Female sex is independently associated with reduced inpatient mortality after endovascular repair of blunt thoracic aortic injury

Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation

“…[20][21][22] Regardless of mechanism, this female-specific hypercoagulability persists after injury 9,10,23 and confers decreased morbidity in the form of less blood transfusions, traumatic hemorrhage progression, intraoperative blood loss, 9,24-28 and a survival benefit. 9,29 In a secondary analysis of the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial, McCrum et al found that after anatomic hemostasis, females received lower volumes of all blood products, with a 38% reduction in plasma, 49% reduction in platelets, and 49% reduction in red blood cell volumes. 30 Males ultimately receive relatively more transfusions, 31 which translates into higher rates of transfusionrelated complications, such as ventilator-associated pneumonia, organ failure, acute respiratory distress syndrome, and longer intensive care unit and hospital length of stay.…”

“…Regardless of mechanism, this female‐specific hypercoagulability persists after injury 9,10,23 and confers decreased morbidity in the form of less blood transfusions, traumatic hemorrhage progression, intraoperative blood loss, 9,24–28 and a survival benefit 9,29 . In a secondary analysis of the Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial, McCrum et al found that after anatomic hemostasis, females received lower volumes of all blood products, with a 38% reduction in plasma, 49% reduction in platelets, and 49% reduction in red blood cell volumes 30 .…”