This study sought to synthesise evidence on the sources of sexual knowledge and information and relationship with sexual attitudes of cis men. From a review of existing literature, five categories were obtained from 11 studies and grouped into three syntheses: (1) sources of sexual knowledge and information, (2) sexual attitudes and (3) the relationship between sources of sexual knowledge and information and sexual attitudes. Sex research relation to sexual knowledge and attitudes of cis men is scant across the globe. Men desire reliable sexual information despite peers and online media being more readily available with consequences for sexual attitudes that impact on sexuality of men. We posit that research, sex education, sexological practice and policy intervention are necessary to avail knowledge that provides reliable sexual knowledge and information to men for safe sexual decision making.