Female reproductive dysfunctions and the gut microbiota

Chadchan, Sangappa B.; Singh, Vertika; Kommagani, Ramakrishna

doi:10.1530/jme-21-0238

Cited by 53 publications

(25 citation statements)

References 94 publications

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“…A recent large study by Svensson et al (2021) on stool samples reported that the abundance of 12 bacteria in the classes Bacilli, Bacteroidia, Clostridia, Coriobacteriia, and Gammaproteobacteria strongly varied between endometriosis patients (n = 66) and healthy individuals (n = 198). The discrepancy between these studies necessitates more extensive studies of how endometriosis stage, age, race, medical history, medication use, and diet affect the bacteria involved in endometriosis (Chadchan et al, 2022). An animal study reported that at 42 days after mice were intraperitoneally injected with endometrial tissue to trigger endometriosis, there was a significant elevation in the Firmicutes/Bacteroidetes ratio between the endometriotic and control mice (Yuan et al, 2018).…”

Section: Endometriosis and Endometritismentioning

confidence: 99%

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Elkafas

Wall

Al-Hendy

et al. 2022

Front. Cell. Infect. Microbiol.

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Every year, millions of women are affected by genital tract disorders, such as bacterial vaginosis (BV), endometrial cancer, polycystic ovary syndrome (PCOS), endometriosis, and uterine fibroids (UFs). These disorders pose a significant economic burden on healthcare systems and have serious implications for health and fertility outcomes. This review explores the relationships between gut, vaginal, and uterine dysbiosis and the pathogenesis of various diseases of the female genital tract. In recent years, reproductive health clinicians and scientists have focused on the microbiome to investigate its role in the pathogenesis and prevention of such diseases. Recent studies of the gut, vaginal, and uterine microbiomes have identified patterns in bacterial composition and changes across individuals’ lives associated with specific healthy and diseased states, particularly regarding the effects of the estrogen–gut microbiome axis on estrogen-driven disorders (such as endometrial cancer, endometriosis, and UFs) and disorders associated with estrogen deficiency (such as PCOS). Furthermore, this review discusses the contribution of vitamin D deficiency to gut dysbiosis and altered estrogen metabolism as well as how these changes play key roles in the pathogenesis of UFs. More research on the microbiome influences on reproductive health and fertility is vital.

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Section: Endometriosis and Endometritismentioning

confidence: 99%

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Elkafas

Wall

Al-Hendy

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Our lab has been using archived fecal specimens to identify potential association of disruption of the fecal microbiome by oral Listeria inoculation with APOs [48, 157]. The importance of deriving as much information as possible from ongoing NHP studies is amplified by the relative difficulty and cost of such studies; thus, it is imperative that we investigate potential molecular mechanisms underlying associations between microbial niches and reproductive disease as technology advances [158]. Insight into the microbial environment of the diverse niches of the FRT could contribute to a deeper understanding of how the microbiome can impact fertility, reproductive success, and well-being of the fetus, the neonate, and the individual throughout the lifespan.…”

Section: Discussionmentioning

confidence: 99%

Non-human primate models for understanding the impact of the microbiome on pregnancy and the female reproductive tract

Hugon

Golos

2023

Biology of Reproduction

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The microbiome has been demonstrated or implicated to be involved in multiple facets of human health and disease, including not only gastrointestinal health, but metabolism, immunity, and neurology. While the predominant focus of microbiome research has been on the gut, other microbial communities such as the vaginal or oral microbiome are likely involved in physiological homeostasis. Emerging studies also aim to understand the role of different microbial niches, such as the endometrial or placental microbial communities, on the physiology and pathophysiology of reproduction, including their impact on reproductive success and the etiology of adverse pregnancy outcomes (APOs). The study of the microbiome during pregnancy, specifically how changes in maternal microbial communities can lead to dysfunction and disease, can advance the understanding of reproductive health and the etiology of APOs. In this review we will discuss the current state of non-human primate (NHP) reproductive microbiome research, highlight the progress with NHP models of reproduction, and the diagnostic potential of microbial alterations in a clinical setting to promote pregnancy health. NHP reproductive biology studies have the potential to expand knowledge and understanding of female reproductive tract (FRT) microbial communities and host-microbe or microbe-microbe interactions associated with reproductive health through sequencing and analysis. Furthermore, in this review we aim to demonstrate that macaques are uniquely suited as high-fidelity models of human female reproductive pathology.

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“…To date, no study has reported a direct link between ED and endometriosis, or between gut dysbiosis and endometriosis in humans [ 6 , 7 , 38 ]. In a recent review of the literature, the intestinal microbiota is described as an endocrine organ that can influence other organs and their signaling pathways, including the female reproductive organ [ 40 ]. Even though studies conducted on animal models suggest a link between the intestinal microbiota and endometriosis, no cause and effect relationship has been formally established between gut dysbiosis and endometriosis in humans.…”

Section: Discussionmentioning

confidence: 99%

Association between Endometriosis, Irritable Bowel Syndrome and Eating Disorders: ENDONUT Pilot Study

Aupetit

Roman²,

Coëffier

et al. 2022

JCM

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Background and aim: Irritable bowel syndrome (IBS), eating disorders (ED) and endometriosis share common pathophysiological mechanisms, involving alterations of the gut–brain axis. The aim of the ENDONUT pilot study was to investigate an association between these three diseases by screening for IBS and ED in patients with endometriosis. Method: We included patients from the CIRENDO cohort (Inter-Regional North-West Cohort of women with ENDOmetriosis) with a recent documented diagnosis of endometriosis of less than 4 years, regardless of age, date of onset of symptoms, type of endometriosis (digestive or not), with or without endometriosis-related digestive surgery. Validated questionnaires were used to screen for IBS (Rome IV, Francis score), ED (SCOFF-F, EAT-26), and anxiety/depression (HAD). Anthropometric data and lifestyle habits were also collected. The primary composite endpoint was SCOFF-F and ROME-IV scores. Results: Among 100 patients meeting inclusion criteria, 54 patients completed all the questionnaires. Of these, 19 had a positive SCOFF-F score (35.2%), 26 had a positive ROME-IV score (48.1%), and 14 patients (25.9%) had both a positive SCOFF-F score and a positive ROME-IV score (p = 0.006). Patients with positive SCOFF-F and ROME-IV scores had significantly higher HAD-anxiety and depression scores (p < 0.05). Conclusion: These results suggest a significant association between IBS, ED and endometriosis. The prevalence of IBS and ED in our population is higher than in the general population. Larger studies are needed to confirm these results, to better understand this triad, and to improve the diagnostic and multidisciplinary therapeutic management of these patients.

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Female reproductive dysfunctions and the gut microbiota

Cited by 53 publications

References 94 publications

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Gut and genital tract microbiomes: Dysbiosis and link to gynecological disorders

Non-human primate models for understanding the impact of the microbiome on pregnancy and the female reproductive tract

Association between Endometriosis, Irritable Bowel Syndrome and Eating Disorders: ENDONUT Pilot Study

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