Female donors and donors who are lighter than their recipient are less likely to meet the <scp>CD</scp>34+ cell dose requested for peripheral blood stem cell transplantation

Billen, Annelies; Madrigal, J. Alejandro; Szydlo, Richard; Shaw, Bronwen E.

doi:10.1111/trf.12720

Cited by 21 publications

(23 citation statements)

References 40 publications

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“…Vasu and colleagues reported a reduced post–G‐CSF CD34+ cell count in females in their analysis of 639 allogeneic donors. Others found the same correlation …”

Section: Discussionsupporting

confidence: 58%

“…Beside the donor‐related factors described, the recipient weight has a relevant influence on the harvest success in allogeneic donations . The ROC analysis shows that harvest success can already be predicted reasonably well, based on recipient weight and donor sex.…”

Section: Discussionmentioning

confidence: 99%

“…Further, higher body weight or an elevated BMI were associated with a better mobilization potential of the donor . Interestingly, recent murine experiments have shown that the adipose tissue has several structural similarities with the marrow and contains significant numbers of HSCs .…”

Section: Discussionmentioning

confidence: 99%

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Prediction of hematopoietic stem cell yield after mobilization with granulocyte–colony‐stimulating factor in healthy unrelated donors

et al. 2015

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“…Vasu and colleagues reported a reduced post–G‐CSF CD34+ cell count in females in their analysis of 639 allogeneic donors. Others found the same correlation …”

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prediction of hematopoietic stem cell yield after mobilization with granulocyte–colony‐stimulating factor in healthy unrelated donors

et al. 2015

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“…12,[23][24][25][26][27][28] In this small cohort, the strongest predictors of higher CD34 cell mobilization were younger age, higher baseline platelet count, higher baseline circulating CD34, and higher AUC of plerixafor. Other factors associated with CD34 mobilization were CXCL12 change from baseline to 30 minutes, male gender, and a lower graft content of pDCs.…”

Section: Discussionmentioning

confidence: 99%

Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft

Schroeder

Rettig

López

et al. 2017

Blood

114

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• Plerixafor is a safe, effective, rapid mobilizing agent when administered intravenously.• Lower rates of GVHD and CMV viremia with plerixaformobilized grafts may be related to a unique cellular composition of the graft.A single subcutaneous (SC) injection of plerixafor results in rapid mobilization of hematopoietic progenitors, but fails to mobilize 33% of normal allogeneic sibling donors in 1 apheresis. We hypothesized that changing the route of administration of plerixafor from SC to IV may overcome the low stem cell yields and allow collection in 1 day. A phase 1 trial followed by a phase 2 efficacy trial was conducted in allogeneic sibling donors. The optimal dose of IV plerixafor was determined to be 0.32 mg/kg. The primary outcome of reducing the failure to collect ‡2 3 10 6 CD34 1 /kg recipient weight in 1 apheresis collection to £10% was not reached. The failure rate was 34%. Studies evaluating the stem cell phenotype and gene expression revealed a novel plasmacytoid dendritic cell precursor preferentially mobilized by plerixafor with high interferon-a producing ability. The observed cytomegalovirus (CMV) viremia rate for patients at risk was low (15%), as were the rates of acute grade 2-4 graft-versus-host disease (GVHD) (21%). Day 100 treatment related mortality was low (3%). In conclusion, plerixafor results in rapid stem cell mobilization regardless of route of administration and resulted in novel cellular composition of the graft and favorable recipient outcomes. These trials were registered at clinicaltrials.

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“…Peripheral blood stem cells are obtained through mobilization of HSPC with G‐CSF, followed by at least one leucocytapheresis . There are many donor‐dependent factors influencing the outcome of the procedure, such as gender, age, ethnicity, body mass index (BMI), smoking, iron status, pre‐G‐CSF platelet count, pre‐G‐CSF mononuclear count, pre‐G‐CSF white blood cell (WBC) count or weight difference between the donor and the recipient . Studies show that people with a history of blood donation are more likely to register as potential haematopoietic progenitor cell (HPC) donors, yet to our best knowledge, there is a lack of data in the literature regarding the impact of prior blood donation on the outcome of HPC mobilization outcomes .…”

Section: Introductionmentioning

confidence: 99%

Prior blood donations do not affect efficacy of G‐CSF mobilization nor outcomes of haematopoietic stem cell collection in healthy donors

et al. 2019

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Background and Objectives Many consider volunteer blood donors as ideal candidates for unrelated haematopoietic progenitor cell (HPC) donation. However, frequent blood donations could influence the results of HPC mobilization. To our best knowledge, there are no data on the possible impact of repeated blood donation on efficiency of subsequent HPC mobilization by granulocyte colony‐stimulating factor (G‐CSF). Materials and Methods We compared outcomes of HPC mobilization in unrelated donors with and without a history of blood donation. We conducted a prospective study on 287 consecutive donors admitted to the Department of Hematology since January 2016. The final analysis included 153 donors who agreed to take part in the study and had undergone stem cell mobilization with G‐CSF. Results History of blood donations prior to haematopoietic stem cell mobilization with G‐CSF does not have a significant impact on the number of collected CD34+ cells in the first leucocytapheresis (516.2 x 106 (170–1148) in blood donors vs 490.5 x 106 (101–1154) in non‐donors) (P = 0.32). In all donors, in this study mobilization of HPC was successful: 87.5% of blood donors and 85.6% of non‐donors collected the required cell number in a single apheresis. In blood donors, a higher number of blood donations within 2 and 5 years prior to HPC mobilization correlated significantly with successful donation within one leucocytapheresis (P = 0.014 and P = 0.024, respectively). Conclusion Multiple blood donations do not significantly influence the outcome of HPC collection in unrelated donors. Blood donors and non‐donors have similar results of HPC collection, so there is no reason to favour either group.

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Female donors and donors who are lighter than their recipient are less likely to meet the CD34+ cell dose requested for peripheral blood stem cell transplantation

Cited by 21 publications

References 40 publications

Prediction of hematopoietic stem cell yield after mobilization with granulocyte–colony‐stimulating factor in healthy unrelated donors

Prediction of hematopoietic stem cell yield after mobilization with granulocyte–colony‐stimulating factor in healthy unrelated donors

Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft

Prior blood donations do not affect efficacy of G‐CSF mobilization nor outcomes of haematopoietic stem cell collection in healthy donors

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