Female Obesity and Infertility

Talmor, Alon; Dunphy, Bruce C.

doi:10.1016/j.bpobgyn.2014.10.014

Cited by 269 publications

(201 citation statements)

References 42 publications

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“…Obesity is already recognized as a disease that interferes with fertility [28,29]. Obesity may affect a woman's fertility via numerous events, such as impairment of ovarian follicles development, qualitative and quantitative defects in oocyte maturation, altered fertilization, disrupted meiosis, and mitochondrial dynamics de- rangements leading to abnormal embryo preimplantation [30].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Kim

Lee

Yun

et al. 2018

Gynecol Obstet Invest

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Aims: Our objective was to predict natural pregnancy after endometriosis surgery using the endometriosis fertility index (EFI). Methods: A retrospective medical records review was conducted, examining patients surgically treated for endometriosis at a single center in Korea between January 2009 and February 2015. In total, 68 women attempting natural conception were analyzed by assessing age, preoperative serum CA-125, body mass index, revised American Fertility Society (rAFS) stage, EFI, and pregnancy outcome. Kaplan-Meier estimates and log-rank tests were used to generate cumulative natural pregnancy rate curves based on an EFI cut-point. A receiver-operating characteristic (ROC) curve was plotted for EFI. Results: Seventy-seven patients attempted conceptions, resulting in 33 natural and 9 assisted conceptions. Excluding assisted conceptions, the mean EFI scores of 68 women who were not pregnant and pregnant were 5.43 ± 0.36 and 6.88 ± 0.28 respectively. The relation between EFI and natural pregnancy was significant (cumulative overall pregnancy rate, p = 0.006), whereas rAFS stage was not (univariate logistics, p = 0.853). The cut-point for maximum natural pregnancy outcomes was 6 (area under ROC curve = 0.710, 95% CI 0.586–0.835). Conclusion: The EFI is a reliable staging system for predicting natural pregnancy after endometriosis surgery. EFI scores can be used to guide postoperative treatment of women with endometriosis.

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Section: Discussion/conclusionmentioning

confidence: 99%

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Kim

Lee

Yun

et al. 2018

Gynecol Obstet Invest

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“…Pre-pregnancy obesity is also associated with increased health risks for the offspring, such as foetal defects, congenital anomalies, pre-mature birth, stillbirth, large for gestational age (LGA) and shoulder dystocia [88]. Furthermore, obesity is associated with menstrual cycle dysregulation, anovulation and infertility; fertility and conception hence constitute major motivators for women with obesity and associated infertility to undergo bariatric surgery [90,91]. …”

Section: Pregnancy After Bariatric Surgerymentioning

confidence: 99%

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management

et al. 2017

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Bariatric surgery is today the most effective long-term therapy for the management of patients with severe obesity, and its use is recommended by the relevant guidelines of the management of obesity in adults. Bariatric surgery is in general safe and effective, but it can cause new clinical problems and is associated with specific diagnostic, preventive and therapeutic needs. For clinicians, the acquisition of special knowledge and skills is required in order to deliver appropriate and effective care to the post-bariatric patient. In the present recommendations, the basic notions needed to provide first-level adequate medical care to post-bariatric patients are summarised. Basic information about nutrition, management of co-morbidities, pregnancy, psychological issues as well as weight regain prevention and management is derived from current evidences and existing guidelines. A short list of clinical practical recommendations is included for each item. It remains clear that referral to a bariatric multidisciplinary centre, preferably the one performing the original procedure, should be considered in case of more complex clinical situations.

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“…794 Obesity has become a recent worldwide epidemic in the past decades, especially in developed countries, where the prevalence of obesity reached 50% (Talmor and Dunphy, 2015). Obesity is undoubtedly a useful clinical predictor of metabolic abnormalities which can be detected in the early stages of PCOS and, sometimes, it even precedes its development.…”

Section: Int J Adv Res 5(12) 793-796mentioning

confidence: 99%

Polycystic Ovarian Syndrome in Women With Obesity.

AhmedN¹

2017

IJAR

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Female Obesity and Infertility

Cited by 269 publications

References 42 publications

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study

Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management

Polycystic Ovarian Syndrome in Women With Obesity.

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