypia and mitotic activity was more impressive than is seen in FATWO.…”

Section: Discussionmentioning

confidence: 99%

Endometrioid Carcinoma of the Fallopian Tube Resembling a Female Adnexal Tumor of Probable Wolffian Origin

Fukunaga

Bisceglia²,

Dimitri³

2004

Advances in Anatomic Pathology

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“…Unlike endometrioid adenocarcinoma, FATWO is positive for inhibin and calretinin. 223,224 It is also positive for cytoplasmic CD10 and negative for EMA. [224][225][226] The immunophenotype of serous carcinoma of the fallopian tube is similar to that of the ovary and peritoneum.…”

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confidence: 99%

The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders

Kaspar

Crum

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Immunohistochemistry has assumed an increasing role in the identification and characterization of gynecologic disorders including lesions with deceptively bland morphology, uncommon and underdiagnosed neoplasms, and neoplasms with specific genetic alterations associated with overexpression or loss of expression of specific proteins. The diagnostic accuracy has been significantly improved owing to the discovery and increasing experience with the tumor-associated biomarkers, and the increasing demand for precise tumor classification to assess suitability for the expanding therapeutic modalities including clinical trials. Objective To differentiate lesions of the gynecologic tract through the use of effective immunohistochemical panels. Data Sources Literature review and authors' personal practice experience. Conclusions The application of diagnostic and prognostic immunohistochemical panels has enabled pathologists to better guide therapeutic decisions and to better predict the clinical outcome. It is now well established that the use of ancillary testing, including immunohistochemistry, has a significant power in the identification, differentiation, and classification of reactive, premalignant, and malignant gynecologic disorders. This article discusses the utilities and pitfalls of the commonly used immunohistochemical markers in the context of overlapping morphologic features encountered in the uterus, ovaries, and fallopian tubes.

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“…FATWO is a rare, poorly understood lesion and was first described in 1973. 1 It is defined as a tumor of presumptive wolffian origin characterized by a variety of epithelial patterns and occurs in the broad ligament, mesosalpinx, fallopian tube, ovary, and peritoneum. 2,3 Metastasis to the vermiform appendix from any primary tumor is a very rare clinical entity as well and only scattered case reports were published.…”

Section: Figurementioning

confidence: 85%

Metastatic Female Adnexal Tumor of Possible Wolffian Origin (FATWO) of the Appendix Demonstrated by FDG PET/CT

Liu

2011

Clinical Nuclear Medicine

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Both female adnexal tumor of possible wolffian origin (FATWO) and metastasis to the appendix from any primary tumor are extremely rare entities. The appendiceal metastasis from FATWO has not been reported, and there is a lack of the literature regarding FDG PET/CT study in both. We reported the case of an appendiceal metastasis from FATWO, demonstrated by F-18 FDG PET/CT. The case highlights the significance of FDG uptake in the appendix. When interpreting FDG PET/CT, caution should be exercised to identify uptake in the appendix, because it is easily misinterpreted as bowel activity.

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Female adnexal tumor of probable wolffian origin.A Distinctive Pathologic Entity

Cited by 174 publications

References 24 publications

Endometrioid Carcinoma of the Fallopian Tube Resembling a Female Adnexal Tumor of Probable Wolffian Origin

Endometrioid Carcinoma of the Fallopian Tube Resembling a Female Adnexal Tumor of Probable Wolffian Origin

The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders

Metastatic Female Adnexal Tumor of Possible Wolffian Origin (FATWO) of the Appendix Demonstrated by FDG PET/CT

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