2007
DOI: 10.1016/j.aquatox.2007.06.011
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Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis

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Cited by 23 publications
(12 citation statements)
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“…Qin et al . () demonstrated that polychlorinated biphenyl exposure in X. laevis inhibited Müllerian duct regression in juvenile males, likely resulting from observed decreases in serum testosterone levels. Taken together, all of these studies appear to support that estrogen is necessary, but not sufficient to cause oviduct maturation in Xenopus, and androgen‐mediated Müllerian duct regression appears to trump endogenous estrogenic influence on the oviduct.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation
“…Qin et al . () demonstrated that polychlorinated biphenyl exposure in X. laevis inhibited Müllerian duct regression in juvenile males, likely resulting from observed decreases in serum testosterone levels. Taken together, all of these studies appear to support that estrogen is necessary, but not sufficient to cause oviduct maturation in Xenopus, and androgen‐mediated Müllerian duct regression appears to trump endogenous estrogenic influence on the oviduct.…”
Section: Discussionmentioning
confidence: 97%
“…Conversely, when X. tropicalis were exposed to the anti-estrogen fadrozole (aromatase inhibitor) at concentrations of 16 and 64 μg l -1 , all females in those treatments were sex reversed into phenotypic males that did not have oviducts (Olmstead et al, 2009b). Qin et al (2007) demonstrated that polychlorinated biphenyl exposure in X. laevis inhibited Müllerian duct regression in juvenile males, likely resulting from observed decreases in serum testosterone levels. Taken together, all of these studies appear to support that estrogen is necessary, but not sufficient to cause oviduct maturation in Xenopus, and androgen-mediated Müllerian duct regression appears to trump endogenous estrogenic influence on the oviduct.…”
Section: Discussionmentioning
confidence: 99%
“…However, the many demonstrations that EDCs alter gonadal differentiation and influence genes coding for steroidogenic factor-1 (SF-1) and other steroidogenic enzymes make this very likely. Strong evidence for such effects might be found in the Xenopus, in which both atrazine and PCB exposure inhibited laryngeal (both cartilage and muscle) development (Hayes et al, 2002;Qin et al, 2007), a sexually dimorphic structure important in the male calling behavior (Kelley and Brenowitz, 2002). Treating female red-spotted newts (Notophthalmus viiridescens) with the insecticide endosulfan disrupted mate choice and lowered mating success (Park et al, 2001;Park and Propper, 2002).…”
Section: Birds Reptiles and Amphibiansmentioning
confidence: 97%
“…Oviducts are female secondary sex characteristics that function in oocyte maturation during reproduction (Wake and Dickie, 1998). The development of oviducts in males following exposure to PCBs (Qin et al, 2007) and octylphenol (Porter et al, 2009) has been reported. Oviduct development appears to be regulated by estrogens as development correlates with blood E2 levels in X. laevis (Tobias et al, 1998) and X. tropicalis (Olmstead et al, 2009d).…”
Section: Basic Biology and Test Overviewmentioning
confidence: 99%