Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura, Hiroki; Ando, Koji; Shinmyo, Takuo; Morita, Katsusada; Mochizuki, Atsushi; Kurimoto, Noriaki; Tatsunami, Shinobu

doi:10.5761/atcs.oa.10.01637

Cited by 120 publications

(80 citation statements)

References 86 publications

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“…The survival advantage for women after surgery for NSCLC has been documented to be independent of age at diagnosis, stage, histology, and life expectancy (6,16). Women had higher FEV1% prior to surgery, which may be indicative of a lower rate of smoking and of underlying lung disease, such as COPD.…”

Section: Discussionmentioning

confidence: 97%

“…Female gender has also been identified as a positive prognostic factor for survival after lung cancer diagnosis as well as after lung resection in NSCLC, with one study reporting a hazard ratio of 0.5 at 5 years after resection (5)(6)(7)16). Lower rates of smoking, COPD, and pre-existing cardiovascular disease in women better explain differences in prolonged air leaks, and consequently in chest tube days and hospital LOS, as FEV1 ≤80% of predicted is a known risk factor (35,36).…”

Section: Discussionmentioning

confidence: 99%

“…Gender has been shown to be an independent risk factor for and to affect prognosis and the histology of lung cancer (4)(5)(6). Women are more likely to develop adenocarcinoma, which has been partly attributed to a greater rate of mutations in the epidermal growth factor receptor (EGFR) gene, which codes for a tyrosine kinase that regulates cell proliferation and apoptosis, and which suggests that there may be a gender-related response to treatment as well (7).…”

Section: Introductionmentioning

confidence: 99%

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Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

et al. 2016

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Background: Female gender has been associated with worse outcomes after cardiovascular surgery and critical illness. We investigated the effect of gender on perioperative outcomes following robotic-assisted pulmonary lobectomy. 44.5%; P=0.004), the most common of which, in both women and men, were prolonged air leak for ≥7 days (13.0% vs. 22.7%, P=0.03), atrial fibrillation (7.1% vs. 14.8%, P=0.04), and pneumonia (7.8% vs. 10.2%, P=0.49). Hospital length of stay (LOS) (4±0.3 vs. 5±0.5 days) was also shorter for women (P=0.02). Despite the higher postoperative complication rate in men, in-hospital mortality did not differ between genders (P=0.23). Multivariable analyses did not identify female gender as an independent predictor of post-operative complications. Conclusions: Female gender was associated with rates of intraoperative complications and of conversion to open lobectomy as low as those for men, but with better perioperative outcomes, lower risk of intraoperative bleeding, and fewer postoperative complications. Thus, robotic-assisted pulmonary lobectomy is feasible and safe for women.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

et al. 2016

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“…12,13) Various factors such as age, sex, smoking habit, ethnicity, tumor size, SUVmax, visceral pleural invasion, lymphatic invasion, and venous invasion have been reported to predict survival in surgical cases of NSCLC. [14][15][16][17][18][19][20][21][22][23][24][25] However, only a few reports have analyzed AD and SQ separately. In the present study, the most powerful prognostic factors for RFS and OS in AD were histologic pleural invasion.…”

Section: Discussionmentioning

confidence: 99%

Difference in Postsurgical Prognostic Factors between Lung Adenocarcinoma and Squamous Cell Carcinoma

Nakamura

Sakai

Kimura

et al. 2017

ATCS

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IntroductionLung adenocarcinoma (AD) and squamous cell carcinoma (SQ) are the two major histologic types of nonsmall-cell lung cancer (NSCLC), and have been considered to be almost similar in both postsurgical prognosis and chemotherapeutic responses for a long period of time. However, recent multiple studies on the postsurgical outcomes of these two histologic types Difference in Postsurgical Prognostic Factors between Lung Adenocarcinoma and Squamous Cell CarcinomaHaruhiko Nakamura, MD, PhD, Hiroki Sakai, MD, Hiroyuki Kimura, MD, Tomoyuki Miyazawa, MD, Hideki Marushima, MD, PhD, and Hisashi Saji, MD, PhD Purpose: The aim of this study was to compare the clinicopathologic prognostic factors between patients who underwent lung resection for adenocarcinoma (AD) and those with squamous cell carcinoma (SQ). Methods: A database of patients with lung AD or SQ who underwent surgery with curative intent in our department from January 2008 to December 2014 was reviewed. Associations between various clinicopathologic factors, postsurgical recurrence-free survival (RFS), and overall survival (OS) were analyzed to find significant prognostic factors. Results: A total of 537 lung cancer patients (AD, 434; SQ, 103) were included in this study. Although RFS was similar in patients with AD and SQ, OS was significantly poorer in those with SQ. Multivariate analysis in patients with AD revealed that age (≥69 vs. <69), lymphatic invasion, and histologic pleural invasion (p0 vs. p1-3) were associated with RFS, while gender and pleural invasion were associated with OS. In SQ, however, smoking, clinical stage, and pulmonary metastasis were associated with RFS in the multivariate analysis. Conclusion: Since significant postoperative prognostic factors are quite different between lung AD and SQ, these two histologic types should be differently analyzed in a clinical study.

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“…Una serie de estudios indican que la supervivencia del cáncer de pulmón es mejor en mujeres que en hombres, independientemente del estadio, la histología, o el tratamiento (Fu et al, 2005;Janjigian et al, 2010;Micheli et al, 2009;Nakamura et al, 2011;Ries et al, 2007;Sagerup, Smastuen y Johannesen, 2001;Salmeron et al, 2012;Wakelee et al, 2012;WheatleyPrice et al, 2010). Según los datos de la SEER, la su-a235 pervivencia relativa a 5 años para mujeres con cáncer de pulmón es del 18,2% comparada con el 14,5% en hombres.…”

Section: Pronóstico Del Cáncer De Pulmón En Mujeresunclassified

El cáncer de pulmón en mujeres

Felip

2015

Arbor

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Hospital Universitari Vall d'Hebronefelip@vhebron.net RESUMEN: El cáncer de pulmón es la enfermedad maligna más frecuente en el mundo. En los últimos diez años en España, la mortalidad por cáncer de pulmón ha aumentado un 20% en las mujeres frente a un 5% en los hombres, debido a los cambios recientes de patrones de hábito tabáquico entre ambos sexos. El tabaco sigue siendo la causa única más importante de una enfermedad prevenible en un alto porcentaje de casos. Es muy importante que la población conozca esta realidad y que modifique el estilo de vida, eliminado el tabaquismo, para poder detener esta epidemia que representa el cáncer de pulmón. En este artículo se revisarán aspectos epidemiológicos, así como factores de riesgo, características y pronóstico de las mujeres con cáncer de pulmón, con una especial atención a la población española. PALABRAS CLAVE: adenocarcinoma; EGFR; tabaco.ABSTRACT: Lung cancer is the most frequent malignant disease in the world. Over the last ten years lung cancer mortality has risen in Spain by 20% among women compared with 5% among men. This is due to recent changes in both genders' smoking habits. Tobacco is still the single most important cause of a preventable disease in a high percentage of cases. It is extremely important that the population is aware of this and that people modify their lifestyle accordingly, giving up smoking in order to halt the lung cancer epidemic. In this article, we review epidemiological aspects, as well as risk factors, characteristics and the prognosis for women with lung cancer, focusing particularly on the Spanish population.

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Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Cited by 120 publications

References 86 publications

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

Effect of gender on perioperative outcomes after robotic-assisted pulmonary lobectomy

Difference in Postsurgical Prognostic Factors between Lung Adenocarcinoma and Squamous Cell Carcinoma

El cáncer de pulmón en mujeres

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