Female obesity: Association with endocrine disruption and reproductive dysfunction

Baraskar, Kirti; Thakur, Pratibha; Shrivastava, Renu; Shrivastava, Vinoy K.

doi:10.1016/j.obmed.2021.100375

Cited by 14 publications

(7 citation statements)

References 251 publications

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“…These adipokines have the ability to influence the function of the ovary and the production of sex hormones. This crosstalk may also involve insulin-like peptides (ILPs) and signaling pathways such as Akt (protein kinase B), which transduce signals in the fat body tissue as well as in the ovaries [13]. Additionally, the fat body's potential as a target for ovary rejuvenation has been observed through methods such as autologous platelet-rich plasma (PRP) injections.…”

Section: Discussionmentioning

confidence: 99%

Multimodal metabolic imaging of the ovary under diet manipulation during aging process

Li,

Jiang,

et al. 2024

Multiphoton Microscopy in the Biomedical Sciences XXIV

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Lipid and protein metabolism play important roles in the aging process of ovary. High resolution in situ optical imaging provides a powerful approach to study the metabolic dynamics of macro-molecules such as lipids and proteins. Here, we applied a multimodal imaging platform integrated with D2O probing stimulated Raman scattering (DO-SRS), multiphoton fluorescence (MPF), and second harmonic generation (SHG) to explore metabolic changes of biomolecules in Drosophila ovaries during aging process. In this study, the sub-cellular spatial distribution of de novo protein synthesis, lipogenesis and redox ratio in ovaries are quantitatively imaged and examined in different ages. The regulation of diets on aging-dependant changes of ovary metabolism are investigated. Our results provide valuable insights for the underlying mechanism of ovary aging and how to intervene the aging process to achieve a better health

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Section: Discussionmentioning

confidence: 99%

Multimodal metabolic imaging of the ovary under diet manipulation during aging process

Li,

Jiang,

et al. 2024

Multiphoton Microscopy in the Biomedical Sciences XXIV

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“…PCOS inhibits the function of gut microorganisms, which in turn disrupts in ammatory signalling in the HPG axis and oocyte formation; it also causes reproductive cycle anomalies, a rise in body mass index (BMI), and alterations in the result of assisted reproductive treatment. Kisspeptin-dependent leptin pathways increase the control of GnRH secretion to maintain ovarian function, and disrupted ovarian-pituitary and hypothalamic feedback exacerbates the gonadotrophin abnormalities, with accumulating evidence involving disruption of the Kiss 1 system [22]. Neuroendocrine dysfunction seen in PCOS develops early in adolescence, and all phases of puberty are accompanied by hyperandrogenism in obese females, which is related with increased LH pulsatility.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study on factors associated with secondary amenorrhoea among the students who attended Polyclinic Universiti Malaysia Sabah with irregular menstruation

