Female Reproductive Toxicology

Goldman, Jerome M.; Cooper, Andrea M.; Ralph, Lauren

doi:10.1002/9781118683484.ch22

Cited by 2 publications

(1 citation statement)

References 139 publications

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“…The kidney develops in close relationship with the male and female genital tracts. The Wolffian duct induces development of the Müllerian duct (paramesonephric duct) the anlagen of the female oviducts, uterus, cervix, and the upper portion of the vagina 20 . In males, and under the influence of testosterone, the Wolffian duct is transformed into the male excretory ducts, the epididymis and vas deferens.…”

Section: Kidney Developmentmentioning

confidence: 99%

A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy

Seely

2017

J Toxicol Pathol

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Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in response to drug administration. The kidney is an example of a major organ that has differences in these time points in comparing juveniles to adults and in contrasting humans to laboratory animal species. Toxicologic pathologists, involved in juvenile studies, need to be aware of these time points which are age-related exposure periods of sensitivity to drug toxicity. Age-related developmental anatomic and functional maturation are factors which can affect the way that a drug is absorbed, distributed, metabolized, and excreted (ADME). Changes to any component of ADME may alter drug toxicity resulting in kidney abnormalities, nephrotoxicity, or maturational disorders. Juvenile animal kidneys may either be less resistant or more resistant to known adult nephrotoxic drug effects. Furthermore, drug toxicity observed in juvenile animal kidneys may not always correspond to similar toxicities in humans. Juvenile animal nonclinical toxicology studies targeting the kidneys have to be carefully planned to attain the maximum knowledge from each study.

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Section: Kidney Developmentmentioning

confidence: 99%

A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy

Seely

2017

J Toxicol Pathol

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Elektromanyeti̇k Alanlarin Üreme Si̇stemi̇ Üzeri̇ne Etki̇leri̇

Yalçın¹,

Saygın²

2016

Mühendislik Bilimleri Ve Tasarım Dergisi

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Teknolojik gelişmeler, günlük yaşantımızın bir parçası haline gelmiştir. Bu gelişmeler yaşamımızı kolaylaştıran tüm aletlerdir (cep telefonu, bilgisayar, televizyon, elektrikli ev aletleri, uydu antenler, kablolu iletişim sistemleri vs.). Bu aletlerden yayılan elektromanyetik radyasyon (EMR) üreme sistemini de bir çok yönden etkimektedir.. Bu etkiler, erkekte infertilite, sperm sayısında azalmalar ve kadında infertilite, adet bozuklukları, düşük artması, östrojen düzeyi artışı olarak görülmektedir. EFFECTS ON REPRODUCTIVE SYSTEM OF ELECTROMAGNETIC FIELDS KeywordsAbstract Reproductive system, Electromagnetic radiation(EMR), Mobile phones.Technological development has become part of our daily lives. These developments are all tools that can improve our lives (Mobile phones, computers, televisions, electrical appliances, satellite, wired communication systems, etc.). There are negatively affect to human health electromagnetic radiation emitted from this instrument (EMR). The reproductive system is affected by this electromagneti c radiation one of the systems in our body. These effects are in male infertility, decreased to sperm count, and female infertility, the menstrual disorders, increase to miscarry, and increase to the estrogen level.

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Female Reproductive Toxicology

Cited by 2 publications

References 139 publications

A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy

A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy

Elektromanyeti̇k Alanlarin Üreme Si̇stemi̇ Üzeri̇ne Etki̇leri̇

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