The authors examined career salience, work satisfaction, and depression among 189 clergywomen from all geographic regions of the United States. Participants demonstrated, on average, a moderate level of commitment to their careers and exhibited a high degree of work satisfaction, yet the majority also showed many symptoms of non-clinical depression. A regression model controlling for demographics and work history and conditions revealed that work satisfaction had a significant negative effect on depression, suggesting that higher job satisfaction results in less depression. The effect of career commitment on depression approached significance, suggesting greater levels of commitment resulted in higher levels of depression.