Female Sexual Dysfunction in Presymptomatic Mutation Carriers and Patients with Huntington’s Disease

Kolenc, Matej; Kobal, Jan; Podnar, Simon

doi:10.3233/jhd-160224

Cited by 10 publications

(20 citation statements)

References 32 publications

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“…Of the remaining 162, only nine fulfilled our eligibility criteria. Almost all of the included studies identified several sexual dysfunctions related to HD, with the most prevalent being sexual desire disorder [7,10,11,12,13] and hyposexuality rather than hypersexuality.…”

Section: Resultsmentioning

confidence: 99%

“…The term 'female orgasmic disorder' refers to a marked delay, infrequency or absence of orgasm or orgasmic sensations that are markedly reduced in intensity [6]. Women with HD have reported more or the same level of problems regarding orgasm than control groups: 42% vs 9% [7], 53% vs 51% [14], and 78% vs 49% [12]. Unlike the male HD population, this problem does not correlate with age at disease onset [7].…”

Section: Orgasmic Dysfunctionsmentioning

confidence: 99%

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Sexual dysfunction in Huntington’s Disease — a systematic review

Szymuś

Bystrzyński

Kwaśniak-Butowska

et al. 2020

Neurol Neurochir Pol.

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Introduction. Huntington's Disease (HD) is a neurodegenerative disorder of which the main symptoms are motor, cognitive and behavioural problems sometimes including sexual dysfunction. Aim.To review the current knowledge on sexual dysfunction in HD.Methods. Databases of Pubmed and Scopus were searched. Only original studies performed after 1994 were included (from 1994 a genetic test = proven diagnosis).Results. 162 publications were found, but only nine met our established criteria. The majority of patients with HD suffer from sexual disorders. The most common are: hypoactive sexual disorder (53-83% of patients), hyperactive sexual disorder (6-30%), erectile (48-74%) and ejaculatory dysfunctions (30-65%), lubrication problems (53-83%), and orgasmic dysfunction (35-78%).Discussion. Results may be biased for several reasons e.g.: social taboos regarding sex lives, medications that affect sexual function, impaired self-awareness of patients, small study samples, a lack of standardised questionnaires, and a focus only on the presence of sexual problems without describing them.Conclusions. Sexual disorders in HD are common. This is a problem that is probably underestimated, both by patients/caregivers and physicians, who should focus more on these symptoms in order to improve patient quality of life.

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Section: Resultsmentioning

confidence: 99%

Section: Orgasmic Dysfunctionsmentioning

confidence: 99%

Sexual dysfunction in Huntington’s Disease — a systematic review

Szymuś

Bystrzyński

Kwaśniak-Butowska

et al. 2020

Neurol Neurochir Pol.

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“…The clinical features of HD are commonly described as a triad of motor, cognitive, and psychological symptoms, which are attributed to neuronal loss in the striatum and other areas of the brain. However, sparse attention has been paid to the association of HD with development of pelvic organ dysfunction, encompassing bladder, bowel, and sexual organs or the presence of concomitant symptomatology [ 2 , 3 , 4 , 5 , 6 , 7 ]. Current texts of HD rarely mention the presence of bladder and bowel dysfunction in HD, and the reporting of sexual function is presented predominantly in the context of disordered psychiatric manifestations [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

High Frequency of Concomitant Bladder, Bowel, and Sexual Symptoms in Huntington’s Disease: A Self-Reported Questionnaire Study

Vicars

Liu

Holt

et al. 2021

JPM

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Huntington’s disease (HD) can be associated with pathologic involvement beyond the striatum including the autonomic nervous system. Bladder, bowel, and sexual dysfunction have been reported independently in HD, but little is known about their concomitant occurrence. To document this concomitant phenomena, forty-eight subjects (54% male, ages 28–74 years, CAG repeat 38–61) with manifest/symptomatic HD completed detailed questionnaires regarding bladder, bowel, and sexual function. In total, 45 subjects (93.8%) reported symptoms in at least one organ system (bladder, bowel, or sexual), 13 (27.1%) reported symptoms in two systems, and 19 (39.6%) reported concomitant symptoms in all three systems. Urinary problems were most frequent in 42 subjects (87.5%) followed by lower bowel (60.4%) and sexual dysfunction (56.2%). Participants reporting concomitant symptoms were more likely to have longer duration of disease and lower Total Functional Capacity (TFC) scores. This study documents the high frequency of bladder, bowel, and sexual dysfunction in HD and the common occurrence of concomitance of these pelvic organ problems.

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“…[3][4][5] Alongside the characteristic triad of cognitive, behavioral, and movement deficits, 6 a range of symptoms suggestive of autonomic nervous system (ANS) dysfunction have been shown to exist in patients with HD. For example, excessive sweating, micturition difficulties, orthostatic intolerance, sexual dysfunction, gastrointestinal problems, and tachycardia have been reported in patients across disease stages, including premanifest gene carriers, [7][8][9][10] suggesting that autonomic symptoms contribute to the clinical phenotype of HD and disease burden.…”

mentioning

confidence: 99%