Female fertility, obstetric and gynaecological history in coeliac disease: a case control study

Sher, K; Mayberry, J F

doi:10.1111/j.1651-2227.1996.tb14258.x

Cited by 94 publications

(91 citation statements)

References 4 publications

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“…47 Moreover, there is also a greater frequency of recurrent miscarriages (mainly in the first 3 months of pregnancy), stillbirth and neonatal death. 48 In males, impotence, decreased sexual activity, infertility, abnormalities of sperm morphology and motility may be expressions of CD. 49,50 Another presentation of atypical CD is so-called celiac hepatitis, characterized by a gluten-dependent increase in serum transaminases without abnormality of any other liver functions.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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Until a few years ago, celiac disease (CD) was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal mucosa. Currently, CD is regarded as an autoimmune disorder that is common in the general population (affecting 1 in 100 individuals), with possible onset at any age and with many possible presentations. The identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal (constipation and recurrent abdominal pain) and extra-intestinal symptoms (anemia, raised transaminases, osteoporosis, recurrent miscarriages, aphthous stomatitis and associated autoimmune disorders), or it could be completely symptomless. Over the last 20 years, the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests, such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide antibodies. The routine use of antibody markers has allowed researchers to discover a very high number of 'borderline' cases, characterized by positive serology and mild intestinal lesions or normal small intestine architecture, which can be classified as potential CD. Therefore, it is evident that the 'old celiac disease' with flat mucosa is only a part of the spectrum of CD. It is possible that serology could identify CD in its early stages, before the appearance of severe intestinal damage. In cases with a positive serology but with mild or absent intestinal lesions, the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

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Section: Introductionmentioning

confidence: 99%

Celiac disease: diagnostic criteria in progress

2011

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“…In addition, adverse effects on the mother may also occur, as indicated by a recent German study which demonstrated that the rate of cesarean delivery is increased if the parents have CD [8].…”

Section: Introductionmentioning

confidence: 99%

“…There are many problems seen in CD that may affect a woman's ability to achieve a pregnancy like delay of menarche and menstrual disorders (ovulation problems), putting in mind sub fertility may be immune mediated, it is near to some studies, conducted in Europe and Mid east, it emphasized, CD has been associated with sub fertility, as well as it is consistent with Canadian study in 2008, revealed that, CD may be a significant contributor to fertility problems in women, as well as studies that carried out by Sher et al ,. Collin and colleagues and Certain study that was performed in Sardinia by Meloni et al, Swedish study concluded that women with CD overall had normal fertility and this explained by the modality of life of Swedish women [19][20][21].…”

Section: Citation: Hassan Sm Yassin K Zakaria Na (2017) Reproductivmentioning

confidence: 99%

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Reproductive Health Indicators Among Women with Celiac Disease in Sudan at Ibn Sina Specialized Hospital from December 2014 to June 2015

Hassan¹

2017

RMGO

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Celiac disease is associated with reproductive disorders, including delayed menarche, menstrual disturbances, unexplained sub fertility, and endometriosis. There is an established relationship between overt Hassan SM, et al., J Reprod Med Gynecol Obstet 2017 Background: Celiac disease is an immune-mediated mucosal disorder primarily affecting the small intestine in genetically-susceptible individuals. It may be triggered by dietary exposure to gluten. In some patients, extra-intestinal or autoimmune changes may occur, as hepatobiliary, neurological, or endocrine disorders. The aim to study the reproductive health indicators among Sudanese female with celiac disease (15-45 years) and to determine menstrual pattern, infertility status as well as obstetrical outcome among those women at Ibn sina specialized hospital from December 2014 to June 2015. Material and Methods:This is a descriptive analytic hospital based study, carried out at Ibn sina specialized hospital, conducted from December 2014 to June 2015, included 81 women, diagnosed as celiac disease, attended celiac clinic during the study period. The data was collected using a questionnaire by me after agreed informative consent and analyzed by computer using SPSS program (20).Results: 32 (39.5%) of women were between 25-34 years and 58 (71.6%) of women were on strict gluten diet. 52 (64.1%) of women had menarche after age of 16, 30 (37%) experienced oligomenorrhoea and 2 (2.5%) had secondary amenorrhoea and their menstrual pattern was improved with gluten free diet (P value 0.002), 36 (44.4%) of women were married, 21 (58.3%) of these women experienced difficulty in conceiving which affected by the duration of their disease(P value 0.000), 23 (63.9%), 21(58.3%) had past history of miscarriage and pregnancy induced hypertension respectively. Conclusion: celiac disease has a significant role in women reproductive health, in the form of delay menarche, a change of menstrual pattern, difficulty in conceiving, and poor obstetric outcome such as miscarriage and pregnancy induced hypertension.

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“…En la mujer, la enfermedad celiaca ha sido asociada a alteraciones obstétri-cas y ginecológicas, como infertilidad, abortos de repetición, bajo peso al nacimiento, menor duración de la lactancia materna, entre otros. Sin embargo, los datos de las series publicadas no siempre coinciden en estas apreciaciones (6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

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