Female genital mutilation/cutting (FGM/C) is a harmful traditional practice with severe health implications among women and girls. This study determined whether knowledge reduced the practice of female genital mutilation and identified the socio-demographic factors that predicted the practice of female genital among parents in Ekiti State, Nigeria. A cross-sectional quantitative research method was employed among 600 selected parents in the three senatorial districts of Ekiti-State, Nigeria between March and June 2019. A pretested structured questionnaire was used to collect data. Our analysis revealed that 468 (78%) of the respondents believed that the practice was high as against 132 (22%) who said the practice was low. Female is two times more likely to practice FGM than male (OR = 1.614, B = 0.479, p < 0.05, CI = 1.088-2.394). Respondents with low knowledge were significantly 11 times likely to practice female genital mutilation compared with respondents with high knowledge (OR = 10.597, B = 2.361, p < 0.05, CI = 6.813-16.483). Those who lived in rural areas were two times significantly (OR = 1.690, B = 0.525, p < 0.05, CI = 3. 246-13.197) likely to practice female genital mutilation than the urban dwellers. The study concluded that respondents' knowledge, location (urban/rural), sex, age, and ethnicity were strong predictors of the practice of FGM/C in Ekiti-State, Nigeria. With these findings in mind, the community institutions would play a great role in changing the community through spreading information about the health implications of FGM/C for the practice to be drastically reduced.