Female Preponderance for Lisinopril-Induced Cough in Hypertension

Os, Ingrid; Bratland, Bjørn; Dahlöf, Björn; Gisholt, Kjell; Syvertsen, Jan Otto; Tretli, Steinar

doi:10.1093/ajh/7.11.1012

Cited by 79 publications

(53 citation statements)

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“…Indeed, we did find that although women were more likely to continue treatment with other antihypertensive drugs than men, they were significantly more likely to discontinue ACE inhibitor therapy than men (49 vs. 41%), a finding consistent with that in other studies (18 -23). Although there is insufficient clinical information in the databases used for this study to explore why women had higher rates of ACE inhibitor discontinuation, reports from clinical trials and registries have consistently documented that women are at higher risk of ACE inhibitor-induced cough than men (21)(22)(23). The reasons behind this and the optimal strategy to minimize potential adverse effects with ACE inhibition in women remain active areas of research.…”

Section: Results -Frommentioning

confidence: 99%

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

McAlister

Campbell²,

Duong-Hua³

et al. 2006

Diabetes Care

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OBJECTIVE -The purpose of this study was to examine whether prescribing practices for elderly individuals with diabetes and hypertension changed over the past decade. RESEARCH DESIGN AND METHODS -We linked the Ontario Diabetes Databaseand four administrative databases in Ontario, Canada, to identify 27,822 patients Ͼ65 years of age who had diabetes and were newly treated for hypertension between 1 January 1995 and 31 December 2001. All patients were followed for 2 years after their initial antihypertensive medication prescription.RESULTS -The 27,822 patients in this study (mean age 72 years, 51% men) were treated with oral hypoglycemic agents alone (n ϭ 17,128 patients, 62%), insulin alone (n ϭ 2,346, 8%), both oral hypoglycemic agents and insulin (n ϭ 2,205, 8%), or diet alone (n ϭ 6,143, 22%). Management within the first 2 years of hypertension diagnosis consisted of antihypertensive monotherapy in 20,183 patients (73%), two antihypertensive drugs in 6,207 (22%), and three or more drugs in 1,432 (5%); the most frequently chosen antihypertensive drugs were ACE inhibitors (68%), thiazides (15%), and calcium channel blockers (9%). Between 1995 and 2001, physician prescribing practices changed: the population-adjusted rates of antihypertensive drug prescribing increased by 46% (95% CI 33-55%), the proportion of initial antihypertensive prescriptions for ACE inhibitors increased from 54 to 76% (P Ͻ 0.0001), and the use of multiple antihypertensive agents within the first 2 years of diagnosis increased from 21 to 32% (P Ͻ 0.0001).CONCLUSIONS -Antihypertensive prescribing patterns in elderly individuals with diabetes changed over the past decade in Ontario in directions consistent with the evolving evidence base. Diabetes Care 29:836 -841, 2006A lthough most patients with diabetes die of atherosclerotic disease (1), practice audits consistently highlight the suboptimal control of atherosclerotic risk in individuals with diabetes. In particular, numerous studies have demonstrated that few patients with diabetes have their blood pressure lowered to currently recommended targets (130/80 mmHg) (2-8), despite the fact that the benefits of aggressive blood pressure lowering may exceed those of aggressive glycemic control and that control of blood pressure has been identified by the Centers for Disease Control and Prevention as the most cost-effective intervention for reducing macrovascular risk in individuals with diabetes (9 -11).However, practice audits are typically small, drawn from highly select samples, frequently rely on patient self-report, are usually cross-sectional, and leave some questions unanswered. In particular, by focusing only on measured blood pressure levels, these audits have been unable to show whether the care gap in hypertensive individuals with diabetes is due to physician factors (such as underprescription of antihypertensive agents and/or failure to initiate treatment with multiple drugs to achieve blood pressure targets), patient factors (for example, noncompliance with medications or failure to...

