Female breast cancer in different age groups: clincopathological features and treatment strategies

Nuzhat, Ayesha; Abouzaid, Lamyaa Z.

doi:10.18203/2394-6040.ijcmph20171746

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…The higher rate of BC in young patients in our cohort is comparable with the previous data from Saudi women reported by Nuzhat et al 23 and Elkum et al 24 from Riyadh also observed a higher rate of BC (25.2%-33.2%) in young women in Saudi Arabia than the women from the western countries (3.7%-6.6%).…”

Section: Discussionsupporting

confidence: 92%

“…22 However, it is significantly higher than the 3.7%-6.6% reported in many Western countries. [4][5][6][7] The higher rate of BC in young patients in our cohort is comparable with the previous data from Saudi women reported by Nuzhat et al 23 and older patients (p=0.174). IDC: invasive ductal carcinoma, ILC: invasive lobular carcinoma, DCIS: ductal carcinoma in situ, LCIS: lobular carcinoma in situ receptors-positive (p=0.0001, p<0.0001) and more likely to be triple-negative (p=0.008).…”

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confidence: 90%

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Clinicopathological characteristics of young versus older patients with breast cancer

Albasri

2021

SMJ

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To compare the clinicopathological, histological and immunohistochemical features of breast cancer (BC) in between young (≤40 years) and older (>40 years) patients.Methods: This retrospective study included histopathological reports of all patients with primary BC diagnose at the King Fahad Hospital, Madinah, Saudi Arabia between January 2006 and November 2020. Original ArticleResults: During the study period, a total of 708 patients with BC were identified; 173 cases (24.4%) were ≤40 years old and 535 (75.6%) were above 40 years. There were significant differences in tumor size (p=0.046), tumor grade (p<0.0001), tumor stage (p=0.047), lymphovascular invasion (p<0.0001), and distant metastasis (p<0.0001) between the 2 groups. Comparing the status of the hormone receptors and molecular subtypes between the 2 age groups, BCs in the younger patients were triple-negative (p=0.008) in majority of the cases and less likely to be estrogen receptor (ER) and progesterone receptor (PR) hormone receptors-positive (p=0.0001, p<0.0001). Young patients exhibited the HER2/neu type with more frequent statistical significance (p=0.016) and the tumor type luminal A (p=0.002) with less frequent statistical significance compared to old patients. Conclusion:Although BC in young women is uncommon, it may be different with regards to poor prognostic outcomes, which are attributed to more aggressive histopathological features and less favorable receptor status when compared to the cases diagnosed in older women.

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Section: Discussionsupporting

confidence: 92%

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confidence: 90%

Clinicopathological characteristics of young versus older patients with breast cancer

Albasri

2021

SMJ

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“…15 Nuzhat in his study, 39 (25.2%) patients were less than or equal to 40 years of age, 60 (38.7%) were more than 40 to 50 years and 56 (36.1%) were more than 50 years of age with the median age at diagnosis being 47 years. 16 Mehradad et al from Iran in the year 2016 recorded data of 258 patients with breast cancer and reported that the mean age of the patients at diagnosis was 44.2 years (range: 25-71 years).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological study of various breast diseases in different age groups

Kapur¹,

Walia²,

Singh³

et al. 2017

Int. J. Curr. Res. Med. Sci

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Breast diseases are a common finding in India. Despite advances in imaging technology, invasive histopathological studies, and surgical techniques, the diagnosis and management of breast diseases continues to be demanding and complex. Aim: Considering the importance of breast disorders among females, the present study was undertaken to find out prevalence and different clinicopathological aspects of various breast diseases in different age groups. Material and methods: Two hundred cases of breast diseases coming to the outpatient and indoor department of the Guru Nanak Dev Hospital/Govt. Medical College, Amritsar (Punjab) were studied. The clinical features, methods of diagnosis and management were studied. A detailed history-taking and clinical examination was done on all the patients. All patients, as and when indicated, underwent USG breast, mammography, FNAC and core needle biopsy of the lesion. Patients were followed up during and after treatment. Results: Out of the 200 patients taken into study, the most common pathology was fibroadenoma (41.7%) and most patients presented between 11-20 years (32 cases) of age group followed by 21-30 years (24 cases) of age group. followed by fibroadenosis (21.5%) with maximum age incidence in the age group of 31-40 years. Inflammatory diseases of the breast formed 10.7% of benign breast diseases in our study and maximum age incidence found between 21-40 years of age. Granulomatous pathology constituted 8 % and were in between 31-40 years of age group. Carcinoma breast was reported maximum above the age of 50 years (32 cases) in this study followed by 41-50 years (22 cases) and it constituted 30.5% of all breast diseases. Other diseases reported include galactocele (2 cases), gynecomastia (2 cases), and accessory breast (2 cases).

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“…To date, studies comparing the two populations have included limited data on patient- and disease-specific characteristics [ 5 , 11 , 12 ]. More importantly, multiple aspects of BC specifics remain to be addressed in these populations.…”

Section: Introductionmentioning

confidence: 99%

Do site and type of metastasis in breast cancer show a changing pattern with increased age? A cross comparison of clinicopathological characteristics between age groups

et al. 2018

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BackgroundIn here, we evaluated pattern of metastasis and cross-compared clinicopathological features between different age groups with breast cancer (BC).MethodsThis study was conducted in the Shiraz Breast Cancer Registry (largest BC registry in Iran). Patients were classified as < 30 years old (group 1), 30–60 years old (group 2), and > 60 years old (group 3). The three age groups were compared regarding clinical and baseline characteristics.ResultsOverall, 564 individuals entered group 1, 4519 group 2, and 670 group 3.Group 1 had lower rates of tumor necrosis (p < 0.001), higher lymphatic or vascular invasion (p = 0.002), estrogen receptor-negative individuals, and HER2-positive individuals (p ≤ 0.001).Younger groups had more stage 3 BC (31.1, 25.6, and 19.7% for groups 1, 2, and 3, respectively) (p = 0.016), grade 3 BC (27.4, 20.6, and 16.5% for groups 1, 2, and 3, respectively) (p = 0.001), and grade 3 nucleus (43.1, 34.5, and 27.6% for groups 1, 2, and 3, respectively) (p < 0.001).Group 1 had higher rates of regional metastasis (4.7 vs. 1.5 and 2.1% for groups 2 and 3, respectively). Younger individuals had higher rates of brain metastasis (13.3, 5.4, and 1.1% for groups 1, 2, and 3, respectively). Moreover, those > 60 years old had more lung metastasis (33 vs. 12.6 and 6.7% for groups 2 and 1, respectively) (p < 0.001).Younger groups had more < 5-year recurrence (16.3, 11.7, and 8.9%, for groups 1, 2, and 3, respectively) (p = 0.023).ConclusionPattern and site of recurrence changes according to age in BC. This brings up the question whether age is an independent predictor of organ of metastasis or is site of metastasis the result of other clinicopathological determinants which differ between age groups.

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Female breast cancer in different age groups: clincopathological features and treatment strategies

Cited by 3 publications

References 26 publications

Clinicopathological characteristics of young versus older patients with breast cancer

Clinicopathological characteristics of young versus older patients with breast cancer

Clinicopathological study of various breast diseases in different age groups

Do site and type of metastasis in breast cancer show a changing pattern with increased age? A cross comparison of clinicopathological characteristics between age groups

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