Background: Injurious falls in hospital patients are threat to patient safety which can result in a financial burden on the patient’s family and health care services. Both patient specific and environmental and organisational factors are associated with injurious hospital falls. It is important to continuously analyse the factors associated with the severity of falls which can inform the implementation of any fall preventive strategies. This study aims to identify risk factors associated with the severity of falls in hospitalised adult patients in Western Australia.Methods: This study involved a retrospective analysis of hospital inpatient falls records extracted from the hospital’s Clinical Incident Database. Falls clinical incidents were reviewed and analysed from May 2014 to April 2019.Results: There were 3705 complete reported cases of falls with the average age of the patients was 68.5±17.0 years, with 40.2% identified as female. Gender, activity at time of fall and height of fall were associated with the level of severity of the fall. The risk of falling at a higher level of severity increased by approximately 20% (65-74 years), 29% (75-84 years) and 39% (>84 years) respectively compared with patients age <50 years. Females were 15.1% more likely to fall at higher severity condition compared to males (AOR = 1.151, 95% CI: 1.063, 1.247, p < 0.001). Toileting and showering activities were 14.5% more likely to cause falling in higher level of severity (AOR = 1.145, 95% CI: 1.022, 1.284, p = 0.020) compared with attempting to sit or stand. A fall in a communal area was approximately 26% more likely to resulted in higher level of severity (AOR = 1.257, 95% CI: 1.003, 1.576, p = 0.047).Conclusions: Identification of underlying risk factors associated with the severity of falls provides information which can inform the implementation of fall prevention strategies that mitigate the risk of injurious falls.