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Section: Results -Frommentioning

confidence: 99%

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

McAlister

Campbell²,

Duong-Hua³

et al. 2006

Diabetes Care

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“…Female patients more often experience adverse effects, e.g. dry cough, than male patients when prescribed ACE inhibitors (17). Finally, a true under-prescription of recommended drugs in elderly female patients with diabetes should also be considered and the focus for further investigations.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Gender differences in risk factor control and treatment profile in diabetes: a study in 229 Swedish primary health care centres

Nilsson

Theobald

Journath

et al. 2004

Scandinavian Journal of Primary Health Care

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“…Although the cause of female predominance is unknown, most studies have attributed it to females having cough receptors that are more sensitive than are those of males. (10)(11)(12)(13)17) Other researchers have attributed it to the modulating effect that estrogen and progesterone have differs from that reported in the ECRHS study, in which obesity was associated with all three types of cough. (13) The geographical variation in the results might be due to the high prevalence of obesity in the developed world, as opposed to that seen in the developing world, from which our study population was drawn.…”

Section: Discussionmentioning

confidence: 87%

“…(7) Studies have discovered a female predisposition to cough and have shown that angiotensin-converting enzyme inhibitors induce cough more often among women than among men. (8)(9)(10) The greater female predisposition to cough has been attributed to increased cough reflex sensitivity. (11,12) Awareness of demographic and environmental factors associated with the development of cough could promote early identification, increase prevention of such factors and improve treatment of respiratory conditions.…”

Section: Introductionmentioning

confidence: 99%

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

et al. 2010

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Objective: The aim of this study was to determine the factors associated with nocturnal, productive and dry cough among young adults in Nigeria. Methods: We evaluated 498 subjects, 20-44 years of age, in Ilorin, Nigeria, using the European Community Respiratory Health Survey (ECRHS) questionnaire, administered by trained interviewers. Results: Nocturnal cough was associated with asthma (OR = 10.87; p < 0.01), nasal allergy (OR = 6.33; p < 0.01), smoking (OR = 3.10; p < 0.01), skilled manual and non-manual work (OR = 2.86 and 2.10, respectively; p < 0.01 for both) and female gender (OR = 1.33; p = 0.17). Productive cough was associated with skilled manual and non-manual work (OR = 3.82 and 3.03, respectively; p < 0.01 for both), smoking (OR = 3.10; p < 0.01), asthma (OR = 3.27; p < 0.01) and nasal allergy (OR = 5.81; p < 0.01). Dry cough was associated with asthma (OR =5.18; p < 0.01) obesity (OR =1.88; p = 0.19), smoking (OR = 1.77; p = 1.44), nasal allergy (OR = 1.45; p = 0.26) and female gender (OR =1.36; p = 0.33). Age, gender, type of residence and obesity were not significantly associated with any type of cough (p > 0.05). Conclusions: Early prevention and treatment of conditions associated with cough, as well as the modification of social factors commonly associated with cough, are needed in order to reduce respiratory morbidity. Resultados: A tosse noturna apresentou associações com asma (OR = 10,87; p < 0,01), alergia nasal (OR = 6,33; p < 0,01), tabagismo (OR = 3,10; p < 0,01), trabalho manual e trabalho não manual especializados (OR = 2,86 e 2,10, respectivamente; p < 0,01 para ambos) e gênero feminino (OR = 1,33; p = 0,17). A tosse produtiva apresentou associações com trabalho manual e trabalho não manual especializados (OR = 3,82 e 3,03, respectivamente; p < 0,01 para ambos), tabagismo (OR = 3,10; p < 0,01), asma (OR = 3,27; p < 0,01) e alergia nasal (OR = 5,81; p < 0,01). A tosse seca apresentou associações com asma (OR =5,18; p < 0,01) obesidade (OR =1,88; p = 0,19), tabagismo (OR = 1,77; p = 1,44), alergia nasal (OR = 1,45; p = 0,26) e gênero feminino (OR =1,36; p = 0,33). A idade, o gênero, o tipo de residência e a obesidade não se associaram significativamente a nenhum tipo de tosse (p > 0,05). Conclusões: A prevenção precoce e o tratamento de condições associadas à tosse, assim como a modificação de fatores sociais comumente associados à tosse, são necessários a fim de reduzir a morbidade respiratória.Descritores: Tosse; Tabagismo; Asma; Rinite; Nigéria. longitude. The minimum sample size was arrived at through the use of a Cochran formula (14) :where N is the sample size, p is the prevalence of cough in Nigeria (taken to be 50%, since the prevalence was unknown), q = (1 − p), Z is the standard normal deviation (usually set at 1.96, which corresponds to the 95% confidence interval), and d is the desired degree of accuracy (set at 0.05 to tolerate a 5% error, N = 384). The minimum sample size was determined to be 368. The study area consists of twelve electoral wards, as defined by the s...

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Female Preponderance for Lisinopril-Induced Cough in Hypertension

Cited by 79 publications

References 0 publications

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

Antihypertensive Medication Prescribing in 27,822 Elderly Canadians With Diabetes Over the Past Decade

Gender differences in risk factor control and treatment profile in diabetes: a study in 229 Swedish primary health care centres

Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria

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