Female adnexal tumor of Wolffian origin: Case report of a rare tumor

Bal, Himadri; Agrawal, Sharda A; Kumar, Harsh; Shokeen, Versha

doi:10.4103/mjdrdypu.mjdrdypu_71_18

Cited by 2 publications

(5 citation statements)

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“…Pathology Update: Tropical Journal of Pathology & Microbiology Available online at: www.medresearch.in 743 | P a g e ligament, mesosalpinx and ovarian hilum in females with a wide age range (15-72 years). [17][18][19][20] They are characterised by a wide variety of histological patterns, some of which closely simulate other pelvic tumors. The diagnosis of FATWO is based mainly on its topography and its morphologic appearance of a sievelike retiform pattern of hollow tubules and cysts, closely packed tubules, and diffuse solid sheets of cells.…”

Section: Case Reportmentioning

confidence: 99%

An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential

Singh

Bhargava

et al. 2019

Trop J Pathol Microbiol

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Background: Though Granulosa cell tumors (GCTs) are the most common ovarian sex cord stromal tumors, they are very rare in extra ovarian sites with a handful of cases reported in retroperitoneum, broad ligament, fallopian tube, mesentery and even in the adrenals. Female Adnexal Tumor of probable Wolffian Origin (FATWO), which is also a very rare tumor comes up as its closest differential because of a significant overlap of topographic, morphologic, and immunohistochemical (IHC) features. Case Summary: Present case is of a post-menopausal female who complained of abdominal swelling and post-menopausal bleeding. On CT, she was shown to have a broad ligament mass (fibroid) which was excised. On histopathological reporting the tumor showed mainly the lesser known morphological variants of GCT that lead to difficulty in reaching at the exact diagnosis and a differential of an extraovarian GCT [eGCT] vs. FATWO was given which on IHC finally turned out to be an eGCT. Conclusion: Broad ligament is the site of two very rare tumors of the female genital tract, i.e. eGCT and FATWO which are close mimickers of each other not only on topography, but also on morphology and immunohistochemistry. Hence distinguishing between these two entities may be quite challenging for a pathologist, but aid of certain features can be taken to arrive at the diagnosis many a times.

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Section: Case Reportmentioning

confidence: 99%

An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential

Singh

Bhargava

et al. 2019

Trop J Pathol Microbiol

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“…It can also occur within the areas where mesonephric remnants are distributed mainly in mesosalpinx, serosa of fallopian tube, ovary and retroperitoneum. Rarity of this tumour and lack of strong recommendation about its work-up renders it difficult to diagnose pre-operatively [1] . Neither definitive treatment nor follow-up protocol is available because of the varied presentation, different age-groups of patients, size of tumour and ranging malignant potentiality.…”

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confidence: 99%

“…Discussion: FATWO also called retiform Wolffian adenoma is rare tumour. World-wide about 80-90 cases have been reported till now [1] . To the best of our knowledge, this is third case report and also first case with mutation study from India.…”

Section: Introductionmentioning

confidence: 99%

“…The average age of presentation is approximately 50 years (Range 15-83 years). Clinically often patients are asymptomatic or they may be incidentally detected as an abdominal mass or adnexal mass [1,3] . Ultrasound is the first imaging tool often used which may reveal an ill-defined mass.…”

Section: Introductionmentioning

confidence: 99%

“…Differential diagnoses include subserosal leiomyoma or an ovarian tumour and it may be difficult to differentiate these lesions from FATWO by MRI findings. Studies have shown normal preoperative tumour maker levels such as Ca-125 [1,3] . Accurate diagnosis of FATWO may be made depending on its anatomical site, morphological features and IHC pattern [3] .…”

Section: Introductionmentioning

confidence: 99%

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Female adnexal tumour of Wolffian origin (FATWO) arising from broad ligament: A rare case report with mutation analysis and review of literature

Murthy¹,

Avinash²,

Bv³

et al. 2019

Int. J. Clin. Obstet. Gynaecol.

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Female adnexal tumour of Wolffian origin (FATWO) is a rare tumour arising from persisting remnants of mesonephric duct. World-wide less than 100 cases have been reported. Diagnosis of this tumour is mainly post-operative based on histopathological examination and Immunohistochemistry (IHC) markers. We report this rare case in a 48 year old woman. She was diagnosed, pre-operatively, to have left ovarian mucinous cystadenoma by radiology imaging. Post-operatively, histopathological examination reported this tumour as FATWO arising from the left broad ligament. The diagnosis was confirmed by IHC markers. Further mutational studies were also carried out. According to the literature search, this is the third case reported in INDIA, until now. Rarity and varied presentation of this tumour, makes the pre-operative diagnosis difficult. If sufficient numbers of these cases are reported, pre-operative investigations, treatment and follow-up protocols for this tumour can be formulated.

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Female adnexal tumor of Wolffian origin: Case report of a rare tumor

Cited by 2 publications

References 2 publications

An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential

An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential

Female adnexal tumour of Wolffian origin (FATWO) arising from broad ligament: A rare case report with mutation analysis and review of literature

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