Than

Parash

Majeed³

et al. 2023

Preprint

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Background The menstruation is considered as an indicator of women’s health. A woman who menstruates regularly (every 21–45 day) is considered to have secondary amenorrhea if she has not menstruated in 3 months or 6 months if she menstruates previously irregular. Hypothalamic amenorrhea (HA) and polycystic ovary syndrome (PCOS) are the two most common causes of secondary amenorrhoea, other than pregnancy. The changes in the female hormone levels are associated with health behaviours, obesity, and stress. High stress has been shown to affect the hypothalamic–pituitary–adrenal (HPA) axis activity, whereas high body mass index (BMI) has been demonstrated to influence the sex hormone-binding globulin (SHBG), free androgen index (FAI), testosterone, and insulin levels. Objectives The objective of the study is to study body mass index (BMI), stress score and hormonal levels on students from Universiti Malaysia Sabah (UMS) who attended Polyclinic UMS with irregular menstruation to detect the causes of irregular menstruation and to give specific treatment to improve their quality of life. Method Cross-sectional study was carried out during the period starting from 1st January 2021 until 31st December 2022 on UMS students with an age range of (19–35 years), both undergraduate and postgraduate, attended the Polyclinic UMS for irregular menstruation. The subjects who received hormonal treatment in the past six months, with organic lesions of the genital tract, with bleeding disorders, and with pregnancy, were excluded from the study. In this study total of 100 participants were included through stratified random sampling where 60 subjects were recruited who fulfilled the selection criteria, and the rest 40 subjects were recruited as matched controls. Result As the subjects were selected as matched pairs, both the groups had a similar frequency of different BMI grades. The p-value was higher than the level of significance, α = 0.05 and there was insufficient evidence to reject the null hypothesis. There were some apparent differences in the frequencies of depression, anxiety, and stress (DASS 21 score) between the two groups. The p-values for depression (0.004), anxiety (< 0.001), and stress (0.003) were less than the level of significance, α = 0.05 and the null hypothesis was rejected. The p-values of LH, testosterone, oestradiol, and TSH were lower than the significant level α = 0.05, but for FSH, prolactin and free T4 were higher. There was sufficient evidence to reject the null hypothesis for LH, testosterone, oestradiol, and TSH, but the evidence was insufficient to reject the null hypothesis for FSH, prolactin, and free T4. Hence, there was a significant difference in LH, testosterone, oestradiol, and TSH levels. Conclusion The causes of secondary amenorrhoea in students from Universiti Malaysia Sabah (UMS) who attended Polyclinic UMS with irregular menstruation were functional hypothalamic amenorrhoea due to stress with or without weight loss and polycystic ovary syndrome due to overweight and obesity as well as chronic life stressful events. Lifestyle modification and stress management are first-line treatment plans to improve their quality of life.

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“…In this respect, it is worth mentioning that inflammation and hyperinsulinemia in girls can boost the production of sex hormones through different mechanisms, as schematized in Figure 2. 31,32 On the one hand, insulin promotes the secretion of the gonadotropin-releasing hormone (GnRH), which subsequently stimulates the release of LH and FSH in the hypothalamic-pituitary-gonadal (HPG) axis, and finally triggers estrogen biosynthesis in ovaries. Alternatively, insulin is also known to enhance the metabolism of androgens and glucocorticoids that is mediated by the adrenocorticotropic hormone (ACTH) in adrenal glands.…”

Section: Male Subjectsmentioning

confidence: 99%

Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones

et al. 2023

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Although growing evidence points to a pivotal role of perturbed metal homeostasis in childhood obesity, sexual dimorphisms in this association have rarely been investigated. In this study, we applied multi‐elemental analysis to plasma and erythrocyte samples from an observational cohort comprising children with obesity, with and without insulin resistance, and healthy control children. Furthermore, a wide number of variables related to carbohydrate and lipid metabolism, inflammation, and sex hormones were also determined. Children with obesity, regardless of sex and insulin resistance status, showed increased plasma copper‐to‐zinc ratios. More interestingly, obesity‐related erythroid alterations were found to be sex‐dependent, with increased contents of iron, zinc, and copper being exclusively detected among female subjects. Our findings suggest that a sexually dimorphic hormonal dysregulation in response to a pathological cascade involving inflammatory processes and hyperinsulinemia could be the main trigger of this female‐specific intracellular sequestration of trace elements. Therefore, the present study highlights the relevance of genotypic sex as a susceptibility factor influencing the pathogenic events behind childhood obesity, thereby opening the door to develop sex‐personalized approaches in the context of precision medicine.

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Female obesity: Association with endocrine disruption and reproductive dysfunction

Cited by 14 publications

References 251 publications

Multimodal metabolic imaging of the ovary under diet manipulation during aging process

Multimodal metabolic imaging of the ovary under diet manipulation during aging process

A cross-sectional study on factors associated with secondary amenorrhoea among the students who attended Polyclinic Universiti Malaysia Sabah with irregular menstruation

Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones

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