FEMMINA real-time, radio-frequency echo-signal equipment for testing novel investigation methods

Masotti, L.; Biagi, E.; Scabia, M.; Acquafresca, A.; Facchini, R.; Ricci, Andrea; Bini, Donato

doi:10.1109/tuffc.2006.111

Cited by 28 publications

(11 citation statements)

References 20 publications

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“…Thanks to advances in spectral analyses based on wavelet decomposition of the raw radio frequency (RF) signals, tailored color maps can be developed and superimposed on conventional echographic images, in order to automatically highlight nano-sized differences in tissue [25], [26]. Exploring the applicability of this approach to NPCA-enhanced imaging we showed the possibility of automatically detecting SiNSs on echographic images with sensitivities of up to about 77% [24].…”

Section: B Automatic Segmentation Of Tissue-targeted Sinssmentioning

confidence: 99%

Effectiveness of Functionalized Nanosystems for Multimodal Molecular Sensing and Imaging in Medicine

et al. 2013

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Successful employment of multimodal molecular imaging for cancer targeting entails the development of safe nanoparticle contrast agents (NPCAs), detects at least by two nonionizing imaging techniques. This paper presents a quantitative assessment of the effectiveness of both pure silica nanospheres (SiNSs) and composite silica/superparamagnetic NPCAs as scatterers for low-frequency diagnostic ultrasound (US) (3 MHz) in very low range of concentrations (1.5-5 mg/mL). Iron oxide (IO) and FePt-IO nanocrystals are employed for SiNS magnetic coating. Different samples of NPCA-containing agarose gel are US imaged through a commercially available system and acquired data are processed through a dedicated prototypal platform to extract image backscatter information and perform evaluation of the image gray level. The pure silica NPCAs confirms recent reports for higher concentrations at higher frequencies. The FePt-IO-coated NPCAs show similar behavior, although with lower values of image backscatter, with a marked effectiveness peak for 330-nm SiNSs, particularly useful for tumor targeting purposes. Finally, the IO-coated SiNSs presented a marked lowering of US enhancement potential and a peak efficiency for a particle diameter of 660 nm. The extent of US backscatter reduction is found to be a function of the number of magnetic nanoparticles per mL of NPCA-containing gel and decreased with increasing NPCA concentrations. These results broadened our knowledge of dual-mode molecular imaging of deep tumors, employing US, and magnetic resonance techniques for the accurate, safe and early detection of cancer cells located in internal organs.Index Terms-Biomedical cancer detection, biomedical image processing, medical diagnostic imaging molecular imaging, nanoparticles.

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Section: B Automatic Segmentation Of Tissue-targeted Sinssmentioning

confidence: 99%

Effectiveness of Functionalized Nanosystems for Multimodal Molecular Sensing and Imaging in Medicine

et al. 2013

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“…A software for wavelet decomposition and spectral analysis (RULES, ELEN SpA, Florence, Italy) was applied to raw ultrasound signals acquired through FEMMINA, 23 and employed to develop a tailored color map then superimposed to B-mode images.…”

Section: Automatic Nanoparticle Detection Through Rf Signal Analysismentioning

confidence: 99%

Optimal Enhancement Configuration of Silica Nanoparticles for Ultrasound Imaging and Automatic Detection at Conventional Diagnostic Frequencies

Casciaro

Conversano²,

Ragusa³

et al. 2010

Investigative Radiology

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Silica nanoparticles at a diameter of about 330 nm are very promising contrast agents for ultrasound imaging and specific tumor targeting at conventional diagnostic frequencies, being in particular automatically detectable with high sensitivity already at low doses. Future studies will be carried out to assess the acoustic behavior of nanoparticles with different geometries/sizes and to improve sensitivity of the automatic detection algorithm.

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“…3, a typical setup used for opto-acoustic ultrasound generation is shown. A FEMMINA (Fast Echographic Multi parameters Multi Image Novel Apparatus) system [8] is used both to acquire data and to manage hardware control and synchronization. FEMMINA is a hardware/software platform devoted to acquire, analyze and visualize in real time data produced at the same time from different sources or algorithms.…”

Section: Opto-acoustic Sourcementioning

confidence: 99%

Fiber optic broadband ultrasonic probe

et al. 2008

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An ultrasonic probe was developed by using, in conjunction, opto-acoustic and acousto-optic devices based on fiber optic technology. The intrinsic high frequency and wide bandwidth associated both to the opto-acoustic source and to the interferometric acousto-optic element could open a way towards a "virtual biopsy" of the biological tissue by means of appropriate signal processing techniques to investigate frequency-selective responses in tissue. Extreme miniaturization, which can be obtained by fiber optic technology, permits the positioning of the probe in the close proximity of the focal lesion, avoiding the reduction of the penetration depth imposed by the strong attenuation at high frequency.

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FEMMINA real-time, radio-frequency echo-signal equipment for testing novel investigation methods

Cited by 28 publications

References 20 publications

Effectiveness of Functionalized Nanosystems for Multimodal Molecular Sensing and Imaging in Medicine

Effectiveness of Functionalized Nanosystems for Multimodal Molecular Sensing and Imaging in Medicine

Optimal Enhancement Configuration of Silica Nanoparticles for Ultrasound Imaging and Automatic Detection at Conventional Diagnostic Frequencies

Fiber optic broadband ultrasonic probe

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