Female Fertility Preservation in Cancer Patients: An Instrumental Tool for the Envisioning a Postdisease Life

Trèves, R; Grynberg, Michaël; Parco, Sergio; Finet, Astrid; Poulain, Marine; Fanchin, Rénato

doi:10.2217/fon.13.265

Cited by 27 publications

(30 citation statements)

References 19 publications

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“…18,19,25,30 In this cohort of reproductive-aged, female AYA cancer survivors, a large proportion across all cancer types and treatment exposures reported reproductive concerns as measured using the RCAC scale, 10 highlighting the need to address these cancer-specific reproductive health concerns after treatment. 18,19,25,30 In this cohort of reproductive-aged, female AYA cancer survivors, a large proportion across all cancer types and treatment exposures reported reproductive concerns as measured using the RCAC scale, 10 highlighting the need to address these cancer-specific reproductive health concerns after treatment.…”

Section: Discussionmentioning

confidence: 95%

“…2 Fertility loss can be a devastating consequence of cancer treatments for AYA survivors, resulting in poorer quality of life. 10 In addition to the adverse impact of infertility itself, unmet informational needs on fertility are also associated with distress. 10 In addition to the adverse impact of infertility itself, unmet informational needs on fertility are also associated with distress.…”

Section: Introductionmentioning

confidence: 99%

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Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors

Young

Shliakhtsitsava

Natarajan

et al. 2018

Cancer

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BACKGROUND: Fertility counseling before cancer treatment has been advocated by clinical guidelines, though little is known about its long-term impact on the unique reproductive concerns of female adolescent and young adult (AYA) cancer survivors. The goal of this study was to measure the association between fertility counseling by fertility specialists before cancer treatment and subsequent reproductive concerns. METHOD: A cross-sectional analysis was performed among 747 AYA survivors aged 18-40 years who had been recruited from cancer registries and physician and advocacy group referrals between 2015 and 2017. Participants self-reported information on past fertility counseling at cancer diagnosis, cancer type and treatment, and current reproductive concerns, as measured using the multidimensional Reproductive Concerns After Cancer scale. Multivariable log-binomial regression models tested associations between fertility counseling and reproductive concerns. RESULTS: The mean age of the cohort was 33.0 years (standard deviation, 5.1 years), and the mean period since diagnosis was 7.7 years (standard deviation, 5.0 years). Seventy-three percent of participants were white, and 24% were Hispanic. Fertility counseling was reported by 19% of survivors; moderate to high overall reproductive concerns were reported by 44% of participants. In adjusted analysis, fertility counseling was significantly associated with moderate to high reproductive concerns (risk ratio, 1.22; 95% confidence interval, 1.02-1.45) and not modified by exposure to fertility-threatening treatments (P interaction = .23). CONCLUSION: A large proportion of AYA cancer survivors across cancer types and treatment exposures reported moderate to high reproductive concerns, suggesting that there is a need to address these cancer-specific reproductive health concerns after treatment. Higher concerns, even with counseling, suggests the need to improve the quality of fertility counseling throughout the cancer continuum. Cancer 2019;125:980-989.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors

Young

Shliakhtsitsava

Natarajan

et al. 2018

Cancer

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“…This ultimately leads to the empowerment of patients, enabling them to make independent decisions about their future, especially regarding the prospect of having their own children. Furthermore, education regarding fertility issues at diagnosis and prior to cancer treatment is a humanising experience for patients and parents that can strengthen the desire for recovery …”

Section: Discussionmentioning

confidence: 99%

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

et al. 2019

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Introduction/Objectives Fertility preservation is a major concern for adolescent cancer patients; yet, educational gaps remain. Our intervention study examined whether specially designed educational materials regarding fertility preservation increase knowledge and empowerment of patients and parents. Methods Eleven paediatric‐oncological centres in four European countries agreed to enrol all eligible patients and parents in a questionnaire survey at 3 and 6 months after diagnosis. Treating physicians were surveyed on their medical consultation regarding fertility. Results Educational intervention increased knowledge in both patients (n = 113 and n = 101 in the control and intervention groups, respectively) and parents (n = 111 and n = 99 in the control and intervention groups, respectively), but the difference did not achieve statistical significance (knowledge difference patients: 5.6% (t0)/13.1% (t1); parents: 6.4% (t0)/3.8% (t1)). Parents of older patients (OR = 1.3, 95%CI = 1.1‐1.7) and higher educational groups (OR = 6.2, 95%CI = 2.1‐18.3) in the intervention group (OR = 1.9, 95%CI = 1.03‐3.7) achieved higher knowledge levels. Empowerment was significantly improved in both patients (p = 0.046, d = 0.27) and parents (p = 0.046, d = 0.48) in the intervention group. Discussion/Conclusions In our study, the use of specifically prepared flyers and brochures successfully raised the level of fertility preservation knowledge in parents of older patients as well as parents with higher educational levels. Overall, the intervention improved patient and parent empowerment. Subsequent projects will include simpler information and digital material to particularly reach out to younger and less educated individuals.

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“…When we changed the keyword to "oncofertility" there were 48 articles in English. Of those, only 9 was clinical articles and the remaining 39 was mainly review articles and expert opinions in this subject [2,[4][5][6][7][8][9][10][11].…”

Section: Search and Selection Criteriamentioning

confidence: 99%

Oncofertility for gynecologic and non-gynecologic cancers: Fertility sparing in young women of reproductive age

Dursun

Doğan

Ayhan

2014

Critical Reviews in Oncology/Hematology

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Female Fertility Preservation in Cancer Patients: An Instrumental Tool for the Envisioning a Postdisease Life

Abstract: The present results indicate that the simple fact of undergoing FP improves the patients' subjective experience of cancer treatments.

Cited by 27 publications

References 19 publications

Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors

Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors

Fertility knowledge and associated empowerment following an educational intervention for adolescent cancer patients

Oncofertility for gynecologic and non-gynecologic cancers: Fertility sparing in young women of reproductive age

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