Female migraineurs show lack of insular thinning with age

Maleki, Nasim; Barmettler, Gabi; Moulton, Eric A.; Scrivani, Steven J.; Veggeberg, Rosanna; Spierings, Egilius L.H.; Burstein, Rami; Becerra, Lino; Borsook, David

doi:10.1097/j.pain.0000000000000159

Cited by 44 publications

(47 citation statements)

References 88 publications

(113 reference statements)

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“…Multiple studies have reported abnormalities associated with the insula in migraine . Both fMRI and PET studies have shown that the insula is activated during migraine attacks, and there are higher glutamate levels in the insula of migraineurs .…”

Section: What Have We Learned So Far?mentioning

confidence: 99%

What Have We Learned From Brain Functional Connectivity Studies in Migraine Headache?

Maleki

Gollub

2016

Headache

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Over the past 20 years, headache syndromes, especially migraine, have benefited significantly from the knowledge gained through neuroimaging studies. This article is focused on the neuroimaging studies of the functional organization and connectivity of the migraine brain. First, data sources and the study design elements in functional neuroimaging studies of the brain connectivity in migraine headaches are discussed. Then, the article reviews the findings to date and discusses how functional connectivity studies have contributed to a better understanding of the mechanisms of the migraine disease by extending the focus from a single region or structure to a network of regions and structures and the interactions among them. Finally, the potential scenarios for the translation of connectivity knowledge to the benefit for patients are discussed.

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Section: What Have We Learned So Far?mentioning

confidence: 99%

What Have We Learned From Brain Functional Connectivity Studies in Migraine Headache?

Maleki

Gollub

2016

Headache

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Section: Discussionmentioning

confidence: 99%

“…b Model 1 was adjusted for age, gender, education years, APOE ε4 carrier status, MoCA-T score, and intracranial volume; Model 2 was additionally adjusted for degree of white matter lesion, lacunes, hypertension, diabetes mellitus, body mass index, and smoking. found in patients with chronic musculoskeletal pain, abdominal pain, migraine or smoking addiction 39,[41][42][43] . In patients with mild AD, depression and anxiety symptoms were found to be associated with thinning of the insular cortex 44 .…”

Section: Discussionmentioning

confidence: 99%

Effect of kidney dysfunction on cerebral cortical thinning in elderly population

Chen

Tsai

et al. 2017

Journal of the Neurological Sciences

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Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m 2 or presence of proteinuria. Kidney dysfunction was associated with lower global (β = −0.05, 95% CI = −0.08 to −0.01) as well as frontal, parietal, temporal, occipital, and insular lobar CTh. In the stratified analysis, the associations were more pronounced in women, APOEε4 non-carriers, and participants with a lower cognitive score. Besides, kidney dysfunction significantly increased the risk of cortical thinning, defined as being the lowest CTh tertile, in the insular lobe (adjusted odds ratio = 2.74, 95% CI = 1.31−5.74). Our results suggested that kidney dysfunction should be closely monitored and managed in elderly population to prevent neurodegeneration.The worldwide incidence and prevalence of dementia is increasing rapidly in persons of advanced age, which results in a huge global disease burden 1 . Currently, it is estimated that 46.8 million people worldwide are living with dementia, although in some developed countries the prevalence is gradually lowering possibly due to higher education levels and better control of cardiovascular risk factors 2, 3 . Long before clinically evident dementia-related functional impairment, generalized brain atrophy progresses gradually and asymptomatically with age, beginning at middle age 4 . Therefore, it is important to identify potentially preventable factors related to brain atrophy during the subclinical phase. Consequently, the structural neuroimaging, among various potential biomarkers for dementia, serves most closely temporal relationship with the onset of clinically detectable cognitive impairment 5 . The most commonly applied structural neuroimaging technique is magnetic resonance imaging (MRI). In various MRI imaging sequences, physicians can use three-dimensional T1-weighted images that clearly delineate the volume, shape, and thickness of the respective cerebral cortex. Specifically, the volume of cortical regions is a composite measure related to both thickness and surface area. In these two morphometric parameters, cortical thickness more closely reflects pathological changes related to dementia, such as laminar thinning and neuronal loss, while volume loss is largely the result of a reduction in surface area during normal aging 6 . Several factors have been linked to dementia, such as age, sex, education, apolipoprotein E (APOE) ε4 status, and various cardiovascular risk factors such as hypertension, diabetes mellitus, metabolic syndrome, and stroke 7 . In recent years, brain-kidney interaction is increasingly emphasized. Chronic kidney disease (CKD) and

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“…Although the function of the insula was not fully understood, it was usually linked to emotional process, autonomic function and interoception 39,40 . Abnormal changes in insular cortical thickness have been found in patients with chronic musculoskeletal pain, abdominal pain, migraine or smoking addiction 39,[41][42][43] . In patients with mild AD, depression and anxiety symptoms were found to be associated with thinning of the insular cortex 44 .…”

Section: Discussionmentioning

confidence: 99%

[P3–344]: Effect of Kidney Dysfunction on Cerebral Cortical Thinning in an Elderly Population

Chen

Chiu

et al. 2017

Alzheimer's & Dementia

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Chronic kidney disease has been linked to cognitive impairment and morphological brain change. However, less is known about the impact of kidney functions on cerebral cortical thickness. This study investigated the relationship between kidney functions and global or lobar cerebral cortical thickness (CTh) in 259 non-demented elderly persons. Forty-three participants (16.7%) had kidney dysfunction, which was defined as either a glomerular filtration rate (GFR) of <60 ml/min/1.73 m 2 or presence of proteinuria. Kidney dysfunction was associated with lower global (β = −0.05, 95% CI = −0.08 to −0.01) as well as frontal, parietal, temporal, occipital, and insular lobar CTh. In the stratified analysis, the associations were more pronounced in women, APOEε4 non-carriers, and participants with a lower cognitive score. Besides, kidney dysfunction significantly increased the risk of cortical thinning, defined as being the lowest CTh tertile, in the insular lobe (adjusted odds ratio = 2.74, 95% CI = 1.31−5.74). Our results suggested that kidney dysfunction should be closely monitored and managed in elderly population to prevent neurodegeneration.The worldwide incidence and prevalence of dementia is increasing rapidly in persons of advanced age, which results in a huge global disease burden 1 . Currently, it is estimated that 46.8 million people worldwide are living with dementia, although in some developed countries the prevalence is gradually lowering possibly due to higher education levels and better control of cardiovascular risk factors 2, 3 . Long before clinically evident dementia-related functional impairment, generalized brain atrophy progresses gradually and asymptomatically with age, beginning at middle age 4 . Therefore, it is important to identify potentially preventable factors related to brain atrophy during the subclinical phase. Consequently, the structural neuroimaging, among various potential biomarkers for dementia, serves most closely temporal relationship with the onset of clinically detectable cognitive impairment 5 . The most commonly applied structural neuroimaging technique is magnetic resonance imaging (MRI). In various MRI imaging sequences, physicians can use three-dimensional T1-weighted images that clearly delineate the volume, shape, and thickness of the respective cerebral cortex. Specifically, the volume of cortical regions is a composite measure related to both thickness and surface area. In these two morphometric parameters, cortical thickness more closely reflects pathological changes related to dementia, such as laminar thinning and neuronal loss, while volume loss is largely the result of a reduction in surface area during normal aging 6 .Several factors have been linked to dementia, such as age, sex, education, apolipoprotein E (APOE) ε4 status, and various cardiovascular risk factors such as hypertension, diabetes mellitus, metabolic syndrome, and stroke 7 . In recent years, brain-kidney interaction is increasingly emphasized. Chronic kidney disease (CKD) and

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Female migraineurs show lack of insular thinning with age

Cited by 44 publications

References 88 publications

What Have We Learned From Brain Functional Connectivity Studies in Migraine Headache?

What Have We Learned From Brain Functional Connectivity Studies in Migraine Headache?

Effect of kidney dysfunction on cerebral cortical thinning in elderly population

[P3–344]: Effect of Kidney Dysfunction on Cerebral Cortical Thinning in an Elderly Population

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